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A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others (2018)
Journal Article
Hall, D. A., Fackrell, K. L., Li, A. B., Thavayogan, R., Smith, S., Kennedy, V., …Haider, H. (2018). A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others. Health and Quality of Life Outcomes, 16, Article 61. https://doi.org/10.1186/s12955-018-0888-9

Background: There are a large number of assessment tools for tinnitus, with little consensus on what it is important to measure and no preference for a minimum reporting standard. The item content of tinnitus assessment tools should seek to capture r... Read More about A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others.

Femoral Nerve Block Intervention in Neck of Femur Fracture (FINOF): a randomized controlled trial (2018)
Journal Article
Rowlands, M., Walt, G. V. D., Bradley, J., Mannings, A., Armstrong, S., Bedforth, N. M., …Sahota, O. (2018). Femoral Nerve Block Intervention in Neck of Femur Fracture (FINOF): a randomized controlled trial. BMJ Open, 8(4), Article e019650. https://doi.org/10.1136/bmjopen-2017-019650

Objective Fractured neck of femur is a severely painful condition with significant mortality and morbidity. We investigated whether early and continuous use of femoral nerve block can improve pain on movement and mobility after surgery in older p... Read More about Femoral Nerve Block Intervention in Neck of Femur Fracture (FINOF): a randomized controlled trial.

Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited (2018)
Journal Article
Constantinescu, C. S., & Gershkovich, P. (2018). Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited. European Journal of Neurology, 25(7), 905-906. https://doi.org/10.1111/ene.13658

Cannabinoids are compounds with pleiotropic properties that act on the cannabinoid receptors, CB1 and CB2, and are divided into endocannabinoids, the endogenous ligands of these receptors, synthetic cannabinoids and phytocannabinoids. The latter are... Read More about Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited.

Probing the brain with molecular fMRI (2018)
Journal Article
Ghosh, S., Harvey, P., Simon, J. C., & Jasanoff, A. (2018). Probing the brain with molecular fMRI. Current Opinion in Neurobiology, 50, 201-210. https://doi.org/10.1016/j.conb.2018.03.009

© 2018 Elsevier Ltd One of the greatest challenges of modern neuroscience is to incorporate our growing knowledge of molecular and cellular-scale physiology into integrated, organismic-scale models of brain function in behavior and cognition. Molecul... Read More about Probing the brain with molecular fMRI.

Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different (2018)
Journal Article
Ross, A. R., Said, D. G., El-Amin, A., Altaan, S., Cabrerizo, J., Nubile, M., …Dua, H. S. (2018). Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different. British Journal of Ophthalmology, 102(12), 1646-1652. https://doi.org/10.1136/bjophthalmol-2017-311349

Aims: To investigate and define the nature of big bubbles (BB) formed by injection of viscoelastic in deep anterior lamellar keratoplasty. Methods: Intrastromal injections of 0.1 and 0.3 mL of sodium hyaluronate 1.2% and 0.6% were made into sclera... Read More about Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different.

Communication calls produced by electrical stimulation of four structures in the guinea pig brain (2018)
Journal Article
Green, D. B., Shackleton, T. M., Grimsley, J. M., Zobay, O., Wallace, M. N., & Palmer, A. R. (2018). Communication calls produced by electrical stimulation of four structures in the guinea pig brain. PLoS ONE, 13(3), Article e0194091. https://doi.org/10.1371/journal.pone.0194091

One of the main central processes affecting the cortical representation of conspecific vocalizations is the collateral output from the extended motor system for call generation. Before starting to study this interaction we sought to compare the chara... Read More about Communication calls produced by electrical stimulation of four structures in the guinea pig brain.

Development and validation of the Nottingham Auditory Milestones (NAMES) profile for deaf children under 2 years old, using cochlear implants (2018)
Journal Article
Datta, G., Kitterick, P. T., & Ramirez-Inscoe, J. (2018). Development and validation of the Nottingham Auditory Milestones (NAMES) profile for deaf children under 2 years old, using cochlear implants. Cochlear Implants International, 19(4), 181-192. https://doi.org/10.1080/14670100.2018.1452560

Objectives: Clinicians face considerable challenges in setting appropriate auditory goals for babies and young children who receive cochlear implants. This paper describes the rationale, organisation, implementation and validation of the Nottingham... Read More about Development and validation of the Nottingham Auditory Milestones (NAMES) profile for deaf children under 2 years old, using cochlear implants.

Anaesthesia workload measurement devices: qualitative systematic review (2018)
Journal Article
Almghairbi, D. S., Marufu, T. C., & Moppett, I. K. (2018). Anaesthesia workload measurement devices: qualitative systematic review. BMJ Simulation & Technology Enhanced Learning, 4(3), 112-116. https://doi.org/10.1136/bmjstel-2017-000263

Background: Management of mental workload is a key aspect of safety in anaesthesia but there is no gold standard tool to assess mental workload, risking confusion in clinical and research use of such tools. Objective: This review assessed currentl... Read More about Anaesthesia workload measurement devices: qualitative systematic review.

Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons (2018)
Journal Article
Geiszler, P. C., Ugun-Klusek, A., Lawler, K., Pardon, M., Yuchun, D., Bai, L., …Bedford, L. (in press). Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons. Scientific Reports, 8, Article 4833. https://doi.org/10.1038/s41598-018-23155-2

Metabolite profiling is an important tool that may better capture the multiple features of neurodegeneration. With the considerable parallels between mouse and human metabolism, the use of metabolomics in mouse models with neurodegenerative pathology... Read More about Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons.

Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis (2018)
Journal Article
Cottam, W. J., Iwabuchi, S. J., Drabek, M. M., Reckziegel, D., & Auer, D. P. (2018). Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis. PAIN, 159(5), https://doi.org/10.1097/j.pain.0000000000001209

Resting-state functional connectivity (FC) has proven a powerful approach to understand the neural underpinnings of chronic pain, reporting altered connectivity in three main networks: the default mode (DMN), central executive (CEN), and the salience... Read More about Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis.

Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology (2018)
Journal Article
Messina, M., & Dua, H. S. (2019). Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology. International Ophthalmology, 39(3), 693-696. https://doi.org/10.1007/s10792-018-0843-0

Purpose To evaluate the effect of once daily administration of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease (DED). Methods Eighteen patients (3 male, 15 female) aged 25–86 years (mean 61.1) and suffering from moder... Read More about Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology.

The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study (Preprint) (2018)
Other
Dewey, R. S., Hall, D. A., Guest, H., Prendergast, G., Plack, C. J., & Francis, S. T. (2018). The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study (Preprint)

Background: Rodent studies indicate that noise exposure can cause permanent damage to synapses between inner hair cells and high-threshold auditory nerve fibers, without permanently altering threshold sensitivity. These demonstrations of what is c... Read More about The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study (Preprint).

The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study (2018)
Journal Article
Dewey, R. S., Hall, D. A., Guest, H., Prendergast, G., Plack, C. J., & Francis, S. T. (2018). The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study. JMIR Research Protocols, 7(3), Article e79. https://doi.org/10.2196/resprot.9095

Background: Rodent studies indicate that noise exposure can cause permanent damage to synapses between inner hair cells and high-threshold auditory nerve fibers, without permanently altering threshold sensitivity. These demonstrations of what is comm... Read More about The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study.

Bayesian optimization of large-scale biophysical networks (2018)
Journal Article
Hadida, J., Sotiropoulos, S. N., Abeysuriya, R. G., Woolrich, M. W., & Jbabdi, S. (2018). Bayesian optimization of large-scale biophysical networks. NeuroImage, 174, https://doi.org/10.1016/j.neuroimage.2018.02.063

The relationship between structure and function in the human brain is well established, but not yet well characterised. Large-scale biophysical models allow us to investigate this relationship, by leveraging structural information (e.g. derived from... Read More about Bayesian optimization of large-scale biophysical networks.

The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial (2018)
Journal Article
Al-Shahi Salman, R., Dennis, M. S., Murray, G. D., Innes, K., Drever, J., Dinsmore, L., …Werring, D. J. (2018). The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial. Trials, 19(1), Article 162. https://doi.org/10.1186/s13063-018-2542-6

Background For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is... Read More about The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial.

Defining and evaluating novel procedures for involving patients in Core Outcome Set research: creating a meaningful long list of candidate outcome domains (2018)
Journal Article
Smith, H., Horobin, A. J., Fackrell, K., Colley, V., Thacker, B., & Hall, D. A. (2018). Defining and evaluating novel procedures for involving patients in Core Outcome Set research: creating a meaningful long list of candidate outcome domains. Research Involvement and Engagement, 4(8), https://doi.org/10.1186/s40900-018-0091-5

Background Tinnitus is a complex audiological condition affecting many different domains of everyday life. Clinical trials of tinnitus interventions measure and report those outcome domains inconsistently and this hinders direct comparison between s... Read More about Defining and evaluating novel procedures for involving patients in Core Outcome Set research: creating a meaningful long list of candidate outcome domains.

Interpreting the Tinnitus Questionnaire (German version):what individual differences are clinically important? (2018)
Journal Article
Hall, D. A., Mehta, R., & Argstatter, H. (2018). Interpreting the Tinnitus Questionnaire (German version):what individual differences are clinically important?. International Journal of Audiology, 57(7), 553-557. https://doi.org/10.1080/14992027.2018.1442591

Objective: Reporting of clinical significance is recommended because findings can be statistically significant without being relevant to patients. For aiding clinical interpretation of the Tinnitus Questionnaire (TQ), many investigators use a 5-point... Read More about Interpreting the Tinnitus Questionnaire (German version):what individual differences are clinically important?.

The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; peer review: 2 approved] (2018)
Journal Article
Ker, K., Prieto-Merino, D., Sprigg, N., Mahmood, A., Bath, P. M., Kang Law, Z., …Roberts, I. (2018). The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; peer review: 2 approved]. Wellcome Open Research, Article 120. https://doi.org/10.12688/wellcomeopenres.13262.2

© 2018 Ker K et al. Introduction: The Antifibrinolytic Trialists Collaboration aims to increase knowledge about the effectiveness and safety of antifibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials.... Read More about The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; peer review: 2 approved].