All Outputs (463)

Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial (2020)
Journal Article
Fleminger, J., Seed, P., Smith, A., Dixon, P., Juszczak, E., Chambers, J., …Chappell, L. (2021). Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial. BJOG: An International Journal of Obstetrics and Gynaecology, 128(6), 1066-1075. https://doi.org/10.1111/1471-0528.16567

Objective: To evaluate whether a particular group of women with intrahepatic cholestasis of pregnancy (ICP), based on their presenting characteristics, would benefit from treatment with ursodeoxycholic acid (UDCA). Design: Secondary analysis of the P... Read More about Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial.

TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML (2020)
Journal Article
Vadakekolathu, J., Lai, C., Reeder, S., Church, S. E., Hood, T., Lourdusamy, A., …Rutella, S. (2020). TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML. Blood Advances, 4(20), 5011-5024. https://doi.org/10.1182/bloodadvances.2020002512

Somatic TP53 mutations and 17p deletions with genomic loss of TP53 occur in 37% to 46% of acute myeloid leukemia (AML) with adverse-risk cytogenetics and correlate with primary induction failure, high risk of relapse, and dismal prognosis. Herein, we... Read More about TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML.

Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours (2020)
Journal Article
McCrorie, P., Mistry, J., Taresco, V., Lovato, T., Fay, M., Ward, I., …Rahman, R. (2020). Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours. European Journal of Pharmaceutics and Biopharmaceutics, 157, 108-120. https://doi.org/10.1016/j.ejpb.2020.10.005

Glioblastoma is a malignant brain tumour with a median survival of 14.6 months from diagnosis. Despite maximal surgical resection and concurrent chemoradiotherapy, reoccurrence is inevitable. To try combating the disease at a stage of low residual tu... Read More about Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours.

Universal third-trimester ultrasonic screening using fetal macrosomia in the prediction of adverse perinatal outcome: A systematic review and meta-analysis of diagnostic test accuracy (2020)
Journal Article
Moraitis, A. A., Shreeve, N., Sovio, U., Brocklehurst, P., Heazell, A. E. P., Thornton, J. G., …Smith, G. C. (2020). Universal third-trimester ultrasonic screening using fetal macrosomia in the prediction of adverse perinatal outcome: A systematic review and meta-analysis of diagnostic test accuracy. PLoS Medicine, 17(10), Article e1003190. https://doi.org/10.1371/journal.pmed.1003190

Background The effectiveness of screening for macrosomia is not well established. One of the critical elements of an effective screening program is the diagnostic accuracy of a test at predicting the condition. The objective of this study is to inve... Read More about Universal third-trimester ultrasonic screening using fetal macrosomia in the prediction of adverse perinatal outcome: A systematic review and meta-analysis of diagnostic test accuracy.

The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring (2020)
Journal Article
Aljahdali, A., Airina, R. K. R. I., Velazquez, M. A., Sheth, B., Wallen, K., Osmond, C., …Fleming, T. P. (2020). The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring. Human Reproduction, 35(11), 2497–2514. https://doi.org/10.1093/humrep/deaa205

Study question: Do the long-term health outcomes following IVF differ depending upon the duration of embryo culture before transfer? Summary answer: Using a mouse model, we demonstrate that in male but not female offspring, adverse cardiovascular... Read More about The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring.

Targeting glutamine synthesis inhibits stem cell adipogenesis in vitro (2020)
Journal Article
Velickovic, K., Lugo Leija, H. A., Surrat, A., Kim, D., Sacks, H., Symonds, M. E., & Sottile, V. (2020). Targeting glutamine synthesis inhibits stem cell adipogenesis in vitro. Cellular Physiology and Biochemistry, 54(5), 917-927. https://doi.org/10.33594/000000278

Background/Aims: Glutamine is the most abundant amino acid in the body and has a metabolic role as a precursor for protein, amino sugar and nucleotide synthesis. After glucose, glutamine is the main source of energy in cells and has recently been sho... Read More about Targeting glutamine synthesis inhibits stem cell adipogenesis in vitro.

Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia (2020)
Journal Article
Lugo Leija, H. A., Velickovic, K., Bloor, I., Sacks, H., Symonds, M. E., & Sottile, V. (2020). Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia. Journal of Cellular and Molecular Medicine, 24(19), 11434-11444. https://doi.org/10.1111/jcmm.15749

Beige adipocytes possess the morphological and biochemical characteristics of brown adipocytes, including the mitochondrial uncoupling protein (UCP)1. Mesenchymal stem cells (MSCs) are somatic multipotent progenitors which differentiate into lipid-la... Read More about Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia.

