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All Outputs (145)

The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis (2017)
Journal Article
Morandi, E., Tanasescu, R., Tarlinton, R. E., Constantinescu, C. S., Zhang, W., Tench, C. R., & Gran, B. (2017). The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis. PLoS ONE, 12(2), Article e0172415. https://doi.org/10.1371/journal.pone.0172415

Background: The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS.... Read More about The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis.

Using an integrative, Cognitive Analytical Therapy (CAT) approach to treat intimate partner violence risk (2017)
Journal Article
Tully, R., & Barrow, A. (in press). Using an integrative, Cognitive Analytical Therapy (CAT) approach to treat intimate partner violence risk. Journal of Aggression, Conflict and Peace Research, 9(2), https://doi.org/10.1108/JACPR-08-2016-0244

Aims: There is limited research on Cognitive Analytic Therapy (CAT) in forensic contexts; this case study therefore significantly contributes to the knowledge base. This case study presents the assessment and treatment of an adult male offender with... Read More about Using an integrative, Cognitive Analytical Therapy (CAT) approach to treat intimate partner violence risk.

Medulloblastoma and ependymoma cells display levels of 5-carboxylcytosine and elevated TET1 expression (2017)
Journal Article
Ramsawhook, A., Lewis, L., Coyle, B., & Ruzov, A. (2017). Medulloblastoma and ependymoma cells display levels of 5-carboxylcytosine and elevated TET1 expression. Clinical Epigenetics, 9(18), https://doi.org/10.1186/s13148-016-0306-2

Background Alteration of DNA methylation (5-methylcytosine, 5mC) patterns represents one of the causes of tumorigenesis and cancer progression. Tet proteins can oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine and 5-carboxylcytosine (... Read More about Medulloblastoma and ependymoma cells display levels of 5-carboxylcytosine and elevated TET1 expression.

Different measures of auditory and visual stroop interference and their relationship to speech intelligibility in noise (2017)
Journal Article
Knight, S., & Heinrich, A. (in press). Different measures of auditory and visual stroop interference and their relationship to speech intelligibility in noise. Frontiers in Psychology, 8, https://doi.org/10.3389/fpsyg.2017.00230

Inhibition – the ability to suppress goal-irrelevant information – is thought to be an important cognitive skill in many situations, including speech-in-noise (SiN) perception. One way to measure inhibition is by means of Stroop tasks, in which one s... Read More about Different measures of auditory and visual stroop interference and their relationship to speech intelligibility in noise.

The effective ingredients of social care support at home for people with dementia: a literature review (2017)
Journal Article
Argyle, E., Kelly, T., Gladman, J. R., & Jones, R. (2017). The effective ingredients of social care support at home for people with dementia: a literature review. Journal of Integrated Care, 25(2), 110-119. https://doi.org/10.1108/JICA-09-2016-0032

Purpose: Formal ties between the theatre and research dissemination have only recently developed and its general efficacy is largely unknown. Here the purpose of this paper is to redress this neglect by examining the effectiveness of a research-base... Read More about The effective ingredients of social care support at home for people with dementia: a literature review.

Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study (2017)
Journal Article
Kuo, C. F., Grainge, M. J., Valdes, A. M., See, L. C., Yu, K. H., Steven Shaw, S. W., …Doherty, M. (2017). Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study. Rheumatology, 56(6), 928-933. https://doi.org/10.1093/rheumatology/kew500

© The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. Objective. The aim was to estimate familial relative risk (RR) for RA and other autoimmune diseases and the genetic contri... Read More about Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study.

Investigating the effect of independent blinded digital image assessment on the STOP GAP trial (2017)
Journal Article
Patsko, E., Godolphin, P. J., Thomas, K. S., Hepburn, T., Mitchell, E., Craig, F. E., …Montgomery, A. A. (2017). Investigating the effect of independent blinded digital image assessment on the STOP GAP trial. Trials, 18(1), Article 53. https://doi.org/10.1186/s13063-017-1779-9

Background Blinding is the process of keeping treatment assignment hidden and is used to minimise the possibility of bias. Trials at high risk of bias have been shown to report larger treatment effects than low risk studies. In dermatology, one popu... Read More about Investigating the effect of independent blinded digital image assessment on the STOP GAP trial.

What influences healthcare professionals' treatment preferences for older women with operable breast cancer?: an application of the discrete choice experiment (2017)
Journal Article
Morgan, J., Walters, S., Collins, K., Robinson, T., Cheung, K., Audisio, R., …Wyld, L. (2017). What influences healthcare professionals' treatment preferences for older women with operable breast cancer?: an application of the discrete choice experiment. EJSO - European Journal of Surgical Oncology, 43(7), https://doi.org/10.1016/j.ejso.2017.01.012

Introduction Primary endocrine therapy (PET) is used variably in the UK as an alternative to surgery for older women with operable breast cancer. Guidelines state that only patients with “significant comorbidity” or “reduced life expectancy” shoul... Read More about What influences healthcare professionals' treatment preferences for older women with operable breast cancer?: an application of the discrete choice experiment.

