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Comparative analysis of the macroscale structural connectivity in the macaque and human brain

Goulas, Alexandros; Bastiani, Matteo; Bezgin, Gleb; Uylings, Harry B.M.; Roebroeck, Alard; Stiers, Peter

Authors

Alexandros Goulas

Gleb Bezgin

Harry B.M. Uylings

Alard Roebroeck

Peter Stiers



Contributors

Claus C. Hilgetag
Editor

Abstract

The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.

Journal Article Type Article
Publication Date Mar 27, 2014
Journal PLoS Computational Biology
Print ISSN 1553-734X
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 10
Issue 3
Article Number e1003529
APA6 Citation Goulas, A., Bastiani, M., Bezgin, G., Uylings, H. B., Roebroeck, A., & Stiers, P. (2014). Comparative analysis of the macroscale structural connectivity in the macaque and human brain. PLoS Computational Biology, 10(3), https://doi.org/10.1371/journal.pcbi.1003529
DOI https://doi.org/10.1371/journal.pcbi.1003529
Publisher URL https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003529

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