How can we relieve gastrointestinal symptoms in people with cystic fibrosis? An international qualitative survey (2020)
Journal Article
Smith, S., Rowbotham, N., Davies, G., Gathercole, K., Collins, S. J., Elliott, Z., …Smyth, A. (2020). How can we relieve gastrointestinal symptoms in people with cystic fibrosis? An international qualitative survey. BMJ Open Respiratory Research, 7(1), Article e000614. https://doi.org/10.1136/bmjresp-2020-000614

Introduction Relieving gastrointestinal (GI) symptoms was identified as a ‘top ten’ priority by our James Lind Alliance Priority Setting Partnership in cystic fibrosis (CF). We conducted an online survey to find out more about the effect of GI sympto... Read More about How can we relieve gastrointestinal symptoms in people with cystic fibrosis? An international qualitative survey.

Treatment of pulmonary exacerbations in cystic fibrosis (2020)
Journal Article
Ng, C., Nadig, T., Smyth, A. R., & Flume, P. (2020). Treatment of pulmonary exacerbations in cystic fibrosis. Current Opinion in Pulmonary Medicine, 26(6), 679-684. https://doi.org/10.1097/mcp.0000000000000730

Purpose of review This review will discuss the challenges of defining a pulmonary exacerbations in cystic fibrosis and the key pathogens, which contribute. It will discuss the treatment options currently available and the importance of preventing... Read More about Treatment of pulmonary exacerbations in cystic fibrosis.

International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019 (2020)
Journal Article
Evangelidis, N., Tong, A., Howell, M., Teixeira-Pinto, A., Elliott, J. H., Azevedo, L. C., …Craig, J. C. (2020). International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019. Critical Care Medicine, 48(11), 1612-1621. https://doi.org/10.1097/ccm.0000000000004584

Objectives: There are over 4,000 trials conducted in people with coronavirus disease 2019. However, the variability of outcomes and the omission of patient-centered outcomes may diminish the impact of these trials on decision-making. The aim of th... Read More about International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019.

Core Outcomes Set for Trials in People With Coronavirus Disease 2019 (2020)
Journal Article
Tong, A., Elliott, J. H., Azevedo, L. C., Baumgart, A., Bersten, A., Cervantes, L., …COVID-19-Core Outcomes Set (COS) Workshop Investigators. (2020). Core Outcomes Set for Trials in People With Coronavirus Disease 2019. Critical Care Medicine, 48(11), 1622-1635. https://doi.org/10.1097/ccm.0000000000004585

Objectives: The outcomes reported in trials in coronavirus disease 2019 are extremely heterogeneous and of uncertain patient relevance, limiting their applicability for clinical decision-making. The aim of this workshop was to establish a core outc... Read More about Core Outcomes Set for Trials in People With Coronavirus Disease 2019.

Impact of COVID-19 Pandemic on Surgical Neuro-oncology Multi-Disciplinary Team Decision Making – A National Survey (COVID-CNSMDT Study) (2020)
Journal Article
Price, S. J., Joannides, A. J., Plaha, P., Afshari, F. T., Albanese, E., Barua, N. U., …Jenkinson, M. D. (2020). Impact of COVID-19 Pandemic on Surgical Neuro-oncology Multi-Disciplinary Team Decision Making – A National Survey (COVID-CNSMDT Study). BMJ Open, 10(8), Article e040898. https://doi.org/10.1136/bmjopen-2020-040898

Objectives Pressures on healthcare systems due to COVID-19 has impacted patients without COVID-19 with surgery disproportionally affected. This study aims to understand the impact on the initial management of patients with brain tumours by measuring... Read More about Impact of COVID-19 Pandemic on Surgical Neuro-oncology Multi-Disciplinary Team Decision Making – A National Survey (COVID-CNSMDT Study).

What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment? (2020)
Journal Article
Calthorpe, R. J., Smith, S. J., Rowbotham, N. J., Leighton, P. A., Davies, G., Daniels, T., …Smyth, A. R. (2020). What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment?. BMJ Open Respiratory Research, 7(1), Article e000601. https://doi.org/10.1136/bmjresp-2020-000601

Introduction: “What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment?” was identified as one of the James Lind Alliance Priority Setting Partnership’s top 10 research q... Read More about What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment?.

Education of family members to support weaning to solids and nutrition in later infancy in term-born infants (2020)
Journal Article
Ojha, S., Elfzzani, Z., Kwok, T. C., & Dorling, J. (2020). Education of family members to support weaning to solids and nutrition in later infancy in term-born infants. Cochrane Database of Systematic Reviews, 2020(7), https://doi.org/10.1002/14651858.cd012241.pub2

Review question We reviewed the evidence for effects of nutrition education about appropriate feeding practices during weaning on growth and development in children born at term gestation. Background Around the world, over 150 million childr... Read More about Education of family members to support weaning to solids and nutrition in later infancy in term-born infants.

Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study (2020)
Journal Article
Safavi, S., Arthofer, C., Cooper, A., Harkin, J. W., Prayle, A. P., Sovani, M. P., …Hall, I. P. (2020). Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study. European Journal of Radiology, 130, Article 109196. https://doi.org/10.1016/j.ejrad.2020.109196

Purpose The diaphragm is the most important muscle of respiration. Disorders of the diaphragm can have a deleterious impact on respiratory function. We aimed to evaluate the use of an open-configuration upright low-field MRI system to assess diaphra... Read More about Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study.

Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations (2020)
Journal Article
Morris, B., Curtin, L., Hawkins-Daarud, A., Hubbard, M. E., Rahman, R., Smith, S. J., …Owen, M. R. (2020). Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations. Mathematical Biosciences and Engineering, 17(5), 4905-4941. https://doi.org/10.3934/mbe.2020267

Glioblastomas (GBMs) are the most aggressive primary brain tumours and have no known cure. Each individual tumour comprises multiple sub-populations of genetically-distinct cells that may respond differently to targeted therapies and may contribute t... Read More about Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations.

Extraction of Lipids from Liquid Biological Samples for High-Throughput Lipidomics (2020)
Journal Article
Furse, S., Watkins, A. J., & Koulman, A. (2020). Extraction of Lipids from Liquid Biological Samples for High-Throughput Lipidomics. Molecules, 25(14), https://doi.org/10.3390/molecules25143192

Extraction of the lipid fraction is a key part of acquiring lipidomics data. High-throughput lipidomics, the extraction of samples in 96w plates that are then run on 96 or 384w plates, has particular requirements that mean special development work is... Read More about Extraction of Lipids from Liquid Biological Samples for High-Throughput Lipidomics.

Metabolism based isolation of invasive glioblastoma cells with specific gene signatures and tumorigenic potential (2020)
Journal Article
Smith, S. J., Rowlinson, J., Estevez-Cebrero, M., Onion, D., Ritchie, A., Clarke, P., …Rahman, R. (2020). Metabolism based isolation of invasive glioblastoma cells with specific gene signatures and tumorigenic potential. Neuro-Oncology Advances, 2(1), Article vdaa087. https://doi.org/10.1093/noajnl/vdaa087

Background Glioblastoma (GBM) is a highly aggressive brain tumor with rapid subclonal diversification, harboring molecular abnormalities that vary temporo-spatially, a contributor to therapy resistance. Fluorescence guided neurosurgical resection ut... Read More about Metabolism based isolation of invasive glioblastoma cells with specific gene signatures and tumorigenic potential.

NF1 optic pathway glioma. Analysing risk factors for visual outcome and indications to treat (2020)
Journal Article
Azizi, A. A., Walker, D. A., Liu, J., Sehested, A., Jaspan, T., Pemp, B., …Opocher, E. (2021). NF1 optic pathway glioma. Analysing risk factors for visual outcome and indications to treat. Neuro-Oncology, 23(1), 100-111. https://doi.org/10.1093/neuonc/noaa153

Background The aim of the project was to identify risk factors associated with visual progression and treatment indications in pediatric patients with Neurofibromatosis type 1 associated optic pathway gliomas (NF1-OPG). Methods A multi-disciplin... Read More about NF1 optic pathway glioma. Analysing risk factors for visual outcome and indications to treat.

A retrospective analysis of recurrent pediatric ependymoma reveals extremely poor survival and ineffectiveness of current treatments across central nervous system locations and molecular subgroups (2020)
Journal Article
Ritzmann, T. A., Rogers, H. A., Paine, S. M., Storer, L. C., Jacques, T. S., Chapman, R. J., …Grundy, R. G. (2020). A retrospective analysis of recurrent pediatric ependymoma reveals extremely poor survival and ineffectiveness of current treatments across central nervous system locations and molecular subgroups. Pediatric Blood and Cancer, 67(9), Article e28426. https://doi.org/10.1002/pbc.28426

Background: Relapse occurs in 50% of pediatric ependymoma cases and has poor prognosis. Few studies have investigated the clinical progress of relapsed disease, and treatment lacks a standardized approach. Methods and materials: We analyzed 302 pedia... Read More about A retrospective analysis of recurrent pediatric ependymoma reveals extremely poor survival and ineffectiveness of current treatments across central nervous system locations and molecular subgroups.