All Outputs (145)

Oestrogen receptor negative early operable primary breast cancer in older women—biological characteristics and long-term clinical outcome (2017)
Journal Article

Background Older women are at the greatest risk of breast cancer development and a considerable number present with comorbidities. Although the majority of breast cancers in this age group express oestrogen receptor (ER), which makes endocrine the... Read More about Oestrogen receptor negative early operable primary breast cancer in older women—biological characteristics and long-term clinical outcome.

Proportion of contextual effects in the treatment of fibromyalgia - a meta-analysis of randomised controlled trials (2017)
Journal Article

Objectives: To examine the proportion of the total treatment effect that is attributable to contextual effects in randomised controlled trials (RCTs) of treatments for fibromyalgia. Methods: A systematic literature search was undertaken in Medline,... Read More about Proportion of contextual effects in the treatment of fibromyalgia - a meta-analysis of randomised controlled trials.

IL-6 and IL-10 are associated with good prognosis in early stage invasive breast cancer patients (2017)
Journal Article

Macrophage-associated cytokines play an important role in cancer metastasis however the functions of Interleukins (IL) 6 and 10 in breast cancer (BC) progression and metastasis are not clear. In this study the roles of IL-6/IL-10 in regulating vascul... Read More about IL-6 and IL-10 are associated with good prognosis in early stage invasive breast cancer patients.

Long term outcomes of daily oral vs. pulsed intravenous cyclophosphamide in a non-trial setting in ANCA associated vasculitis (2017)
Journal Article

Objectives We aimed to compare risk of death, relapse, neutropenia and infection requiring hospital admission between unselected ANCA-associated vasculitis (AAV) patients according to whether cyclophosphamide induction was by daily oral (PO) or pulse... Read More about Long term outcomes of daily oral vs. pulsed intravenous cyclophosphamide in a non-trial setting in ANCA associated vasculitis.

Establishing the cascade of care for hepatitis C in England-benchmarking to monitor impact of direct acting antivirals (2017)
Journal Article

Little is known about engagement and retention in care of people diagnosed with chronic hepatitis C (HCV) in England. Establishing a cascade of care informs targeted interventions for improving case-finding, referral, treatment uptake and retention i... Read More about Establishing the cascade of care for hepatitis C in England-benchmarking to monitor impact of direct acting antivirals.

Transcriptomic analysis in pediatric spinal ependymoma reveals distinct molecular signatures (2017)
Journal Article

Pediatric spinal ependymomas (SEPN) are important albeit uncommon malignant central nervous system tumors with limited treatment options. Our current knowledge about the underlying biology of these tumors is limited due to their rarity. To begin to e... Read More about Transcriptomic analysis in pediatric spinal ependymoma reveals distinct molecular signatures.

Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation (2017)
Journal Article

Mesenchymal stem cells play a vital role in bone formation process by differentiating into osteoblasts, in a tissue that offers not a flat but a discontinuous three-dimensional (3D) topography in vivo. In order to understand how geometry may be affec... Read More about Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation.

Which outcomes are reported in cellulitis trials?: results of a review of outcomes included in cellulitis trials and a patient priority setting survey (2017)
Journal Article

Background There is an emerging need to develop consistent outcomes in clinical trials to allow effective comparison of treatment effects. No systematic review has previously looked at the reporting of outcome measures used in randomised controlle... Read More about Which outcomes are reported in cellulitis trials?: results of a review of outcomes included in cellulitis trials and a patient priority setting survey.

Feed thickener for infants up to six months of age with gastro-oesophageal reflux (Review) (2017)
Journal Article

Background Gastro-oesophageal reflux (GOR) is common in infants, and feed thickeners are often used to manage it in infants as they are simple to use and perceived to be harmless. However, conflicting evidence exists to support the use of feed thick... Read More about Feed thickener for infants up to six months of age with gastro-oesophageal reflux (Review).

