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Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer (2017)
Journal Article
Shafiee, M. N., Mongan, N. P., Seedhouse, C., Chapman, C., Deen, S., Abu, J., & Atiomo, W. (2017). Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer. Acta Obstetricia et Gynecologica Scandinavica, 96(5), 556-562. https://doi.org/10.1111/aogs.13106

Introduction: Women with polycystic ovary syndrome (PCOS) have a 3-fold higher risk of endometrial cancer (EC). Insulin resistance and hyperlipidaemia may be pertinent factors in the pathogenesis of both conditions. The aim of this study was to inves... Read More about Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer.

Heterozygous truncation mutations of the SMC1A gene cause a severe early onset epilepsy with cluster seizures in females: Detailed phenotyping of 10 new cases (2017)
Journal Article
Symonds, J. D., Joss, S., Metcalfe, K. A., Somarathi, S., Cruden, J., Devlin, A. M., Donaldson, A., DiDonato, N., Fitzpatrick, D., Kaiser, F. J., Lampe, A. K., Lees, M. M., McLellan, A., Montgomery, T., Mundada, V., Nairn, L., Sarkar, A., Schallner, J., Pozojevic, J., Parenti, I., …Zuberi, S. M. (2017). Heterozygous truncation mutations of the SMC1A gene cause a severe early onset epilepsy with cluster seizures in females: Detailed phenotyping of 10 new cases. Epilepsia, 58(4), 565-575. https://doi.org/10.1111/epi.13669

OBJECTIVE: The phenotype of seizure clustering with febrile illnesses in infancy/early childhood is well recognized. To date the only genetic epilepsy consistently associated with this phenotype is PCDH19, an X-linked disorder restricted to females,... Read More about Heterozygous truncation mutations of the SMC1A gene cause a severe early onset epilepsy with cluster seizures in females: Detailed phenotyping of 10 new cases.

The speed of increasing milk feeds: a randomised controlled trial (2017)
Journal Article
Abbott, J., Berrington, J., Bowler, U., Boyle, E., Dorling, J., Embleton, N., Juszczak, E., Leaf, A., Linsell, L., Johnson, S., McCormick, K., McGuire, W., Roberts, T., & Stenson, B. (in press). The speed of increasing milk feeds: a randomised controlled trial. BMC Pediatrics, 17(1), Article 39. https://doi.org/10.1186/s12887-017-0794-z

BACKGROUND

In the UK, 1-2% of infants are born very preterm (<32 weeks of gestation) or have very low birth weight (<1500 g). Very preterm infants are initially unable to be fed nutritional volumes of milk and therefore require intravenous nutriti...

Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo (2017)
Journal Article
Scotney, H., Symonds, M. E., Law, J., Budge, H., Sharkey, D., & Manolopoulos, K. N. (2017). Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo. Metabolism, 70, 125-132. https://doi.org/10.1016/j.metabol.2017.01.024

© 2017 The Authors Introduction Brown adipose tissue (BAT) is a thermogenic organ with substantial metabolic capacity and has important roles in the maintenance of body weight and metabolism. Regulation of BAT is primarily mediated through the β-adre... Read More about Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo.

Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer (2017)
Journal Article
Omran, Z., Scaife, P., Stewart, S., & Rauch, C. (2017). Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer. Seminars in Cancer Biology, 43, https://doi.org/10.1016/j.semcancer.2017.01.002

The role of the Warburg effect in cancer remains to be elucidated with a resurgence in research efforts over the past decade. Why a cancer cell would prefer to use energy inefficient glycolysis, leading to an alteration of pH both inside and outside... Read More about Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer.

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors (2016)
Journal Article
Torchia, J., Golbourn, B., Feng, S., Ching Ho, K., Sin-Chan, P., Vasiljevic, A., Norman, J. D., Guilhamon, P., Garzia, L., Agamez, N. R., Lu, M., Chan, T. S., Picard, D., de Antonellis, P., Khuong-Quang, D.-A., Planello, A. C., Zeller, C., Barsyte-Lovejoy, D., Lafay-Cousin, L., Letourneau, L., …Huang, A. (2016). Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors. Cancer Cell, 30(6), 891-908. https://doi.org/10.1016/j.ccell.2016.11.003

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we anal... Read More about Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? (2016)
Journal Article
Aldiss, P., Budge, H., & Symonds, M. E. (2016). Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause?. Cardiovascular Endocrinology, 5(4), 155-156. https://doi.org/10.1097/XCE.0000000000000089

Maintenance of thermal homeostasis within a tight range is regulated not only by a variety of internal and external cues but also by sex and biological age. The major organ responsible for adaptive thermogenesis is brown adipose tissue (BAT) and the... Read More about Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause?.

‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk (2016)
Journal Article
Aldiss, P., Davies, G., Woods, R., Budge, H., Sacks, H. S., & Symonds, M. E. (2017). ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk. International Journal of Cardiology, 228, https://doi.org/10.1016/j.ijcard.2016.11.074

Excess visceral adiposity, in particular that located adjacent to the heart and coronary arteries is associated with increased cardiovascular risk. In the pathophysiological state, dysfunctional adipose tissue secretes an array of factors modulating... Read More about ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk.

Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study (2016)
Journal Article
Barr, H. L., Halliday, N., Barrett, D. A., Williams, P., Forrester, D. L., Peckham, D., Williams, K., Smyth, A. R., Honeybourne, D., L. Whitehouse, J., Nash, E. F., Dewar, J., Clayton, A., Knox, A. J., Cámara, M., & Fogarty, A. W. (2017). Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study. Journal of Cystic Fibrosis, 16(2), 230-238. https://doi.org/10.1016/j.jcf.2016.10.005

Background
Pulmonary P. aeruginosa infection is associated with poor outcomes in cystic fibrosis (CF) and early diagnosis is challenging, particularly in those who are unable to expectorate sputum. Specific P. aeruginosa 2-alkyl-4-quinolones are det... Read More about Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study.

Random allocation of blastomere descendants to the trophectoderm and ICM of the bovine blastocyst (2016)
Journal Article
Sepulveda-Rincon, L. P., Dube, D., Adenot, P., Laffont, L., Ruffini, S., Gall, L., Campbell, B. K., Duranthon, V., Beaujean, N., & Maalouf, W. E. (2016). Random allocation of blastomere descendants to the trophectoderm and ICM of the bovine blastocyst. Biology of Reproduction, 95(6), 1-10. https://doi.org/10.1095/biolreprod.116.141200

The first lineage specification during mammalian embryo development can be visually distinguished at the blastocyst stage. Two cell lineages are observed on the embryonic-abembryonic axis of the blastocyst: the inner cell mass and the trophectoderm.... Read More about Random allocation of blastomere descendants to the trophectoderm and ICM of the bovine blastocyst.

Hepatic caveolin-1 is enhanced in Cyp27A1/ApoE double knockout mice (2016)
Journal Article
Zurkinden, L., Mansour, Y., Rohrbach, B., Vogt, B., Mistry, H. D., & Escher, G. (2016). Hepatic caveolin-1 is enhanced in Cyp27A1/ApoE double knockout mice. FEBS Open Bio, 6(10), https://doi.org/10.1002/2211-5463.12123

Sterol 27-hydroxylase (CYP27A1) is involved in bile acid synthesis and cholesterol homoeostasis. Cyp27a1(−/−)/Apolipoprotein E(−/−) double knockout mice (DKO) fed a western diet failed to develop atherosclerosis. Caveolin-1 (CAV-1), the main componen... Read More about Hepatic caveolin-1 is enhanced in Cyp27A1/ApoE double knockout mice.

Women's views and postpartum follow-up in the CHIPS Trial (Control of Hypertension in Pregnancy Study) (2016)
Journal Article
Vidler, M., Magee, L. A., von Dadelszen, P., Rey, E., Ross, S., Asztalos, E., Murphy, K. E., Menzies, J., Sanchez, J., Singer, J., Gafni, A., Gruslin, A., Helewa, M., Hutton, E., Lee, S. K., Lee, T., Logan, A. G., Ganzevoort, W., Welch, R., Thornton, J., & Moutquin, J.-M. (2016). Women's views and postpartum follow-up in the CHIPS Trial (Control of Hypertension in Pregnancy Study). European Journal of Obstetrics and Gynecology and Reproductive Biology, 206, 105-113. https://doi.org/10.1016/j.ejogrb.2016.07.509

Objective: To compare women’s views about blood pressure (BP) control in CHIPS (Control of
Hypertension In Pregnancy Study) (NCT01192412).
Design: Quantitative and qualitative analysis of questionnaire responses.
Setting: International randomised... Read More about Women's views and postpartum follow-up in the CHIPS Trial (Control of Hypertension in Pregnancy Study).

Circadian changes and sex-related differences in fetal heart rate parameters (2016)
Journal Article
Kapaya, H., Broughton Pipkin, F., Hayes-Gill, B., & Loughna, P. V. (2016). Circadian changes and sex-related differences in fetal heart rate parameters. Maternal Health, Neonatology and Perinatology, 2(1), https://doi.org/10.1186/s40748-016-0037-6

BACKGROUND: Previous researchers have studied circadian changes in the fetal heart rate (FHR) on small sample sizes and in a strictly controlled environment. This study was undertaken to investigate these changes during the late second and third trim... Read More about Circadian changes and sex-related differences in fetal heart rate parameters.

Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF (2016)
Journal Article
Massey, A., Campbell, B. K., Raine-Fenning, N., Pincott-Allen, C., Perry, J., & Vedhara, K. (2016). Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF. Psychoneuroendocrinology, 74, https://doi.org/10.1016/j.psyneuen.2016.08.027

Evidence for an association between cortisol and clinical pregnancy in women undergoing In Vitro Fertilisation (IVF) is mixed with previous studies relying exclusively on short term measures of cortisol in blood, saliva, urine, and/or follicular flui... Read More about Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF.

Adipocyte browning and higher mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma (2016)
Journal Article
Vergnes, L., Davies, G. R., Lin, J. Y., Yeh, M. W., Livhits, M. J., Harari, A., Symonds, M. E., Sacks, H. S., & Reue, K. (2016). Adipocyte browning and higher mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma. Journal of Clinical Endocrinology and Metabolism, 101(11), https://doi.org/10.1210/jc.2016-2670

Context:

Patients with pheochromocytoma (pheo) show presence of multilocular adipocytes that express uncoupling protein (UCP) 1 within periadrenal (pADR) and omental (OME) fat depots. It has been hypothesized that this is due to adrenergic stimula... Read More about Adipocyte browning and higher mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma.

Growth and nutrition in children with Ataxia telangiectasia (2016)
Journal Article
Stewart, E., Prayle, A. P., Tooke, A., Pasalodos, S., Suri, M., Bush, A., & Bhatt, J. (in press). Growth and nutrition in children with Ataxia telangiectasia. Archives of Disease in Childhood, 101(12), https://doi.org/10.1136/archdischild-2015-310373

Background: Ataxia telangiectasia (A-T) is a rare multisystem disease with high early mortality from lung disease and cancer. Nutritional failure adversely impacts outcomes in many respiratory diseases. Several factors influence nutrition in children... Read More about Growth and nutrition in children with Ataxia telangiectasia.

The cost implications of less tight versus tight Control of Hypertension in Pregnancy (CHIPS Trial)novelty and significance (2016)
Journal Article
Ahmed, R. J., Gafni, A., Hutton, E. K., Hu, Z. J., Pullenayegum, E., von Dadelszen, P., Rey, E., Ross, S., Asztalos, E., Murphy, K. E., Menzies, J., Sanchez, J. J., Ganzevoort, W., Helewa, M., Lee, S. K., Lee, T., Logan, A. G., Moutquin, J.-M., Singer, J., Thornton, J., …Magee, L. A. (2016). The cost implications of less tight versus tight Control of Hypertension in Pregnancy (CHIPS Trial)novelty and significance. Hypertension, 68(4), 1049-1055. https://doi.org/10.1161/HYPERTENSIONAHA.116.07466

The CHIPS randomized controlled trial (Control of Hypertension in Pregnancy Study) found no difference in the primary perinatal or secondary maternal outcomes between planned “less tight” (target diastolic 100 mm Hg) and “tight” (target diastolic 85... Read More about The cost implications of less tight versus tight Control of Hypertension in Pregnancy (CHIPS Trial)novelty and significance.

Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database (2016)
Journal Article
Maalouf, W. E., Maalouf, W., Campbell, B., & Jayaprakasan, K. (in press). Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database. BJOG: An International Journal of Obstetrics and Gynaecology, https://doi.org/10.1111/1471-0528.14241

Objective

To evaluate the effect of ethnicity of women on the outcome of in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) treatment.

Design

Observational cohort study.

Setting

UK National Database.

Population... Read More about Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database.

Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma (2016)
Journal Article
Linke, F., Harenberg, M., Nietert, M. M., Zaunig, S., von Bonin, F., Arlt, A., Szczepanowski, M., Weich, H. A., Lutz, S., Dullin, C., Janovská, P., Krafčíková, M., Trantírek, L., Ovesná, P., Klapper, W., Beissbarth, T., Alves, F., Bryja, V., Trümper, L., Wilting, J., & Kube, D. (2017). Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. Leukemia, 31(2), 361-372. https://doi.org/10.1038/leu.2016.232

The interaction between vascular endothelial cells (ECs) and cancer cells is of vital importance to understand tumor dissemination. A paradigmatic cancer to study cell–cell interactions is classical Hodgkin Lymphoma (cHL) owing to its complex microen... Read More about Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma.