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All Outputs (133)

Quantification of cerebral perfusion and cerebrovascular reserve using Turbo‐QUASAR arterial spin labeling MRI (2019)
Journal Article
Zhao, M. Y., Václavů, L., Petersen, E. T., Biemond, B. J., Sokolska, M. J., Suzuki, Y., Thomas, D. L., Nederveen, A. J., & Chappell, M. A. (2020). Quantification of cerebral perfusion and cerebrovascular reserve using Turbo‐QUASAR arterial spin labeling MRI. Magnetic Resonance in Medicine, 83(2), 731-748. https://doi.org/10.1002/mrm.27956

Purpose
To compare cerebral blood flow (CBF) and cerebrovascular reserve (CVR) quantification from Turbo‐QUASAR (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) arterial spin labeling (ASL) and single post... Read More about Quantification of cerebral perfusion and cerebrovascular reserve using Turbo‐QUASAR arterial spin labeling MRI.

Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization (2019)
Journal Article
Brainin, M., Feigin, V., Bath, P. M., Collantes, E., Martins, S., Pandian, J., Sacco, R., & Teuschl, Y. (2019). Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization. International Journal of Stroke, 14(8), 818-825. https://doi.org/10.1177/1747493019873706

The increasing burden of stroke and dementia emphasizes the need for new, well-tolerated and cost-effective primary prevention strategies that can reduce the risks of stroke and dementia worldwide, and specifically in low- and middle-income countries... Read More about Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization.

Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane (2019)
Journal Article
Marsit, N. M., Sidney, L. E., Britchford, E. R., McIntosh, O. D., Allen, C. L., Ashraf, W., Bayston, R., & Hopkinson, A. (2019). Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane. Scientific Reports, 9(1), Article 12854. https://doi.org/10.1038/s41598-019-49314-7

© 2019, The Author(s). Amniotic membrane (AM) is used to treat a range of ophthalmic indications but must be presented in a non-contaminated state. AM from elective caesarean sections contains natural microbial contamination, requiring removal during... Read More about Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane.

Consensus Practice Parameter: Audiological Assessment and Management of Unilateral Hearing Loss in Children (2019)
Journal Article
Bagatto, M., DesGeorge, J., Kitterick, P., Laurnagaray, D., Roush, P., Sladen, D., & Tharpe, A. (2019). Consensus Practice Parameter: Audiological Assessment and Management of Unilateral Hearing Loss in Children. International Journal of Audiology, https://doi.org/10.1080/14992027.2019.1654620

Objective: Provide recommendations to audiologists for the management of children with unilateral hearing loss (UHL) and for needed research that can lend further insight on important unanswered questions.

Design: An international panel of experts... Read More about Consensus Practice Parameter: Audiological Assessment and Management of Unilateral Hearing Loss in Children.

In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles (2019)
Journal Article
Al-Aqaba, M. A., Anis, F. S., Mohammed, I., Yapa, A. D. S., Amoaku, W. M., & Dua, H. S. S. (2019). In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles. British Journal of Ophthalmology, 1-5. https://doi.org/10.1136/bjophthalmol-2018-313199

Aims To describe the in vivo confocal microscopy (IVCM) features of human limbal nerve corpuscles (LNCs) and correlate these with the histological features.

Methods We examined 40 eyes of 29 healthy living subjects (17 female, 12 male; mean age=47... Read More about In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles.

Robust estimation of quantitative perfusion from multi‐phase pseudo‐continuous arterial spin labeling (2019)
Journal Article
Msayib, Y., Craig, M., Simard, M. A., Larkin, J. R., Shin, D. D., Liu, T. T., Sibson, N. R., Okell, T. W., & Chappell, M. A. (2020). Robust estimation of quantitative perfusion from multi‐phase pseudo‐continuous arterial spin labeling. Magnetic Resonance in Medicine, 83(3), 815-829. https://doi.org/10.1002/mrm.27965

Purpose
Multi‐phase PCASL has been proposed as a means to achieve accurate perfusion quantification that is robust to imperfect shim in the labeling plane. However, there exists a bias in the estimation process that is a function of noise in the dat... Read More about Robust estimation of quantitative perfusion from multi‐phase pseudo‐continuous arterial spin labeling.

Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis (2019)
Journal Article
Sinnecker, T., Clarke, M. A., Meier, D., Enzinger, C., Calabrese, M., De Stefano, N., Pitiot, A., Giorgio, A., Schoonheim, M., Paul, F., Pawlak, M. A., Schmidt, R., Kappos, L., Montalban, X., Rovira, À., Evangelou, N., Wuerfel, J., & MAGNIMS Study Group. (2019). Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis. JAMA Neurology, 76(12), 1446-1456. https://doi.org/10.1001/jamaneurol.2019.2478

© 2019 American Medical Association. All rights reserved. Importance: The central vein sign has been proposed as a specific imaging biomarker for distinguishing between multiple sclerosis (MS) and not MS, mainly based on findings from ultrahigh-field... Read More about Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis.

The ESCAPS study: a feasibility randomized controlled trial of early electrical stimulation to the wrist extensors and flexors to prevent post-stroke complications of pain and contractures in the paretic arm (2019)
Journal Article
Fletcher-Smith, J. C., Pandyan, A. D., Fletcher-Smith, J. C., Walker, D. M., Allatt, K., Sprigg, N., James, M., Ratib, S., Boadu, J., Richardson, C., & Pandyan, A. D. (2019). The ESCAPS study: a feasibility randomized controlled trial of early electrical stimulation to the wrist extensors and flexors to prevent post-stroke complications of pain and contractures in the paretic arm. Clinical Rehabilitation, 33(12), 1919-1930. https://doi.org/10.1177/0269215519868834

© The Author(s) 2019. Objective: To establish feasibility of initiating electrical stimulation treatment of wrist extensors and flexors in patients early after stroke to prevent muscle contractures and pain. Design: Feasibility randomized controlled... Read More about The ESCAPS study: a feasibility randomized controlled trial of early electrical stimulation to the wrist extensors and flexors to prevent post-stroke complications of pain and contractures in the paretic arm.

Longitudinal associations between hearing loss and general cognitive ability: the Lothian Birth Cohort 1936 (2019)
Journal Article
Okely, J. A., Akeroyd, M. A., Allerhand, M., Starr, J. M., & Deary, I. J. (2019). Longitudinal associations between hearing loss and general cognitive ability: the Lothian Birth Cohort 1936. Psychology and Aging, 34(6), 766-779. https://doi.org/10.1037/pag0000385

Hearing impairment is associated with poorer cognitive function in later life. We tested for the potential contribution of childhood cognitive ability to this relationship. Childhood cognitive ability is strongly related to cognitive function in olde... Read More about Longitudinal associations between hearing loss and general cognitive ability: the Lothian Birth Cohort 1936.

Why Is There No Cure for Tinnitus? (2019)
Journal Article
McFerran, D. J., Stockdale, D., Holme, R., Large, C. H., & Baguley, D. M. (2019). Why Is There No Cure for Tinnitus?. Frontiers in Neuroscience, 13, Article 802. https://doi.org/10.3389/fnins.2019.00802

Tinnitus is unusual for such a common symptom in that there are few treatment options and those that are available are aimed at reducing the impact rather than specifically addressing the tinnitus percept. In particular, there is no drug recommended... Read More about Why Is There No Cure for Tinnitus?.

High oxygen fraction during airway opening is key to effective airway rescue in obese subjects (2019)
Presentation / Conference Contribution
Laviola, M., Christian, N., Alahmadi, H., Das, A., Bates, D. G., & Hardman, J. G. (2019, July). High oxygen fraction during airway opening is key to effective airway rescue in obese subjects. Presented at 2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Berlin, Germany

Apnea is common after induction of anesthesia and may produce dangerous hypoxemia, particularly in obese subjects. Optimal management of airway emergencies in obese, apneic subjects is complex and controversial, and clinical studies of rescue strateg... Read More about High oxygen fraction during airway opening is key to effective airway rescue in obese subjects.

Cochrane corner: Sound therapy (using amplification devices and/or sound generators) for tinnitus (2019)
Journal Article
Brennan-Jones, C. G., Thomas, A., Hoare, D. J., & Sereda, M. (2019). Cochrane corner: Sound therapy (using amplification devices and/or sound generators) for tinnitus. International Journal of Audiology, 59(3), 1-5. https://doi.org/10.1080/14992027.2019.1643503

This Cochrane Corner features “Sound therapy (using amplification devices or sound generators) for tinnitus” published in 2018. Sereda et al. identified eight clinical trials including 590 participants receiving sound therapy for tinnitus. None of th... Read More about Cochrane corner: Sound therapy (using amplification devices and/or sound generators) for tinnitus.

