All Outputs (488)

AMP-Activated Protein Kinase: Friend or Foe in Cancer? (2019)
Journal Article
Vara-Ciruelos, D., Dandapani, M., & Hardie, D. G. (2020). AMP-Activated Protein Kinase: Friend or Foe in Cancer?. Annual Review of Cancer Biology, 4(1), 1-16. https://doi.org/10.1146/annurev-cancerbio-030419-033619

The AMP-activated protein kinase (AMPK) is activated by energy stress and restores homeostasis by switching on catabolism, while switching off cell growth and proliferation. Findings that AMPK acts downstream of the tumor suppressor LKB1 have suggest... Read More about AMP-Activated Protein Kinase: Friend or Foe in Cancer?.

Bio-electrosprayed human sperm remain viable (2019)
Journal Article
O'Neill, H. C., Maalouf, W. E., Harper, J. C., & Jayasinghe, S. N. (2019). Bio-electrosprayed human sperm remain viable. Materials Today, 31, 21-30. https://doi.org/10.1016/j.mattod.2019.10.004

© 2019 Elsevier Ltd In our previous investigations, we demonstrated that certain living cells exposed to bio-electrosprays remained viable, and behaved as expected in comparison to control cells. These studies also extended to post-bio-electrosprayed... Read More about Bio-electrosprayed human sperm remain viable.

Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis (2019)
Journal Article
Webb, K., Fogarty, A., Barrett, D. A., Nash, E. F., Whitehouse, J. L., Smyth, A. R., Stewart, I., Knox, A., Williams, P., Halliday, N., Barr, H. L., & Cámara, M. (2019). Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis. Journal of Medical Microbiology, 68(12), 1823-1828. https://doi.org/10.1099/jmm.0.001099

Introduction : Pseudomonas aeruginosa is an important respiratory pathogen in cystic fibrosis (CF), which is associated with an accelerated decline in lung function, frequent pulmonary exacerbations and increased mortality. P. aeruginosa produces in... Read More about Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis.

Investigating ataxia in childhood (2019)
Journal Article
Petley, E., Prasad, M., Ojha, S., & Whitehouse, W. P. (2019). Investigating ataxia in childhood. Archives of Disease in Childhood.education and Practice Edition, https://doi.org/10.1136/archdischild-2018-315893

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. Ataxia is a common presentation to an acute paediatric unit and it can often be difficult to determine the cause. It is important to distingu... Read More about Investigating ataxia in childhood.

Paternal diet impairs F1 and F2 offspring vascular function through sperm and seminal plasma specific mechanisms in mice (2019)
Journal Article
Morgan, H. L., Paganopoulou, P., Akhtar, S., Urquhart, N., Philomin, R., Dickinson, Y., & Watkins, A. J. (2020). Paternal diet impairs F1 and F2 offspring vascular function through sperm and seminal plasma specific mechanisms in mice. Journal of Physiology, 598(4), 699-715. https://doi.org/10.1113/jp278270

Although the impact of maternal diet on adult offspring health is well characterized, the role that a father's diet has on his offspring's health remains poorly defined. We establish the significance of a sup-optimal paternal low protein diet for off... Read More about Paternal diet impairs F1 and F2 offspring vascular function through sperm and seminal plasma specific mechanisms in mice.

In search of effective therapies to overcome resistance to Temozolomide in brain tumours (2019)
Journal Article
Grundy, R., Bouzinab, K., Summers, H., Zhang, J., Stevens, M. F. G., Moody, C. J., Turyanska, L., Thomas, N. R., Gershkovich, P., Ashford, M. B., Vitterso, E., Storer, L. C. D., & Bradshaw, T. D. (2019). In search of effective therapies to overcome resistance to Temozolomide in brain tumours. Cancer Drug Resistance, 2(4), 1018-1031. https://doi.org/10.20517/cdr.2019.64

Glioblastoma multiforme is the most common and lethal brain tumour-type. The current standard of care includes Temozolomide (TMZ) chemotherapy. However, inherent and acquired resistance to TMZ thwart successful treatment. The direct repair protein me... Read More about In search of effective therapies to overcome resistance to Temozolomide in brain tumours.

Rojiroti microfinance and child nutrition: a cluster randomised trial (2019)
Journal Article
Ojha, S., Szatkowski, L., Sinha, R., Yaron, G., Fogarty, A., Allen, S., Choudhary, S., & Smyth, A. R. (2020). Rojiroti microfinance and child nutrition: a cluster randomised trial. Archives of Disease in Childhood, 105(3), 229-235. https://doi.org/10.1136/archdischild-2018-316471

Objective To determine whether Rojiroti microfinance, for poor Indian women, improves child nutrition.

Design Cluster randomised trial.

Setting Tolas (village communities) in Bihar State.

Participants Women and children under 5 years.

Int... Read More about Rojiroti microfinance and child nutrition: a cluster randomised trial.

Using digital technology for home monitoring, adherence and self-management in cystic fibrosis: A state of the art review (2019)
Journal Article
Calthorpe, R. J., Smith, S., Gathercole, K., & Smyth, A. R. (2020). Using digital technology for home monitoring, adherence and self-management in cystic fibrosis: A state of the art review. Thorax, 75(1), 72-77. https://doi.org/10.1136/thoraxjnl-2019-213233

Digital healthcare is a rapidly growing healthcare sector. Its importance has been recognised at both national and international level, with the WHO recently publishing its first global strategy for digital health. The use of digital technology withi... Read More about Using digital technology for home monitoring, adherence and self-management in cystic fibrosis: A state of the art review.

Childbirth experience questionnaire 2: Validating its use in the United Kingdom (2019)
Journal Article
Walker, K. F., Dencker, A., & Thornton, J. G. (2020). Childbirth experience questionnaire 2: Validating its use in the United Kingdom. European Journal of Obstetrics && Gynecology and Reproductive Biology: X, 5, Article 100097. https://doi.org/10.1016/j.eurox.2019.100097

© 2019 The Authors Objective: To validate the Childbirth Experience Questionnaire 2 (CEQ2) in the UK to see if it is an effective tool for evaluating labour experience. Study design: The CEQ2 and part of the Care Quality Commission Maternity Survey (... Read More about Childbirth experience questionnaire 2: Validating its use in the United Kingdom.

Bovine sperm defects are affected by breed, age, season and region (2019)
Journal Article
Felton-Taylor, J., Prosser, K. A., Hernandez-Medrano, J. H., Gentili, S., Copping, K. J., Macrossan, P. E., & Perry, V. E. (2020). Bovine sperm defects are affected by breed, age, season and region. Theriogenology, 142, 1-7. https://doi.org/10.1016/j.theriogenology.2019.09.001

This study reports the distribution of sperm morphology defects by breed, age, season and region of 11,387 bulls in 500 herds in Australia and near Pacific Islands during annual BBSE. Bull location was divided into 4 broad climatic regions based upon... Read More about Bovine sperm defects are affected by breed, age, season and region.

Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial (2019)
Journal Article
Chappell, L. C., Brocklehurst, P., Green, M. E., Hunter, R., Hardy, P., Juszczak, E., Linsell, L., Chiocchia, V., Greenland, M., Placzek, A., Townend, J., Marlow, N., Sandall, J., Shennan, A., Agarwal, U., Ahmed, I., Ajay, B., Alfirevic, Z., Arya, R., Bambridge, G., …Wu, P. (2019). Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial. Lancet, 394(10204), 1181-1190. https://doi.org/10.1016/s0140-6736%2819%2931963-4

© 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: In women with late preterm pre-eclampsia, the optimal time to initiate delivery is unclear because limitation of maternal disease... Read More about Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial.

Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial (2019)
Journal Article
Chappell, L. C., Bell, J. L., Smith, A., Linsell, L., Juszczak, E., Dixon, P. H., Chambers, J., Hunter, R., Dorling, J., Williamson, C., Thornton, J. G., Ahmed, I., Arya, R., Beckett, V., Bhide, A., Brown, H., Bugg, G., Cameron, H., Deole, N., Dey, M., …Tan, B. (2019). Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. Lancet, 394(10201), 849-860. https://doi.org/10.1016/s0140-6736%2819%2931270-x

A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma (2019)
Journal Article
Sabnis, D. H., Storer, L. C. D., Liu, J.-F., Jackson, H. K., Kilday, J. P., Grundy, R. G., Kerr, I. D., & Coyle, B. (2019). A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma. Scientific Reports, 9(1), 1-9. https://doi.org/10.1038/s41598-019-46700-z

© 2019, The Author(s). Three of the hallmarks of poor prognosis in paediatric ependymoma are drug resistance, local invasion and recurrence. We hypothesised that these hallmarks were due to the presence of a sub-population of cancer stem cells expres... Read More about A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma.