Does achieving the best practice tariff improve outcomes in hip fracture patients? An observational cohort study (2017)
Journal Article
Oakley, B., Nightingale, J., Moran, C. G., & Moppett, I. K. (2017). Does achieving the best practice tariff improve outcomes in hip fracture patients? An observational cohort study. BMJ Open, 7(2), https://doi.org/10.1136/bmjopen-2016-014190

Objectives: To determine if the introduction of the best practice tariff (BPT) has improved survival of the elderly hip fracture population, or if achieving BPT results in improved survival for an individual. Setting: A single university-affiliated... Read More about Does achieving the best practice tariff improve outcomes in hip fracture patients? An observational cohort study.

Suffering with dementia: the other side of "living well" (2017)
Journal Article
Bartlett, R., Windemuth-Wolfson, L., Oliver, K., & Dening, T. (2017). Suffering with dementia: the other side of "living well". International Psychogeriatrics, 29(2), https://doi.org/10.1017/S104161021600199X

In this editorial, we challenge the current understanding of “Living Well with Dementia.” Such discourse introduces the possibility of not living well with the condition or even of “living badly with dementia.” Numerous words might be relevant here –... Read More about Suffering with dementia: the other side of "living well".

A survey of eMedia-delivered interventions for schizophrenia used in randomized controlled trials (2017)
Journal Article
Naeem, F., Munschi, T., Xiang, S., Yang, M., Shokraneh, F., Syed, Y., …Farooq, S. (2017). A survey of eMedia-delivered interventions for schizophrenia used in randomized controlled trials. Neuropsychiatric Disease and Treatment, 13, 233-243. https://doi.org/10.2147/NDT.S115897

Background: Randomized trials evaluating electronic Media (eMedia) delivery of interventions are increasingly frequent in mental health. Although a number of reviews have reported efficacy of these interventions, none has reviewed the type of eMedia... Read More about A survey of eMedia-delivered interventions for schizophrenia used in randomized controlled trials.

Twittering on about mental health: is it worth the effort? (2017)
Journal Article
Jayaram, M., Moran, L., & Adams, C. (2017). Twittering on about mental health: is it worth the effort?. Evidence-Based Mental Health, 20(1), https://doi.org/10.1136/eb-2016-102580

The medical community disseminates information increasingly using social media. Randomised controlled trials are being conducted in this area to evaluate effectiveness of social media with mixed results so far, but more trials are likely to be publis... Read More about Twittering on about mental health: is it worth the effort?.

Video gaming and gaming addiction in transgender people: an exploratory study (2017)
Journal Article
Arcelus, J., Bouman, W. P., Richards, C., Jimenez-Murcia, S., & Griffiths, M. (in press). Video gaming and gaming addiction in transgender people: an exploratory study. Journal of Behavioral Addictions, https://doi.org/10.1556/2006.6.2017.002

Background: There is anecdotal clinical evidence that transgender people use the online world – such as forums and online video gaming – for the purpose of experiencing their gender identity in a safe, non-threatening, non alienating, nonstigmatizing... Read More about Video gaming and gaming addiction in transgender people: an exploratory study.

Early engagement in physical activity and exercise is key in managing cancer cachexia (2017)
Journal Article
Bayly, J., Wilcock, A., Higginson, I. J., & Maddocks, M. (2017). Early engagement in physical activity and exercise is key in managing cancer cachexia. Oncology, 31(1),

Despite consensus on the diagnosis and staging of cancer anorexia/cachexia syndrome, there is currently no accepted standard of care, and affected patients remain widely undertreated. There is general agreement that, because of the complex pathophysi... Read More about Early engagement in physical activity and exercise is key in managing cancer cachexia.

Fibrin glue for pilonidal sinus disease (2017)
Journal Article
Lund, J. N., Tou, S., Doleman, B., & Williams, J. P. (in press). Fibrin glue for pilonidal sinus disease. Cochrane Database of Systematic Reviews, 2017(1), Article CD011923. https://doi.org/10.1002/14651858.CD011923.pub2

Background Pilonidal sinus disease is a common condition that mainly affects young adults. This condition can cause significant pain and impairment of normal activities. No consensus currently exists on the optimum treatment for pilonidal sinus and... Read More about Fibrin glue for pilonidal sinus disease.

Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA (2017)
Journal Article
Nwosu, L. N., Allen, M., Wyatt, L., Huebner, J., Chapman, V., Walsh, D. A., & Kraus, V. (2017). Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA. Osteoarthritis and Cartilage, 25(6), https://doi.org/10.1016/j.joca.2017.01.002

Objectives: To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K, indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). Methods: Sera and... Read More about Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA.

Neuroimaging biomarkers predict brain structural connectivity change in a mouse model of vascular cognitive impairment (2017)
Journal Article
Boehm-Sturm, P., Füchtemeier, M., Foddis, M., Mueller, S., Trueman, R. C., Zille, M., …Farr, T. D. (in press). Neuroimaging biomarkers predict brain structural connectivity change in a mouse model of vascular cognitive impairment. Stroke, 48(1), https://doi.org/10.1161/STROKEAHA.116.014394

Background and Purpose�Chronic hypoperfusion in the mouse brain has been suggested to mimic aspects of vascular cognitive impairment, such as white matter damage. Although this model has attracted attention, our group has struggled to generate a reli... Read More about Neuroimaging biomarkers predict brain structural connectivity change in a mouse model of vascular cognitive impairment.