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Bioluminescence imaging of stroke-induced endogenous neural stem cell response (2014)
Journal Article
Vandeputte, C., Reumers, V., Aelvoet, S.-A., Thiry, I., De Swaef, S., Van den Haute, C., Pascual-Brazo, J., Farr, T. D., Vande Velde, G., Hoehn, M., Himmelreich, U., Van Laere, K., Debyser, Z., Gijsbers, R., & Baekelandt, V. (2014). Bioluminescence imaging of stroke-induced endogenous neural stem cell response. Neurobiology of Disease, 69, https://doi.org/10.1016/j.nbd.2014.05.014

Brain injury following stroke affects neurogenesis in the adult mammalian brain. However, a complete under¬standing of the origin and fate of the endogenous neural stem cells (eNSCs) in vivo is missing. Tools and technol¬ogy that allow non-invasive i... Read More about Bioluminescence imaging of stroke-induced endogenous neural stem cell response.

Cost-effectiveness of classroom-based cognitive behaviour therapy in reducing symptoms of depression in adolescents: a trial-based analysis (2014)
Journal Article
Anderson, R., Ukoumunne, O. C., Sayal, K., Phillips, R., Taylor, J. A., Spears, M., Araya, R., Lewis, G., Montgomery, A. A., & Stallard, P. (2014). Cost-effectiveness of classroom-based cognitive behaviour therapy in reducing symptoms of depression in adolescents: a trial-based analysis. Journal of Child Psychology and Psychiatry, 55(12), 1390-1397. https://doi.org/10.1111/jcpp.12248

Background

A substantial minority of adolescents suffer from depression and it is associated with increased risk of suicide, social and educational impairment, and mental health problems in adulthood. A recently conducted randomized controlled tri... Read More about Cost-effectiveness of classroom-based cognitive behaviour therapy in reducing symptoms of depression in adolescents: a trial-based analysis.

Assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments (2014)
Journal Article
Langers, D. R. (2014). Assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments. Human Brain Mapping, 35(4), https://doi.org/10.1002/hbm.22272

Although orderly representations of sound frequency in the brain play a guiding role in the investigation of auditory processing, a rigorous statistical evaluation of cortical tonotopic maps has so far hardly been attempted. In this report, the group... Read More about Assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments.

Tranexamic acid for spontaneous intracerebral hemorrhage: a randomized controlled pilot trial (ISRCTN50867461) (2014)
Journal Article
a randomized controlled pilot trial (ISRCTN50867461). Journal of Stroke and Cerebrovascular Diseases, 23(6), 1312-1318. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.11.007

Background: Spontaneous intracerebral hemorrhage (ICH) can be devastating, particularly if hematoma expansion (HE) occurs. Tranexamic acid (TA), an antifibrinolytic drug, significantly reduced mortality in bleeding patients after trauma in the large... Read More about Tranexamic acid for spontaneous intracerebral hemorrhage: a randomized controlled pilot trial (ISRCTN50867461).

Comparative analysis of the macroscale structural connectivity in the macaque and human brain (2014)
Journal Article
Goulas, A., Bastiani, M., Bezgin, G., Uylings, H. B., Roebroeck, A., & Stiers, P. (2014). Comparative analysis of the macroscale structural connectivity in the macaque and human brain. PLoS Computational Biology, 10(3), Article e1003529. https://doi.org/10.1371/journal.pcbi.1003529

The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of th... Read More about Comparative analysis of the macroscale structural connectivity in the macaque and human brain.

Pre-Descemet's endothelial keratoplasty (PDEK) (2014)
Journal Article
Dua, H., Agarwal, A., Narang, P., Kumar, D. A., Agarwal, A., Jacob, S., Agarwal, A., & Gupta, A. (2014). Pre-Descemet's endothelial keratoplasty (PDEK). British Journal of Ophthalmology, 98(9), 1181-1185. https://doi.org/10.1136/bjophthalmol-2013-304639

A new surgical technique for endothelial keratoplasty is described, in which the composite of pre-Descemet's layer (Dua's layer) with Descemet's membrane and endothelium is transplanted subsequent to the removal of the recipient's Descemet's membrane... Read More about Pre-Descemet's endothelial keratoplasty (PDEK).

Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase (2014)
Journal Article
Rakkar, K., Srivastava, K., & Bayraktutan, U. (2014). Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase. European Journal of Neuroscience, 39(12), https://doi.org/10.1111/ejn.12552

Ischaemic injury impairs the integrity of the blood–brain barrier (BBB). In this study, we investigated the molecular causes of this defect with regard to the putative correlations among NAD(P)H oxidase, plasminogen–plasmin system components, and mat... Read More about Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase.

Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions (2014)
Journal Article
Gibson, C. L., Srivastava, K., Sprigg, N., Bath, P. M., & Bayrakutan, U. (in press). Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions. Journal of Neurochemistry, 129(5), https://doi.org/10.1111/jnc.12681

Ischaemic strokes evoke blood–brain barrier (BBB) disruption and oedema formation through a series of mechanisms involving Rho-kinase activation. Using an animal model of human focal cerebral ischaemia, this study assessed and confirmed the therapeut... Read More about Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions.

A method for measuring the intelligibility of uninterrupted, continuous speech (2014)
Journal Article
MacPherson, A., & Akeroyd, M. A. (2014). A method for measuring the intelligibility of uninterrupted, continuous speech. Journal of the Acoustical Society of America, 135(3), 1027-1030. https://doi.org/10.1121/1.4863657

Speech-in-noise tests commonly use short, discrete sentences as representative samples of everyday speech. These tests cannot, however, fully represent the added demands of understanding ongoing, linguistically complex speech. Using a new monitoring... Read More about A method for measuring the intelligibility of uninterrupted, continuous speech.

Statistical analysis plan for the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial (2014)
Journal Article
Bath, P. M., Houlton, A., Woodhouse, L. J., Sprigg, N., Wardlaw, J. M., & Pocock, S. J. (in press). Statistical analysis plan for the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial. International Journal of Stroke, 9(3), https://doi.org/10.1111/ijs.12235

High blood pressure is common during the acute phase of stroke and is associated with a poor outcome. However, the management of high blood pressure remains unclear. The ‘Efficacy of Nitric Oxide in Stroke’ trial tested whether transdermal glyceryl t... Read More about Statistical analysis plan for the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial.

The effect of hyperglycaemia on permeability and the expression of junctional complex molecules in human retinal and choroidal endothelial cells. (2014)
Journal Article
Amoaku, W., Saker, S., Stewart, E. A., Browning, A. C., & Allen, C. L. (2014). The effect of hyperglycaemia on permeability and the expression of junctional complex molecules in human retinal and choroidal endothelial cells. Experimental Eye Research, 121, 161-167. https://doi.org/10.1016/j.exer.2014.02.016

Diabetic retinopathy is the leading cause of preventable blindness in the working population and its prevalence continues to increase as the worldwide prevalence of diabetes grows. Diabetic choroidopathy is less well studied and occurs in the late st... Read More about The effect of hyperglycaemia on permeability and the expression of junctional complex molecules in human retinal and choroidal endothelial cells..

Collagen cross-linking with photoactivated riboflavin (PACK-CXL) for the treatment of advanced infectious keratitis with corneal melting (2014)
Journal Article
Dua, H., Said, D., Elalfy, M., Gatzioufas, Z., El-Zakzouk, E., Hassan, M., Saif, M., Zaki, A., & Hafezi, F. (2014). Collagen cross-linking with photoactivated riboflavin (PACK-CXL) for the treatment of advanced infectious keratitis with corneal melting. Ophthalmology: Journal of The American Academy of Ophthalmology, 121(7), 1377-1382. https://doi.org/10.1016/j.ophtha.2014.01.011

Concise review: evidence for CD34 as a common marker for diverse progenitors (2014)
Journal Article
Sidney, L. E., Branch, M. J., Dunphy, S. E., Dua, H. S., & Hopkinson, A. (2014). Concise review: evidence for CD34 as a common marker for diverse progenitors. STEM CELLS, 32(6), 1380-1389. https://doi.org/10.1002/stem.1661

CD34 is a transmembrane phosphoglycoprotein, first identified on hematopoietic stem and progenitor cells. Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Due to these historical... Read More about Concise review: evidence for CD34 as a common marker for diverse progenitors.