Internet-Based Interventions for Adults With Hearing Loss, Tinnitus, and Vestibular Disorders: A Systematic Review and Meta-Analysis (2019)
Journal Article
Beukes, E. W., Manchaiah, V., Allen, P. M., Baguley, D. M., & Andersson, G. (2019). Internet-Based Interventions for Adults With Hearing Loss, Tinnitus, and Vestibular Disorders: A Systematic Review and Meta-Analysis. Trends in Hearing, 23, 1-22. https://doi.org/10.1177/2331216519851749

Internet-based interventions have been developed to improve access to audiovestibular health care. This review aimed to identify outcomes of Internet interventions for adults with hearing loss, tinnitus, and vestibular disorders. Electronic databases... Read More about Internet-Based Interventions for Adults With Hearing Loss, Tinnitus, and Vestibular Disorders: A Systematic Review and Meta-Analysis.

Evaluating time-reversed speech and signal-correlated noise as auditory baselines for isolating speech-specific processing using fNIRS (2019)
Journal Article
Mushtaq, F., Wiggins, I. M., Kitterick, P. T., Anderson, C. A., & Hartley, D. E. H. (2019). Evaluating time-reversed speech and signal-correlated noise as auditory baselines for isolating speech-specific processing using fNIRS. PLoS ONE, 14(7), Article e0219927. https://doi.org/10.1371/journal.pone.0219927

Evidence using well-established imaging techniques, such as functional magnetic resonance imaging and electrocorticography, suggest that speech-specific cortical responses can be functionally localised by contrasting speech responses with an auditory... Read More about Evaluating time-reversed speech and signal-correlated noise as auditory baselines for isolating speech-specific processing using fNIRS.

Comorbidity in multiple sclerosis: its temporal relationships with disease onset and dose effect on mortality (2019)
Journal Article
Chou, I. J., Kuo, C. F., Tanasescu, R., Tench, C. R., Tiley, C. G., Constantinescu, C. S., & Whitehouse, W. P. (2020). Comorbidity in multiple sclerosis: its temporal relationships with disease onset and dose effect on mortality. European Journal of Neurology, 27(1), 105-112. https://doi.org/10.1111/ene.14040

© 2019 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. Background and purpose: We aimed to determine the burden of comorbidities at the time of diagnosis of multiple sclerosi... Read More about Comorbidity in multiple sclerosis: its temporal relationships with disease onset and dose effect on mortality.

Joint modelling of diffusion MRI and microscopy (2019)
Journal Article
Howard, A. F., Mollink, J., Kleinnijenhuis, M., Pallebage-Gamarallage, M., Bastiani, M., Cottaar, M., Miller, K. L., & Jbabdi, S. (2019). Joint modelling of diffusion MRI and microscopy. NeuroImage, 201, Article 116014. https://doi.org/10.1016/j.neuroimage.2019.116014

The combination of diffusion MRI (dMRI) with microscopy provides unique opportunities to study microstructural features of tissue, particularly when acquired in the same sample. Microscopy is frequently used to validate dMRI microstructure models, ad... Read More about Joint modelling of diffusion MRI and microscopy.

Congenital monocular elevation deficiency associated with a novel TUBB3 gene variant (2019)
Journal Article
Thomas, M. G., Maconachie, G. D., Constantinescu, C. S., Chan, W.-M., Barry, B., Hisaund, M., Sheth, V., Kuht, H. J., Dineen, R. A., Harieaswar, S., Engle, E. C., Gottlob, I., & Thomas, G. (2020). Congenital monocular elevation deficiency associated with a novel TUBB3 gene variant. British Journal of Ophthalmology, 104(4), 547-550. https://doi.org/10.1136/bjophthalmol-2019-314293

Background The genetic basis of monocular elevation deficiency (MED) is unclear. It has previously been considered to arise due to a supranuclear abnormality.

Methods Two brothers with MED were referred to Leicester Royal Infirmary, UK from the lo... Read More about Congenital monocular elevation deficiency associated with a novel TUBB3 gene variant.

Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain (2019)
Journal Article
Knight, M. J., Damion, R. A., McGarry, B. L., Bosnell, R., Jokivarsi, K. T., Gröhn, O. H., Jezzard, P., Harston, G. W., Carone, D., Kennedy, J., El-Tawil, S., Elliot, J., Muir, K. W., Clatworthy, P., & Kauppinen, R. A. (2019). Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain. Biomedical Spectroscopy and Imaging, 8(1-2), 11-28. https://doi.org/10.3233/bsi-190185

BACKGROUND AND OBJECTIVE: In hyperacute ischaemic stroke, T2 of cerebral water increases with time. Quantifying this change may be informative of the extent of tissue damage and onset time. Our objective was to develop a user-unbiased method to measu... Read More about Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain.