Alexandros Goulas
Comparative analysis of the macroscale structural connectivity in the macaque and human brain
Goulas, Alexandros; Bastiani, Matteo; Bezgin, Gleb; Uylings, Harry B.M.; Roebroeck, Alard; Stiers, Peter
Authors
Matteo Bastiani
Gleb Bezgin
Harry B.M. Uylings
Alard Roebroeck
Peter Stiers
Contributors
Claus C. Hilgetag
Editor
Abstract
The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 7, 2014 |
Online Publication Date | Mar 27, 2014 |
Publication Date | Mar 27, 2014 |
Deposit Date | Oct 15, 2018 |
Publicly Available Date | Oct 15, 2018 |
Journal | PLoS Computational Biology |
Print ISSN | 1553-734X |
Publisher | Public Library of Science |
Peer Reviewed | Peer Reviewed |
Volume | 10 |
Issue | 3 |
Article Number | e1003529 |
DOI | https://doi.org/10.1371/journal.pcbi.1003529 |
Public URL | https://nottingham-repository.worktribe.com/output/1164635 |
Publisher URL | https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003529 |
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journal.pcbi.1003529
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https://creativecommons.org/licenses/by/4.0/
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