All Outputs (133)

Corneal nerves in health and disease (2019)
Journal Article
Al Aqaba, M. A., Dhillon, V. K., Mohammed, I., Said, D. G., & Dua, H. S. (2019). Corneal nerves in health and disease. Progress in Retinal and Eye Research, 73, Article 100762. https://doi.org/10.1016/j.preteyeres.2019.05.003

The cornea is the most sensitive structure in the human body. Corneal nerves adapt to maintain transparency and contribute to corneal health by mediating tear secretion and protective reflexes and provide trophic support to epithelial and stromal cel... Read More about Corneal nerves in health and disease.

Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system (2019)
Journal Article
Martín-Bastida, A., Lao-Kaim, N. P., Roussakis, A. A., Searle, G. E., Xing, Y., Gunn, R. N., …Piccini, P. (2019). Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system. Brain, 142(7), 2023–2036. https://doi.org/10.1093/brain/awz120

© 2019 The Author(s). All rights reserved. Parkinson's disease is characterized by the progressive loss of pigmented dopaminergic neurons in the substantia nigra and associated striatal deafferentation. Neuromelanin content is thought to reflect the... Read More about Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system.

Determining the sample size for future trials of hearing instruments for unilaterally deaf adults: an application of network meta-analysis (2019)
Journal Article
Gaunt, A. C., & Kitterick, P. T. (2019). Determining the sample size for future trials of hearing instruments for unilaterally deaf adults: an application of network meta-analysis. Otology and Neurotology, 40(4), e342–e348. https://doi.org/10.1097/MAO.0000000000002186

Objective: Previous trials have compared the efficacy of hearing instruments to no intervention in adults with single- sided deafness (SSD) or the relative efficacy of different instruments. Network meta-analysis (NMA) was used to refine estimates of... Read More about Determining the sample size for future trials of hearing instruments for unilaterally deaf adults: an application of network meta-analysis.

How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin (2019)
Journal Article
Hall, D. A., Kitterick, P. T., Heffernan, E., Fackrell, K., Lucas, L., & Ferguson, M. (2019). How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin. Otology and Neurotology, 40(4), e474-e481. https://doi.org/10.1097/MAO.0000000000001937

This short review article gives an introduction to some of the fundamental concepts and challenges facing measurement in hearing healthcare practice and research. The impact of hearing loss almost always extends beyond the sensory impairment itself,... Read More about How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin.

Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients (2019)
Journal Article
Damion, R. A., Knight, M. J., McGarry, B. L., Bosnell, R., Jezzard, P., Harston, G. W., …Kauppinen, R. A. (2019). Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients. Physics in Medicine and Biology, 64(9), Article 095016. https://doi.org/10.1088/1361-6560/ab1442

The apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T2 relaxation time changes in ischaemic brain such that T2 in ADC lesion... Read More about Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients.

Hearing impairment and daily-life fatigue: a qualitative study (2019)
Journal Article
Holman, J. A., Drummond, A., Hughes, S. E., & Naylor, G. (2019). Hearing impairment and daily-life fatigue: a qualitative study. International Journal of Audiology, 58(7), 408-416. https://doi.org/10.1080/14992027.2019.1597284

Objective: Hearing impairment is linked to increased fatigue, yet little is known about the real-world impact of this fatigue. This qualitative study investigated the experience of daily-life fatigue in people with a hearing impairment.
Design: Ind... Read More about Hearing impairment and daily-life fatigue: a qualitative study.

Content validity and readability of patient-reported questionnaire instruments of hearing disability (2019)
Journal Article
Manchaiah, V., Granberg, S., Grover, V., Saunders, G., & Hall, D. (2019). Content validity and readability of patient-reported questionnaire instruments of hearing disability. International Journal of Audiology, 58(9), 565-575. https://doi.org/10.1080/14992027.2019.1602738

Objective: The current study evaluates the content validity (i.e., domains assessed) and readability levels of patient-reported questionnaire instruments using internationally recognized
procedures and tools.

Design: A review of the literature to... Read More about Content validity and readability of patient-reported questionnaire instruments of hearing disability.

Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: the LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial (2019)
Journal Article
Blair, G. W., Appleton, J. P., Flaherty, K., Doubal, F., Sprigg, N., Dooley, R., …Wardlaw, J. M. (2019). Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: the LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial. eClinicalMedicine, 11, 34-43. https://doi.org/10.1016/j.eclinm.2019.04.001

Background
Lacunar stroke, a frequent clinical manifestation of small vessel disease (SVD), differs pathologically from other ischaemic stroke subtypes and has no specific long-term secondary prevention. Licenced drugs, isosorbide mononitrate (ISMN)... Read More about Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: the LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial.

Factors related to insomnia in adult patients with tinnitus and/or hyperacusis: an exploratory analysis (2019)
Journal Article
Aazh, H., Baguley, D. M., & Moore, B. C. (2019). Factors related to insomnia in adult patients with tinnitus and/or hyperacusis: an exploratory analysis. Journal of the American Academy of Audiology, 30(9), 802-809. https://doi.org/10.3766/jaaa.18020

Background: People with tinnitus and/or hyperacusis often experience insomnia. However, it is unclear what factors are most strongly associated with insomnia. Purpose: To explore factors related to insomnia in patients with tinnitus and/or hyperacusi... Read More about Factors related to insomnia in adult patients with tinnitus and/or hyperacusis: an exploratory analysis.

Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial (2019)
Journal Article
van der Worp, H. B., Macleod, M. R., Bath, P. M., Bathula, R., Christensen, H., Colam, B., …the EuroHYP-1 investigators. (2019). Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial. European Stroke Journal, 4(3), 254-262. https://doi.org/10.1177/2396987319844690

© European Stroke Organisation 2019. Introduction: We assessed whether modest systemic cooling started within 6 hours of symptom onset improves functional outcome at three months in awake patients with acute ischaemic stroke. Patients and methods: In... Read More about Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial.

Endothelial progenitor cells: Potential novel therapeutics for ischaemic stroke (2019)
Journal Article
Bayraktutan, U. (2019). Endothelial progenitor cells: Potential novel therapeutics for ischaemic stroke. Pharmacological Research, 144, 181-191. https://doi.org/10.1016/j.phrs.2019.04.017

Stroke is classified into two main groups depending on its aetiology; ischaemic stroke and haemorrhagic stroke which successively develop from the occlusion or rupture of an artery leading to the brain. Despite being the leading cause of human cerebr... Read More about Endothelial progenitor cells: Potential novel therapeutics for ischaemic stroke.

A scoping review to catalogue tinnitus problems in children (2019)
Journal Article
Smith, H., Fackrell, K., Kennedy, V., Barry, J., Partridge, L., & Hoare, D. J. (2019). A scoping review to catalogue tinnitus problems in children. International Journal of Pediatric Otorhinolaryngology, 122, 141-151. https://doi.org/10.1016/j.ijporl.2019.04.006

© 2019 The Authors Background: The reported prevalence of tinnitus in children is similar to that in adults. However, unlike adults, there is relatively little understanding of the tinnitus-related problems children experience. Knowledge of the probl... Read More about A scoping review to catalogue tinnitus problems in children.

The Cost-Effectiveness of Bimodal Stimulation Compared to Unilateral and Bilateral Cochlear Implant Use in Adults with Bilateral Severe to Profound Deafness (2019)
Journal Article
Theriou, C., Fielden, C. A., & Kitterick, P. T. (2019). The Cost-Effectiveness of Bimodal Stimulation Compared to Unilateral and Bilateral Cochlear Implant Use in Adults with Bilateral Severe to Profound Deafness. Ear and Hearing, 40(6), 1425–1436. https://doi.org/10.1097/AUD.0000000000000727

Objectives: An increasing number of severe-profoundly deaf adult unilateral cochlear implant (CI) users receive bimodal stimulation; that is, they use a conventional acoustic hearing aid (HA) in their non-implanted ear. The combination of electric an... Read More about The Cost-Effectiveness of Bimodal Stimulation Compared to Unilateral and Bilateral Cochlear Implant Use in Adults with Bilateral Severe to Profound Deafness.

Posterior circulation stroke diagnosis using HINTS in patients presenting with acute vestibular syndrome: A systematic review (2019)
Journal Article
Krishnan, K., Bassilious, K., Eriksen, E., Bath, P. M., Sprigg, N., Brækken, S. K., …Sandset, E. C. (2019). Posterior circulation stroke diagnosis using HINTS in patients presenting with acute vestibular syndrome: A systematic review. European Stroke Journal, 4(3), 233-239. https://doi.org/10.1177/2396987319843701

Purpose
Acute vestibular syndrome – vertigo, nausea/vomiting, nystagmus and gait unsteadiness – is common, and differentiating posterior circulation stroke from a peripheral cause can be challenging. The National Institute of Health Stroke Scale (NI... Read More about Posterior circulation stroke diagnosis using HINTS in patients presenting with acute vestibular syndrome: A systematic review.

