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All Outputs (106)

Preliminary assessment of the feasibility of using AB words to assess candidacy in adults (2016)
Journal Article
Vickers, D. A., Riley, A., Ricaud, R., Verschuur, C., Cooper, S., Nunn, T., …Kitterick, P. T. (in press). Preliminary assessment of the feasibility of using AB words to assess candidacy in adults. Cochlear Implants International, 17(sup 1), https://doi.org/10.1080/14670100.2016.1161143

Background: Adult cochlear implant (CI) candidacy is assessed in part by the use of speech perception measures. In the United Kingdom the current cut-off point to fall within the CI candidacy range is a score of less than 50% on the BKB sentences pre... Read More about Preliminary assessment of the feasibility of using AB words to assess candidacy in adults.

Parasympathetic nervous system dysfunction, as identified by pupil light reflex, and its possible connection to hearing impairment (2016)
Journal Article
Wang, Y., Zekveld, A. A., Naylor, G., Ohlenforst, B., Jansma, E. P., Lorens, A., …Kramer, S. E. (2016). Parasympathetic nervous system dysfunction, as identified by pupil light reflex, and its possible connection to hearing impairment. PLoS ONE, 11(4), Article e0153566. https://doi.org/10.1371/journal.pone.0153566

Context Although the pupil light reflex has been widely used as a clinical diagnostic tool for autonomic nervous system dysfunction, there is no systematic review available to summarize the evidence that the pupil light reflex is a sensitive method... Read More about Parasympathetic nervous system dysfunction, as identified by pupil light reflex, and its possible connection to hearing impairment.

Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen–plasmin system (2016)
Journal Article
Abdullah, Z., & Bayraktutan, U. (2016). Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen–plasmin system. BBA - Molecular Basis of Disease, 1862(7), 1354-1366. https://doi.org/10.1016/j.bbadis.2016.03.014

Ischaemic stroke, accompanied by neuroinflammation, impairs blood-brain barrier integrity through a complex mechanism involving both protein kinase C (PKC) and urokinase. Using an in vitro model of human blood-brain barrier (BBB) composed of brain mi... Read More about Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen–plasmin system.

On detectable and meaningful speech-intelligibility benefits (2016)
Journal Article
Whitmer, W. M., McShefferty, D., & Akeroyd, M. A. (in press). On detectable and meaningful speech-intelligibility benefits. Advances in Experimental Medicine and Biology, 894, https://doi.org/10.1007/978-3-319-25474-6_47

The most important parameter that affects the ability to hear and understand speech in the presence of background noise is the signal-to-noise ratio (SNR). Despite decades of research in speech intelligibility, it is not currently known how much impr... Read More about On detectable and meaningful speech-intelligibility benefits.

The contribution of visual information to the perception of speech in noise with and without informative temporal fine structure (2016)
Journal Article
Stacey, P. C., Kitterick, P. T., Morris, S. D., & Sumner, C. J. (2016). The contribution of visual information to the perception of speech in noise with and without informative temporal fine structure. Hearing Research, 336, 17-28. https://doi.org/10.1016/j.heares.2016.04.002

Understanding what is said in demanding listening situations is assisted greatly by looking at the face of a talker. Previous studies have observed that normal-hearing listeners can benefit from this visual information when a talker’s voice is presen... Read More about The contribution of visual information to the perception of speech in noise with and without informative temporal fine structure.

White matter microstructural changes in adolescent anorexia nervosa including an exploratory longitudinal study (2016)
Journal Article
Vogel, K., Timmers, I., Kumar, V., Nickl-Jockschat, T., Bastiani, M., Roebroek, A., …Seitz, J. (2016). White matter microstructural changes in adolescent anorexia nervosa including an exploratory longitudinal study. NeuroImage: Clinical, 11, 614-621. https://doi.org/10.1016/j.nicl.2016.04.002

Background Anorexia nervosa (AN) often begins in adolescence, however, the understanding of the underlying pathophysiology at this developmentally important age is scarce, impeding early interventions. We used diffusion tensor imaging (DTI) to inv... Read More about White matter microstructural changes in adolescent anorexia nervosa including an exploratory longitudinal study.

Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain (2016)
Journal Article
Abaei, M., Sagar, D. R., Stockley, E. G., Spicer, C. H., Prior, M., Chapman, V., & Auer, D. P. (in press). Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain. Molecular Pain, 12, https://doi.org/10.1177/1744806916642445

Background: The mechanisms driving osteoarthritic pain remain poorly understood, but there is increasing evidence for a role of the central nervous system in the chronification of pain.We used functional magnetic resonance imaging to investigate the... Read More about Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain.

Contralateral acoustic hearing aid use in adult unilateral cochlear implant recipients: current provision, practice, and clinical experience in the UK (2016)
Journal Article
Fielden, C. A., & Kitterick, P. T. (in press). Contralateral acoustic hearing aid use in adult unilateral cochlear implant recipients: current provision, practice, and clinical experience in the UK. Cochlear Implants International, 17(3), https://doi.org/10.1080/14670100.2016.1162382

Objectives: The study surveyed practising cochlear implant audiologists with the aim of: (1) characterising UK clinical practice around the management and fitting of a contralateral hearing aid in adult unilateral cochlear implant users (‘bimodal aid... Read More about Contralateral acoustic hearing aid use in adult unilateral cochlear implant recipients: current provision, practice, and clinical experience in the UK.

Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: protocol for a randomized, placebo-controlled trial (2016)
Journal Article
Sprigg, N., Robson, K., Bath, P. M., Dineen, R. A., Roberts, I., Robinson, T., …Beredzie, M. (2016). Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: protocol for a randomized, placebo-controlled trial. International Journal of Stroke, 11(6), https://doi.org/10.1177/1747493016641960

Rationale: Outcome after intracerebral hemorrhage remains poor. Tranexamic acid is easy to administer, readily available, inexpensive, and effective in other hemorrhagic conditions. Aim: This randomized trial aims to test the hypothesis that intra... Read More about Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: protocol for a randomized, placebo-controlled trial.

A randomized controlled trial to evaluate the benefits of a multimedia educational program for first-time hearing aid users (2016)
Journal Article
Ferguson, M. A., Brandreth, M., Brassington, W., Leighton, P., & Wharrad, H. (2016). A randomized controlled trial to evaluate the benefits of a multimedia educational program for first-time hearing aid users. Ear and Hearing, 37(2), https://doi.org/10.1097/AUD.0000000000000237

Objectives: The aims of this study were to (1) develop a series of short interactive videos (or reusable learning objects [RLOs]) covering a broad range of practical and psychosocial issues relevant to the auditory rehabilitation for first-time heari... Read More about A randomized controlled trial to evaluate the benefits of a multimedia educational program for first-time hearing aid users.

Scrolling Characteristics of Pre-Descemet Endothelial Keratoplasty Tissue: An Ex Vivo Study (2016)
Journal Article
Dua, H., Termote, K., Kenawy, M., Said, D., Jayaswal, R., Nubile, M., …Holland, S. (2016). Scrolling Characteristics of Pre-Descemet Endothelial Keratoplasty Tissue: An Ex Vivo Study. American Journal of Ophthalmology, 166, 84-90. https://doi.org/10.1016/j.ajo.2016.03.034

Purpose To evaluate the scrolling propensity of pre-Descemet endothelial keratoplasty (PDEK) tissue and to compare it with each component of the PDEK tissue, namely the pre-Descemet layer (Dua's layer [PDL]) and the Descemet membrane (DM). Desi... Read More about Scrolling Characteristics of Pre-Descemet Endothelial Keratoplasty Tissue: An Ex Vivo Study.

Can illness beliefs, from the common-sense model, prospectively predict adherence to self-management behaviours?: a systematic review and meta-analysis (2016)
Journal Article
Aujla, N., Walker, M., Sprigg, N., Abrams, K., Massey, A., & Vedhara, K. (in press). Can illness beliefs, from the common-sense model, prospectively predict adherence to self-management behaviours?: a systematic review and meta-analysis. Psychology and Health, 2016, https://doi.org/10.1080/08870446.2016.1153640

Objective: To determine whether people’s beliefs about their illness, conceptualised by the common sense model (CSM), can prospectively predict adherence to self-management behaviours (including, attendance, medication, diet and exercise) in adults w... Read More about Can illness beliefs, from the common-sense model, prospectively predict adherence to self-management behaviours?: a systematic review and meta-analysis.

The Glasgow Bene?t Inventory: a systematic review of the use and value of an otorhinolaryngological generic patient-recorded outcome measure (2016)
Journal Article
Hendry, J., Chin, A., Swan, I. R., Akeroyd, M. A., & Browning, G. G. (2016). The Glasgow Bene?t Inventory: a systematic review of the use and value of an otorhinolaryngological generic patient-recorded outcome measure. Clinical Otolaryngology, 41(3), https://doi.org/10.1111/coa.12518

The Glasgow Benefit Inventory (GBI) is a validated, generic patient-recorded outcome measure widely used in otolaryngology to report change in quality of life post-intervention.To date, no systematic review has made (i) a quality assessment of report... Read More about The Glasgow Bene?t Inventory: a systematic review of the use and value of an otorhinolaryngological generic patient-recorded outcome measure.

