Background: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplat... Read More about Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.
All Outputs (120)
Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial (2017)
Journal Article
Rationale Aside from blood pressure lowering, treatment options for intracerebral haemorrhage remain limited and a proportion of patients will undergo early haematoma expansion with resultant significant morbidity and mortality. Tranexamic acid (T... Read More about Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial.
Nerve terminals at the human corneoscleral limbus (2017)
Journal Article
Aims: To demonstrate and characterise distinct subepithelial compact nerve endings (CNE) at the human corneoscleral limbus. Methods: Ten fresh human donor corneoscleral discs (mean age, 67 years) and 26 organ-cultured corneoscleral rims (mean age,... Read More about Nerve terminals at the human corneoscleral limbus.
Measuring Cerebral and Cerebellar Glutathione in Children Using 1H MEGA-PRESS MRS (2017)
Journal Article
Predictors of entering a hearing aid evaluation period: a prospective study in older hearing-help seekers (2017)
Journal Article
This study aimed to determine the predictors of entering a hearing aid evaluation period (HAEP) using a prospective design drawing on the health belief model and the transtheoretical model. In total, 377 older persons who presented with hearing probl... Read More about Predictors of entering a hearing aid evaluation period: a prospective study in older hearing-help seekers.
A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth (2017)
Journal Article
Predicting tumor growth and its response to therapy remains a major challenge in cancer research and strongly relies on tumor growth models. In this paper, we introduce, calibrate, and verify a novel image-driven reaction-diffusion model of avascular... Read More about A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth.
Quality of questionnaires for the assessment of otitis media with effusion in children (2017)
Journal Article
Objectives Audiometric tests provide information about hearing in otitis media with effusion (OME). Questionnaires can supplement this information by supporting clinical history‐taking as well as potentially providing a standardized and comprehensiv... Read More about Quality of questionnaires for the assessment of otitis media with effusion in children.
TICH-2 Trial – Tranexamic Acid for Intracerebral Haemorrhage 2 (2017)
Conference Proceeding
Rationale: To assess in a pragmatic phase III prospective double blind randomised placebo-controlled trial whether tranexamic acid is safe and reduces death or dependency after spontaneous intracerebral haemorrhage (SICH). The results will determine... Read More about TICH-2 Trial – Tranexamic Acid for Intracerebral Haemorrhage 2.
Survival of corneal nerve/sheath structures in organ-cultured donor corneas (2017)
Journal Article
Purpose To study the morphology of human corneal nerves in eye bank organ‐cultured corneas and in corneal grafts post‐transplantation. Methods Thirty‐seven organ‐cultured corneas were divided into: Group‐A, anterior 300–400 μm of 20 corneas used... Read More about Survival of corneal nerve/sheath structures in organ-cultured donor corneas.
Background: Cooling may reduce infarct size and improve neurological outcomes in patients with ischaemic stroke. In phase II trials, cooling awake patients with ischaemic stroke has been shown to be feasible and safe, but the effects in functional ou... Read More about Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke.
Gap-induced reductions of evoked potentials in the auditory cortex: a possible objective marker for the presence of tinnitus in animals (2017)
Journal Article
Animal models of tinnitus are essential for determining the underlying mechanisms and testing pharmacotherapies. However, there is doubt over the validity of current behavioural methods for detecting tinnitus. Here, we applied a stimulus paradigm wid... Read More about Gap-induced reductions of evoked potentials in the auditory cortex: a possible objective marker for the presence of tinnitus in animals.
The minimum monitoring signal-to-noise ratio for off-axis signals and its implications for directional hearing aids (2017)
Journal Article
The signal-to-noise ratio (SNR) benefit of hearing aid directional microphones is dependent on the angle of the listener relative to the target, something that can change drastically and dynamically in a typical group conversation. When a new target... Read More about The minimum monitoring signal-to-noise ratio for off-axis signals and its implications for directional hearing aids.
Background and purpose: Although poor prognosis after intracerebral haemorrhage relates to risk factors and haematoma characteristics, there is limited evidence for the effect of race-ethnicity. Methods: Data from 1011 patients with intracerebral ha... Read More about Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS).
Combined amplification and sound generation for tinnitus: a scoping review (2017)
Journal Article
Objectives: In most cases, tinnitus is accompanied by some degree of hearing loss. Current tinnitus management guidelines recognize the importance of addressing hearing difficulties, with hearing aids being a common option. Sound therapy is the prefe... Read More about Combined amplification and sound generation for tinnitus: a scoping review.
Problems and life effects experienced by tinnitus research study volunteers: an exploratory study using the ICF classification (2017)
Journal Article
Background: Tinnitus is one of the most distressing hearing-related symptoms. It is often associated with a range of physiological and psychological complications, such as depression, anxiety, and insomnia. Hence, approaching tinnitus from a biopsych... Read More about Problems and life effects experienced by tinnitus research study volunteers: an exploratory study using the ICF classification.
The psychological and social consequences of single-sided deafness in adulthood (2017)
Journal Article
Objectives: This study examined the subjective psychological and social effects of highly asymmetric hearing loss (single-sided deafness) in adults. Design: Three group interviews were conducted using the critical incidence technique and analysed us... Read More about The psychological and social consequences of single-sided deafness in adulthood.
Performance of the Tinnitus Functional Index as a diagnostic instrument in a UK clinical population (2017)
Journal Article
Objectives: The Tinnitus Functional Index (TFI) has been optimised as a diagnostic tool for quantifying the functional impact of tinnitus in US veteran and civilian groups. However, the TFI has not been evaluated for use in other English-speaking cl... Read More about Performance of the Tinnitus Functional Index as a diagnostic instrument in a UK clinical population.
Patterns of grey matter loss associated with motor subscores in early Parkinson's disease (2017)
Journal Article
Classical motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, and axial symptoms are graded in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III. It is yet to be ascertained whether... Read More about Patterns of grey matter loss associated with motor subscores in early Parkinson's disease.
Relations between self-reported daily-life fatigue, hearing status and pupil dilation during a speech perception in noise task (2017)
Journal Article
Objective: people with hearing impairment are likely to experience higher levels of fatigue due to effortful listening in daily communication. This hearing-related fatigue might not only constrain their work performance, but also result in withdrawal... Read More about Relations between self-reported daily-life fatigue, hearing status and pupil dilation during a speech perception in noise task.
Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation (2017)
Journal Article
Cannabidiol (CBD) and ?9-tetrahydrocannabinol (THC) have well documented immunomodulatory effects in vitro, but not following oral administration in humans. Here we show that oral co-administration of cannabinoids with lipids can substantially increa... Read More about Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation.