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All Outputs (1069)

Clinical management of cerebral small vessel disease: a call for a holistic approach (2020)
Journal Article
Clancy, U., Appleton, J. P., Arteaga, C., Doubal, F. N., Bath, P. M., & Wardlaw, J. M. (2021). Clinical management of cerebral small vessel disease: a call for a holistic approach. Chinese Medical Journal, 134(2), 127-142. https://doi.org/10.1097/cm9.0000000000001177

Cerebral small vessel disease (SVD) is a common global brain disease that causes cognitive impairment, ischemic or hemorrhagic stroke, problems with mobility, and neuropsychiatric symptoms. The brain damage, seen as focal white and deep grey matter l... Read More about Clinical management of cerebral small vessel disease: a call for a holistic approach.

Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners (2020)
Journal Article
Smith, L., Elwick, H., Mhizha-Murira, J., Topcu, G., Bale, C., Evangelou, N., …Das Nair, R. (2021). Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners. Multiple Sclerosis and Related Disorders, 49, Article 102563. https://doi.org/10.1016/j.msard.2020.102563

Background: Cognitive problems are a common and debilitating symptom of multiple sclerosis (MS). Screening and treatment for cognitive problems are recommended, however these are not routinely delivered in UK clinics. We collected and synthesised... Read More about Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners.

Tinnitus and stress in adults: a scoping review (2020)
Journal Article
Elarbed, A., Fackrell, K., Baguley, D. M., & Hoare, D. J. (2021). Tinnitus and stress in adults: a scoping review. International Journal of Audiology, 60(3), 171-182. https://doi.org/10.1080/14992027.2020.1827306

Objective Tinnitus and stress are recurrently reported together. The strength and direction of this relationship is not clear. The aim of this review is to catalogue the evidence of this relationship, how it has been described in adults and which in... Read More about Tinnitus and stress in adults: a scoping review.

A scoping review of psychoeducational interventions for people after transient ischemic attack and minor stroke (2020)
Journal Article
Kontou, E., Kettlewell, J., Condon, L., Thomas, S., Lee, A. R., Sprigg, N., …Shokraneh, F. (2021). A scoping review of psychoeducational interventions for people after transient ischemic attack and minor stroke. Topics in Stroke Rehabilitation, 28(5), 390-400. https://doi.org/10.1080/10749357.2020.1818473

Background: Psychoeducation can provide information and support to cope with the physical and emotional effects of a health condition. This scoping review aimed to identify the evidence regarding psychoeducational interventions for people after a Tra... Read More about A scoping review of psychoeducational interventions for people after transient ischemic attack and minor stroke.

Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel (2020)
Journal Article
Appleton, J. P., Richardson, C., Dovlatova, N., May, J., Sprigg, N., Heptinstall, S., & Bath, P. M. (2021). Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel. Stroke and Vascular Neurology, 6(1), 103-108. https://doi.org/10.1136/svn-2020-000346

Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients, in part because of treatment resistance. The primary aim was to assess the proportion of patients who are insensitive to clopidogrel. The... Read More about Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel.

Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus (2020)
Journal Article
Basso, L., Boecking, B., Brueggemann, P., Pedersen, N. L., Canlon, B., Cederroth, C. R., & Mazurek, B. (2020). Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus. Frontiers in Neuroscience, 14, Article 706. https://doi.org/10.3389/fnins.2020.00706

Objective: This study aims to identify gender-specific risk factors associated with the presence of bothersome tinnitus (compared with non-bothersome tinnitus), including sociodemographic and lifestyle factors, tinnitus-associated phenomena (hearing... Read More about Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus.

Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews (2020)
Journal Article
Topcu, G., Griffiths, H., Bale, C., Trigg, E., Clarke, S., Potter, K.-J., …das Nair, R. (2020). Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews. Clinical Psychology Review, 82, Article 101923. https://doi.org/10.1016/j.cpr.2020.101923

This meta-review aimed to synthesise evidence on psychosocial adjustment to multiple sclerosis, to identify available treatment models and services for recently diagnosed individuals, and to explore their effectiveness. MEDLINE, CINAHL, EMBASE, PsycI... Read More about Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews.