Understanding User Reactions and Interactions with an Internet-Based Intervention for Tinnitus Self-Management: Mixed-Methods Process Evaluation (2016)
Other
Greenwell, K., Sereda, M., Coulson, N., & Hoare, D. J. (2016). Understanding User Reactions and Interactions with an Internet-Based Intervention for Tinnitus Self-Management: Mixed-Methods Process Evaluation

Background: Tinnitus is a common symptom that can affect an individual’s quality of life, requiring psychological support that is not readily accessible. Internet-based interventions have the potential to reduce the disparity in access to psycholo... Read More about Understanding User Reactions and Interactions with an Internet-Based Intervention for Tinnitus Self-Management: Mixed-Methods Process Evaluation.

Prediction of 30-day mortality after hip fracture surgery by the Nottingham Hip Fracture Score and the Surgical Outcome Risk Tool (2016)
Journal Article
Marufu, T. C., White, S., Griffiths, R., Moonesinghe, S., & Moppett, I. K. (in press). Prediction of 30-day mortality after hip fracture surgery by the Nottingham Hip Fracture Score and the Surgical Outcome Risk Tool. Anaesthesia, 71(5), https://doi.org/10.1111/anae.13418

The care of the elderly with hip fractures and their outcomes might be improved with resources targeted by the accurate calculation of risks of mortality and morbidity. We used a multicentre national dataset to evaluate and recalibrate the Nottingham... Read More about Prediction of 30-day mortality after hip fracture surgery by the Nottingham Hip Fracture Score and the Surgical Outcome Risk Tool.

Secondary analysis of outcomes after 11,085 hip fracture operations from the prospective UK Anaesthesia Sprint Audit of Practice (ASAP-2) (2016)
Journal Article
White, S., Moppett, I., Griffiths, R., Johansen, A., Wakeman, R., Boulton, C., …Grocott, M. (2016). Secondary analysis of outcomes after 11,085 hip fracture operations from the prospective UK Anaesthesia Sprint Audit of Practice (ASAP-2). Anaesthesia, 71(5), https://doi.org/10.1111/anae.13415

We re-analysed prospective data collected by anaesthetists in the Anaesthesia Sprint Audit of Practice (ASAP-1) to describe associations with linked outcome data. Mortality was 165/11,085 (1.5%) 5 days and 563/11,085 (5.1%) 30 days after surgery and... Read More about Secondary analysis of outcomes after 11,085 hip fracture operations from the prospective UK Anaesthesia Sprint Audit of Practice (ASAP-2).

A nuclear magnetic resonance study of water in aggrecan solutions (2016)
Journal Article
Foster, R. J., Damion, R. A., Baboolal, T. G., Smye, S. W., & Ries, M. E. (2016). A nuclear magnetic resonance study of water in aggrecan solutions. Royal Society Open Science, 3(3), https://doi.org/10.1098/rsos.150705

Aggrecan, a highly charged macromolecule found in articular cartilage, was investigated in aqueous salt solutions with proton nuclear magnetic resonance. The longitudinal and transverse relaxation rates were determined at two different field strength... Read More about A nuclear magnetic resonance study of water in aggrecan solutions.

Motivational engagement in first-time hearing aid users: a feasibility study (2016)
Journal Article
Ferguson, M. A., Maidment, D., Russell, N., Gregory, M., & Nicholson, R. (in press). Motivational engagement in first-time hearing aid users: a feasibility study. International Journal of Audiology, 55(sup3), Article S23-S33. https://doi.org/10.3109/14992027.2015.1133935

Objective: To assess (1) the feasibility of incorporating the Ida Institute’s Motivation Tools into a UK audiology service, (2) the potential benefits of motivational engagement in first-time hearing aid users, and (3) predictors of hearing aid and g... Read More about Motivational engagement in first-time hearing aid users: a feasibility study.

Behavioural estimates of auditory filter widths in ferrets using notched-noise maskers (2016)
Journal Article
Sumner, C., Alves-Pinto, A., Sollini, J., & Wells, T. (2016). Behavioural estimates of auditory filter widths in ferrets using notched-noise maskers. Journal of the Acoustical Society of America, 139(2), EL19-EL24. https://doi.org/10.1121/1.4941772

Frequency selectivity is a fundamental property of hearing which affects almost all aspects of auditory processing. Here auditory filter widths at 1, 3, 7, and 10 kHz were estimated from behavioural thresholds using the notched-noise method [Patterso... Read More about Behavioural estimates of auditory filter widths in ferrets using notched-noise maskers.