Quality of questionnaires for the assessment of otitis media with effusion in children (2017)
Journal Article

Objectives Audiometric tests provide information about hearing in otitis media with effusion (OME). Questionnaires can supplement this information by supporting clinical history‐taking as well as potentially providing a standardized and comprehensiv... Read More about Quality of questionnaires for the assessment of otitis media with effusion in children.

Invasion in breast lesions: the role of the epithelial-stroma barrier (2017)
Journal Article

Despite the significant biological, behavioural and management differences between ductal carcinoma in situ (DCIS) and invasive carcinoma of the breast, they share many morphological and molecular similarities. Differentiation of these two different... Read More about Invasion in breast lesions: the role of the epithelial-stroma barrier.

The association between cognitive performance and speech-­in-noise perception for adult listeners: a systematic literature review and meta­‐analysis (2017)
Journal Article

Published studies assessing the association between cognitive performance and speech-in-noise perception examine different aspects of each, test different listeners, and often report quite variable associations. By examining the published evidence ba... Read More about The association between cognitive performance and speech-­in-noise perception for adult listeners: a systematic literature review and meta­‐analysis.

What is home? An art-based workshop to explore the physical, relational and wellbeing properties of Home (2017)
Journal Article

This feasibility study was framed under the notion of creative practices as mutual recovery – the idea that shared creativity, collective experience and mutual benefit can promote resilience in mental health and well-being. The study evaluated the im... Read More about What is home? An art-based workshop to explore the physical, relational and wellbeing properties of Home.

Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy (2017)
Journal Article

Objective: To characterize the phenotypic spectrum, molecular genetic findings, and functional consequences of pathogenic variants in early-onset KCNT1 epilepsy. Methods: We identified a cohort of 31 patients with epilepsy of infancy with migrating... Read More about Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy.

The minimum monitoring signal-to-noise ratio for off-axis signals and its implications for directional hearing aids (2017)
Journal Article

The signal-to-noise ratio (SNR) benefit of hearing aid directional microphones is dependent on the angle of the listener relative to the target, something that can change drastically and dynamically in a typical group conversation. When a new target... Read More about The minimum monitoring signal-to-noise ratio for off-axis signals and its implications for directional hearing aids.

Diagnostic challenges in papillary lesions of the breast (2017)
Journal Article

Papillary lesions of the breast comprise a heterogeneous group of diseases ranging from benign and atypical lesions to malignant tumours including non-invasive and invasive entities. Although diagnosis of papillary lesions featuring typical histologi... Read More about Diagnostic challenges in papillary lesions of the breast.

Veterinarian nominated common conditions of rabbits and guinea pigs compared with published literature (2017)
Journal Article

Rabbits and guinea pigs are increasingly popular pets in the UK, yet little is known about their common ailments, or how these relate to what appears in the published literature. The aim of this study was to characterise the common conditions of rabb... Read More about Veterinarian nominated common conditions of rabbits and guinea pigs compared with published literature.

Exercise-induced ‘browning’ of adipose tissues (2017)
Journal Article

Global rates of obesity continue to rise and are necessarily the consequence of a long-term imbalance between energy intake and energy expenditure. This is the result of an expansion of adipose tissue due to both the hypertrophy of existing adipocyte... Read More about Exercise-induced ‘browning’ of adipose tissues.

Quality of life in people with vitiligo: a systematic review and meta-analysis (2017)
Journal Article

Vitiligo is cosmetically disfiguring and has profound psychosocial effects due to stigmatization, problems in sexual function, anxiety, self-esteem and difficulty finding employment. Previous studies suggest a reduction in quality of life (QoL) due t... Read More about Quality of life in people with vitiligo: a systematic review and meta-analysis.

'When it goes back to my normal I suppose': A qualitative study using online focus groups to explore perceptions of 'control' among people with eczema and parents of children with eczema in the UK (2017)
Journal Article

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Objective: To inform the development of a core outcome set... Read More about 'When it goes back to my normal I suppose': A qualitative study using online focus groups to explore perceptions of 'control' among people with eczema and parents of children with eczema in the UK.