Women in the European Stroke Organisation: one, two, many… – A Top Down and Bottom Up approach (2019)
Journal Article
Sandset, E. C., de Sousa, D. A., Christensen, H., Cordonnier, C., Fischer, U., Katan, M., …Caso, V. (2019). Women in the European Stroke Organisation: one, two, many… – A Top Down and Bottom Up approach. European Stroke Journal, 4(3), 247-253. https://doi.org/10.1177/2396987319841979

Background: An increasing proportion of physicians are women, yet they still face challenges with career advancement. In 2014, the European Stroke Organisation established the goal of increasing the number and participation of women within the societ... Read More about Women in the European Stroke Organisation: one, two, many… – A Top Down and Bottom Up approach.

Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry (2019)
Journal Article
S Anderson, C., Robinson, T. G., Bray, B. D., Paley, L., Sprigg, N., Wang, X., …for the ENCHANTED Investigators and the SSNAP Collaboration. (2019). Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry. International Journal of Stroke, 14(7), 678-685. https://doi.org/10.1177/1747493019841246

© 2019 World Stroke Organization. Background: Randomized controlled trials provide high-level evidence, but the necessity to include selected patients may limit the generalisability of their results. Methods: Comparisons were made of baseline and out... Read More about Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry.

Magnetically Assisted Control of Stem Cells Applied in 2D, 3D and In Situ Models of Cell Migration (2019)
Journal Article
Harrison, R., Luckett, J., Marsh, S., Lugo Leija, H. A., Salih, S., Alkharji, R., & Sottile, V. (2019). Magnetically Assisted Control of Stem Cells Applied in 2D, 3D and In Situ Models of Cell Migration. Molecules, 24(8), Article 1563. https://doi.org/10.3390/molecules24081563

The success of cell therapy approaches is greatly dependent on the ability to precisely deliver and monitor transplanted stem cell grafts at treated sites. Iron oxide particles, traditionally used in vivo for magnetic resonance imaging (MRI), have be... Read More about Magnetically Assisted Control of Stem Cells Applied in 2D, 3D and In Situ Models of Cell Migration.

14th International Symposium on Thrombolysis, Thrombectomy and Acute Stroke Therapy: proceedings and summary of discussions (2019)
Journal Article
Sheth, S. A., Lopez-Rivera, V., Lee, S., Savitz, S. I., Liebeskind, D. S., Grotta, J. C., …Bath, P. (2019). 14th International Symposium on Thrombolysis, Thrombectomy and Acute Stroke Therapy: proceedings and summary of discussions. International Journal of Stroke, 14(4), 439-441. https://doi.org/10.1177/1747493019838760

The 14th International Symposium on Thrombolysis, Thrombectomy and Acute Stroke Therapy (TTST) took place in Houston, Texas on 21–22 October 2018. Attended by 150þ invited global experts, the objectives of TTST 2018 were to explore the changing lands... Read More about 14th International Symposium on Thrombolysis, Thrombectomy and Acute Stroke Therapy: proceedings and summary of discussions.

A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial (2019)
Journal Article
Hall, D., Ray, J., Watson, J., Sharman, A., Hutchison, J., Harris, P., …Large, C. H. (2019). A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial. Hearing Research, 377, 153-166. https://doi.org/10.1016/j.heares.2019.03.018

AUT00063 is an experimental new medicine that has been demonstrated to suppress spontaneous hyperactivity by modulating the action of voltage-gated potassium-channels in central auditory cortical neurons of a rodent model. This neurobiological proper... Read More about A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial.

Visual Speech Benefit in Clear and Degraded Speech Depends on the Auditory Intelligibility of the Talker and the Number of Background Talkers (2019)
Journal Article
Blackburn, C. L., Kitterick, P. T., Jones, G., Sumner, C. J., & Stacey, P. C. (2019). Visual Speech Benefit in Clear and Degraded Speech Depends on the Auditory Intelligibility of the Talker and the Number of Background Talkers. Trends in Hearing, 23, 1-14. https://doi.org/10.1177/2331216519837866

Perceiving speech in background noise presents a significant challenge to listeners. Intelligibility can be improved by seeing the face of a talker. This is of particular value to hearing impaired people and users of cochlear implants. It is well kno... Read More about Visual Speech Benefit in Clear and Degraded Speech Depends on the Auditory Intelligibility of the Talker and the Number of Background Talkers.