Live Simultaneous Monitoring of Mineral Deposition and Lipid Accumulation in Differentiating Stem Cells (2019)
Journal Article
De Melo, N., McGinlay, S., Markus, R., Macri-Pellizzeri, L., Symonds, M. E., Ahmed, I., & Sottile, V. (2019). Live Simultaneous Monitoring of Mineral Deposition and Lipid Accumulation in Differentiating Stem Cells. Biomimetics, 4(3), 1-10. https://doi.org/10.3390/biomimetics4030048

Mesenchymal stem cells (MSCs) are progenitors for bone-forming osteoblasts and lipid-storing adipocytes, two major lineages co-existing in bone marrow. When isolated in vitro, these stem cells recapitulate osteoblast or adipocyte formation if treated... Read More about Live Simultaneous Monitoring of Mineral Deposition and Lipid Accumulation in Differentiating Stem Cells.

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor (2019)
Journal Article
Sin-Chan, P., Mumal, I., Suwal, T., Ho, B., Fan, X., Singh, I., Du, Y., Lu, M., Patel, N., Torchia, J., Popovski, D., Fouladi, M., Guilhamon, P., Hansford, J. R., Leary, S., Hoffman, L. M., Mulcahy Levy, J. M., Lassaletta, A., Solano-Paez, P., Rivas, E., …Huang, A. (2019). A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor. Cancer Cell, 36(1), 51-67.e7. https://doi.org/10.1016/j.ccell.2019.06.002

© 2019 Elsevier Inc. Embryonal tumors with multilayered rosettes (ETMRs) are highly lethal infant brain cancers with characteristic amplification of Chr19q13.41 miRNA cluster (C19MC) and enrichment of pluripotency factor LIN28A. Here we investigated... Read More about A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

The influence of seminal plasma on offspring development and health (2019)
Journal Article
Morgan, H. L., & Watkins, A. J. (2020). The influence of seminal plasma on offspring development and health. Seminars in Cell and Developmental Biology, 97, 131-137. https://doi.org/10.1016/j.semcdb.2019.06.008

The concept that a father’s wellbeing at the time of conception influences the development and long-term health of his offspring is now well established. However, the mechanisms underlying the paternal programming of offspring health are not fully de... Read More about The influence of seminal plasma on offspring development and health.

Improved cryopreservation of spermatozoa using vitrification: comparison of cryoprotectants and a novel device for long-term storage (2019)
Journal Article
O’Neill, H. C., Nikoloska, M., Ho, H., Doshi, A., & Maalouf, W. (2019). Improved cryopreservation of spermatozoa using vitrification: comparison of cryoprotectants and a novel device for long-term storage. Journal of Assisted Reproduction and Genetics, 36(8), 1-8. https://doi.org/10.1007/s10815-019-01505-x

Study question
Does cryoprotection of spermatozoa using a vitrification protocol with improved cryoprotective agents and a novel device for large storage lead to better outcomes than conventional slow freezing?

Summary answer
Vitrification of hu... Read More about Improved cryopreservation of spermatozoa using vitrification: comparison of cryoprotectants and a novel device for long-term storage.

Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications (2019)
Journal Article
Mistry, H. D., Kurlak, L. O., Gardner, D. S., Torffvit, O., Hansen, A., Broughton Pipkin, F., & Strevens, H. (2019). Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications. Journal of the American Heart Association, 8(13), 1-11. https://doi.org/10.1161/JAHA.119.012611

Background-—AGT (angiotensinogen) synthesis occurs in renal proximal tubular epithelial cells, independent from systemic AGT, as a component of the intrarenal renin–angiotensin system. We investigated urinary AGT, as a biomarker for renin–angiotensin... Read More about Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications.

Advanced maternal age (2019)
Journal Article
Walker, K. F., & Thornton, J. G. (2019). Advanced maternal age. Obstetrics, Gynaecology and Reproductive Medicine, 29(9), 259-263. https://doi.org/10.1016/j.ogrm.2019.06.001

The average age of women at childbirth in industrialised nations has been increasing steadily for approximately 30 years. Women aged 35 years or over have an increased risk of gestational hypertensive disease, gestational diabetes, placenta praevia,... Read More about Advanced maternal age.

Caffeine exposure induces browning features in adipose tissue in vitro and in vivo (2019)
Journal Article
Velickovic, K., Wayne, D., Lugo Leija, H. A., Bloor, I., Morris, D. E., Law, J., Budge, H., Sacks, H., Symonds, M. E., & Sottile, V. (2019). Caffeine exposure induces browning features in adipose tissue in vitro and in vivo. Scientific Reports, 9(1), Article 9104. https://doi.org/10.1038/s41598-019-45540-1

Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1). Diet can modulate UCP1 function but the capacity of individual nut... Read More about Caffeine exposure induces browning features in adipose tissue in vitro and in vivo.