All Outputs (12)

Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk (2008)
Journal Article

Objectives: Our aim was to study the effect of combination therapy with aspirin and dipyridamole (A+D) over aspirin alone (ASA) in secondary prevention after transient ischemic attack or minor stroke of presumed arterial origin and to perform subgr... Read More about Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk.

Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events (2008)
Journal Article

Background Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin–angiotensin system in high-risk patients reduces the rate of subsequent cardiovascular events, including str... Read More about Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events.

Effects of Antioxidants on Endothelial Function in Human Saphenous Vein in an Ex vivo Model (2008)
Journal Article

Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke (2008)
Journal Article

Background: Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens — aspirin plus extended release dipyridamole (ASA–ERDP) versus clopidogrel. Methods: In this... Read More about Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke.

Use of ordinal outcomes in vascular prevention trials: comparison with binary outcomes in published trials (2008)
Journal Article

Background and Purpose—Vascular prevention trials mostly count “yes/no” (binary) outcome events, eg, stroke/no stroke. Analysis of ordered categorical vascular events (eg, fatal stroke/nonfatal stroke/no stroke) is clinically relevant and could be... Read More about Use of ordinal outcomes in vascular prevention trials: comparison with binary outcomes in published trials.

Ordinal reanalysis of the SHEP Trial (2008)
Journal Article

Calculation of sample size for stroke trials assessing functional outcome: comparison of binary and ordinal approaches (2008)
Journal Article

Background Many acute stroke trials have given neutral results. Sub-optimal statistical analyses may be failing to detect efficacy. Methods which take account of the ordinal nature of functional outcome data are more efficient. We compare sample... Read More about Calculation of sample size for stroke trials assessing functional outcome: comparison of binary and ordinal approaches.

Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach (2008)
Journal Article

Background and Purpose: At least part of the failure in the transition from experimental to clinical studies in stroke has been attributed to the imprecision introduced by problems in the design of experimental stroke studies. Using a metaepidemiolog... Read More about Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach.

Stroke outcome in clinical trial patients deriving from different countries (2008)
Journal Article

Background and Purpose—Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations rem... Read More about Stroke outcome in clinical trial patients deriving from different countries.

Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials (2008)
Journal Article

Background and Purpose—An early and reliable prognosis for recovery in stroke patients is important for initiation of individual treatment and for informing patients and relatives. We recently developed and validated models for predicting survival a... Read More about Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials.

A randomised controlled trial of triple antiplatelet therapy (Aspirin, Clopidogrel and Dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility (2008)
Journal Article

Background: Aspirin, dipyridamole and clopidogrel are effective in secondary vascular prevention. Combination therapy with three antiplatelet agents might maximise the benefit of antiplatelet treatment in the secondary prevention of ischaemic stroke.... Read More about A randomised controlled trial of triple antiplatelet therapy (Aspirin, Clopidogrel and Dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility.

A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection (2008)
Journal Article

PURPOSE: Antimicrobial peptides (AMPs) are cationic host defense peptides with microbicidal and cell-signaling properties. They show promise as potential therapeutic agents. In the present study, a beta-defensin AMP gene was isolated from the ocular... Read More about A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection.