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Comparative analysis of the macroscale structural connectivity in the macaque and human brain

Goulas, Alexandros; Bastiani, Matteo; Bezgin, Gleb; Uylings, Harry B.M.; Roebroeck, Alard; Stiers, Peter

Authors

Alexandros Goulas

Matteo Bastiani

Gleb Bezgin

Harry B.M. Uylings

Alard Roebroeck

Peter Stiers



Contributors

Claus C. Hilgetag
Editor

Abstract

The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.

Citation

Goulas, A., Bastiani, M., Bezgin, G., Uylings, H. B., Roebroeck, A., & Stiers, P. (2014). Comparative analysis of the macroscale structural connectivity in the macaque and human brain. PLoS Computational Biology, 10(3), https://doi.org/10.1371/journal.pcbi.1003529

Journal Article Type Article
Acceptance Date Feb 7, 2014
Online Publication Date Mar 27, 2014
Publication Date Mar 27, 2014
Deposit Date Oct 15, 2018
Publicly Available Date Oct 15, 2018
Journal PLoS Computational Biology
Print ISSN 1553-734X
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 10
Issue 3
Article Number e1003529
DOI https://doi.org/10.1371/journal.pcbi.1003529
Public URL https://nottingham-repository.worktribe.com/output/1164635
Publisher URL https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003529

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