The Content and Quality of Information About Hyperacusis Presented Online (2020)
Journal Article
Smith, S. N., Smallwood, E., Sereda, M., Adams, B., & Hoare, D. J. (2020). The Content and Quality of Information About Hyperacusis Presented Online. American Journal of Audiology, 29(3S), 623-630. https://doi.org/10.1044/2020_aja-19-00074

© 2020 American Speech-Language-Hearing Association. Purpose: Hyperacusis is a disorder characterized by reduced sound tolerance leading to ear pain, emotional distress, and reduced quality of life. Many people with hyperacusis turn to the Internet f... Read More about The Content and Quality of Information About Hyperacusis Presented Online.

In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications (2020)
Journal Article
Das, A., Saffaran, S., Chikhani, M., Scott, T. E., Laviola, M., Yehya, N., …Bates, D. G. (2020). In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications. Critical Care Explorations, 2(9), Article e0202. https://doi.org/10.1097/CCE.0000000000000202

Objectives: Patients with COVID-19 Acute Respiratory Distress Syndrome (CARDS) appear to present with at least two distinct phenotypes: severe hypoxemia with relatively well-preserved lung compliance and lung gas volumes (Type 1) and a more conventio... Read More about In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications.

The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants (2020)
Journal Article
Knipper, M., Van Dijk, P., Schulze, H., Mazurek, B., Krauss, P., Scheper, V., …Rüttiger, L. (2020). The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants. Journal of Neuroscience, 40(38), 7190-7202. https://doi.org/10.1523/JNEUROSCI.1314-19.2020

Subjective tinnitus is the conscious perception of sound in the absence of any acoustic source. The literature suggests various tinnitus mechanisms, most of which invoke changes in spontaneous firing rates of central auditory neurons resulting from m... Read More about The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants.

A Comparison of T2 Relaxation-Based MRI Stroke Timing Methods in Hyperacute Ischemic Stroke Patients: A Pilot Study (2020)
Journal Article
McGarry, B. L., Damion, R. A., Chew, I., Knight, M. J., Harston, G. W., Carone, D., …Kauppinen, R. A. (2020). A Comparison of T2 Relaxation-Based MRI Stroke Timing Methods in Hyperacute Ischemic Stroke Patients: A Pilot Study. Journal of Central Nervous System Disease, 12, https://doi.org/10.1177/1179573520943314

Background: T2 relaxation-based magnetic resonance imaging (MRI) signals may provide onset time for acute ischemic strokes with an unknown onset. The ability of visual and quantitative MRI-based methods in a cohort of hyperacute ischemic stroke patie... Read More about A Comparison of T2 Relaxation-Based MRI Stroke Timing Methods in Hyperacute Ischemic Stroke Patients: A Pilot Study.

Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial (2020)
Journal Article
Kang Law, Z., Dineen, R., England, T. J., Cala, L., Mistri, A. K., Appleton, J. P., …TICH-2 investigators. (2021). Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial. Translational Stroke Research, 12, 275-283. https://doi.org/10.1007/s12975-020-00845-6

Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological deterioration and whether tranexamic acid reduced the risk of neurological deterioration. Data from the Tranexa... Read More about Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial.

Data sharing: experience of accessing individual patient data from completed randomised controlled trials in vascular and cognitive medicine (2020)
Journal Article
Scutt, P., Woodhouse, L. J., Montgomery, A. A., & Bath, P. M. .. (2020). Data sharing: experience of accessing individual patient data from completed randomised controlled trials in vascular and cognitive medicine. BMJ Open, 10(9), Article e038765. https://doi.org/10.1136/bmjopen-2020-038765

Objectives Meta-analysis based on individual patient data (IPD) from randomised trials is superior to using published summary data since it facilitates subgroup and multiple variable analyses. Guidelines and funders expect that researchers share IPD... Read More about Data sharing: experience of accessing individual patient data from completed randomised controlled trials in vascular and cognitive medicine.

Auditory dysfunction in type 2 Stickler Syndrome (2020)
Journal Article
Alexander, P., Gomersall, P., Stancel-Lewis, J., Fincham, G. S., Poulson, A., Richards, A., …Snead, M. (2021). Auditory dysfunction in type 2 Stickler Syndrome. European Archives of Oto-Rhino-Laryngology, 278, 2261-2268. https://doi.org/10.1007/s00405-020-06306-y

Purpose To present the extent and site of lesion of auditory dysfunction in a large cohort of individuals with type 2 Stickler Syndrome. Type 2 Stickler syndrome results from a mutation in the gene coding for α-1 type XI pro-collagen, which has been... Read More about Auditory dysfunction in type 2 Stickler Syndrome.

Corticocortical and Thalamocortical Changes in Functional Connectivity and White Matter Structural Integrity after Reward-Guided Learning of Visuospatial Discriminations in Rhesus Monkeys (2020)
Journal Article
Pelekanos, V., Premereur, E., Mitchell, D. J., Chakraborty, S., Mason, S., Lee, A. C., & Mitchell, A. S. (2020). Corticocortical and Thalamocortical Changes in Functional Connectivity and White Matter Structural Integrity after Reward-Guided Learning of Visuospatial Discriminations in Rhesus Monkeys. Journal of Neuroscience, 40(41), 7887-7901. https://doi.org/10.1523/jneurosci.0364-20.2020

The frontal cortex and temporal lobes together regulate complex learning and memory capabilities. Here, we collected resting-state functional and diffusion-weighted MRI data before and after male rhesus macaque monkeys received extensive training to... Read More about Corticocortical and Thalamocortical Changes in Functional Connectivity and White Matter Structural Integrity after Reward-Guided Learning of Visuospatial Discriminations in Rhesus Monkeys.

Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders (2020)
Journal Article
Beeken, L. J., Ting, D. S. J., & Sidney, L. E. (2020). Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders. Stem Cells Translational Medicine, 10(1), 39-49. https://doi.org/10.1002/sctm.20-0118

Ocular surface inflammatory disorders (OSIDs) are a group of highly prevalent, heterogeneous diseases which display a variety of aetiologies and symptoms and are risk factors for serious complications including ocular and cornea impairment. Corneal i... Read More about Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders.

The impact of video games on ultrasound-guided regional anesthesia skills (2020)
Journal Article
Shafqat, A., Mukarram, S., Bedforth, N. M., Hardman, J. G., & Mccahon, R. A. (2020). The impact of video games on ultrasound-guided regional anesthesia skills. Regional Anesthesia and Pain Medicine, 45(11), 860-865. https://doi.org/10.1136/rapm-2020-101641

Background: There is an association between video game practice and laparoscopic expertise in trainee surgeons. Ultrasound-guided regional anesthesia has many parallels with laparoscopic surgery. The aim of this study was to explore whether video gam... Read More about The impact of video games on ultrasound-guided regional anesthesia skills.

WHIRL Study: Workplace Health Interprofessional Learning in the Construction Industry (2020)
Journal Article
Blake, H., Somerset, S., Whittingham, K., Middleton, M., Yildirim, M., & Evans, C. (2020). WHIRL Study: Workplace Health Interprofessional Learning in the Construction Industry. International Journal of Environmental Research and Public Health, 17(18), Article 6815. https://doi.org/10.3390/ijerph17186815

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Interprofessional learning (IPL) is essential to prepare healthcare trainees as the future public health workforce. WHIRL (Workplace Health InteRprofessional Learning) was an innovative IPL in... Read More about WHIRL Study: Workplace Health Interprofessional Learning in the Construction Industry.

Antimicrobial peptides in human corneal tissue of patients with fungal keratitis (2020)
Journal Article
Mohammed, I., Mohanty, D., Said, D. G., Barik, M. R., Reddy, M. M., Alsaadi, A., …Mittal, R. (2021). Antimicrobial peptides in human corneal tissue of patients with fungal keratitis. British Journal of Ophthalmology, 105(8), 1172-1177. https://doi.org/10.1136/bjophthalmol-2020-316329

Background Fungal keratitis (FK) is the leading cause of unilateral blindness in the developing world. Antimicrobial peptides (AMPs) have been shown to play an important role on human ocular surface (OS) during bacterial, viral and protozoan infectio... Read More about Antimicrobial peptides in human corneal tissue of patients with fungal keratitis.