All Outputs (820)

Teledermatology for the diagnosis of skin cancer in adults (2018)
Journal Article
Chuchu, N., Dinnes, J., Takwoingi, Y., Matin, R. N., Bayliss, S. E., Davenport, C., …Williams, H. C. (2018). Teledermatology for the diagnosis of skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013193. https://doi.org/10.1002/14651858.CD013193

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high risk skin cancers which have the potential to metast... Read More about Teledermatology for the diagnosis of skin cancer in adults.

Exfoliative cytology for the diagnosis of basal cell carcinoma and other skin cancers in adults (2018)
Journal Article
Ferrante di Ruffano, L., Dinnes, J., Chuchu, N., Bayliss, S. E., Takwoingi, Y., Davenport, C., …Williams, H. C. (2018). Exfoliative cytology for the diagnosis of basal cell carcinoma and other skin cancers in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013187. https://doi.org/10.1002/14651858.CD013187

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to reduce morbidity and improve survival. Basal cell carcinoma (BCC) is usually localised to the skin with potential to infiltrate and dama... Read More about Exfoliative cytology for the diagnosis of basal cell carcinoma and other skin cancers in adults.

Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma (2018)
Journal Article
Chuchu, N., Takwoingi, Y., Dinnes, J., Matin, R. N., Bassett, O., Moreau, J. F., …Williams, H. C. (2018). Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma. Cochrane Database of Systematic Reviews, 2018(12), Article CD013192. https://doi.org/10.1002/14651858.CD013192

Background: Melanoma accounts for a small proportion of all skin cancer cases but is responsible for the majority of skin cancer-related deaths. Early detection and treatment can improve survival. Smartphone applications are readily accessible and po... Read More about Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma.

Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS (2018)
Journal Article
Dahabiyeh, L. A., Tooth, D., Carrell, R. W., Read, R. J., Yan, Y., Pipkin, F. B., & Barrett, D. A. (2019). Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS. Analytical and Bioanalytical Chemistry, 411(2), 427–437. https://doi.org/10.1007/s00216-018-1455-2

Angiotensinogen (AGT) is a critical protein in the renin-angiotensin-aldosterone system and may have an important role in the pathogenesis of pre-eclampsia. The disulphide linkage between cysteines 18 and 138 has a key role in the redox switch of AGT... Read More about Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS.

Imagined constructed thought: how staff interpret the behaviour of patients with intellectual disabilities (2018)
Journal Article
Webb, J. C., Pilnick, A., & Clegg, J. (2018). Imagined constructed thought: how staff interpret the behaviour of patients with intellectual disabilities. Research on Language and Social Interaction, 51(4), 347-362. https://doi.org/10.1080/08351813.2018.1523893

This paper examines ‘imagined constructed thought’: speakers giving voice to the inner world of a non-present other. Drawing on 9 hours of video footage of health-care staff discussing patients with intellectual disabilities during Discovery Awarenes... Read More about Imagined constructed thought: how staff interpret the behaviour of patients with intellectual disabilities.

Limitations of current in vitro models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma (2018)
Journal Article
Rogers, H. A., Chapman, R., Kings, H., Allard, J., Barron-Hastings, J., Pajtler, K. W., …Grundy, R. G. (2018). Limitations of current in vitro models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma. Oncotarget, 9(92), 36530-36541. https://doi.org/10.18632/oncotarget.26370

Background: Epigenetic modifications have been shown to play an important role in the classification and pathogenesis of the pediatric brain tumor ependymoma, suggesting they are a potential therapeutic target.

Results: Agents targeting epigenetic... Read More about Limitations of current in vitro models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma.

Clinical assessment of depth sensor based pose estimation algorithms for technology supervised rehabilitation applications (2018)
Journal Article
Sarsfield, J., Brown, D., Sherkat, N., Langensiepen, C., Lewis, J., Taheri, M., …Hughes, E. (2019). Clinical assessment of depth sensor based pose estimation algorithms for technology supervised rehabilitation applications. International Journal of Medical Informatics, 121, 30-38. https://doi.org/10.1016/j.ijmedinf.2018.11.001

Encouraging rehabilitation by the use of technology in the home can be a cost-effective strategy, particularly if consumer-level equipment can be used. We present a clinical qualitative and quantitative analysis of the pose estimation algorithms of a... Read More about Clinical assessment of depth sensor based pose estimation algorithms for technology supervised rehabilitation applications.

A tolerability and patient acceptability pilot study of a novel antimicrobial urinary catheter for long-term use (2018)
Journal Article
Belfield, K., Betts, H., Parkinson, R., & Bayston, R. (2018). A tolerability and patient acceptability pilot study of a novel antimicrobial urinary catheter for long-term use. Neurourology and Urodynamics, 38(1), 338-345. https://doi.org/10.1002/nau.23858

© 2018 Wiley Periodicals, Inc. Aims: We have developed a novel antimicrobial urinary catheter (AUC) impregnated with rifampicin, triclosan, and sparfloxacin and demonstrated that it has long-term (∼84 days) protection against bacterial colonization i... Read More about A tolerability and patient acceptability pilot study of a novel antimicrobial urinary catheter for long-term use.

Developing an integrated rehabilitation model for thoracic cancer services: views of patients, carers and clinicians (2018)
Journal Article
Bayly, J., Edwards, B. E., Peat, N., Warwick, G., Hennig, I. M., Arora, A., …Maddocks, M. (2018). Developing an integrated rehabilitation model for thoracic cancer services: views of patients, carers and clinicians. Pilot and Feasibility Studies, 4, 1-12. https://doi.org/10.1186/s40814-018-0350-0

Background: Access to rehabilitation to prevent disability and optimise function is recommended for patients with cancer, including following cancer diagnosis. Models to integrate rehabilitation within oncology services as cancer treatment commences... Read More about Developing an integrated rehabilitation model for thoracic cancer services: views of patients, carers and clinicians.

The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation (2018)
Journal Article
L, R., LJ, S., JM, B., CA, R., KM, T., S, H., …Wheatley, T. (2019). The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation. Journal of Clinical Epidemiology, 106, 108-120. https://doi.org/10.1016/j.jclinepi.2018.10.004

Objective
To evaluate the impact of the Quintet Recruitment Intervention (QRI) on recruitment in challenging randomized controlled trials (RCTs) that have applied the intervention. The QRI aims to understand recruitment difficulties, and then implem... Read More about The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation.

Targeting PARP1 in XRCC1-deficient sporadic invasive breast cancer or preinvasive ductal carcinoma in situ induces synthetic lethality and chemoprevention (2018)
Journal Article
Ali, R., Al-Kawaz, A., Toss, M. S., Green, A. R., Miligy, I. M., Mesquita, K. A., …Madhusudan, S. (2018). Targeting PARP1 in XRCC1-deficient sporadic invasive breast cancer or preinvasive ductal carcinoma in situ induces synthetic lethality and chemoprevention. Cancer Research, 78(24), 6818-6827. https://doi.org/10.1158/0008-5472.CAN-18-0633

© 2018 American Association for Cancer Research. Targeting PARP1 for synthetic lethality is a new strategy for breast cancers harboring germline mutations in BRCA. However, these mutations are rare, and reactivation of BRCA-mediated pathways may resu... Read More about Targeting PARP1 in XRCC1-deficient sporadic invasive breast cancer or preinvasive ductal carcinoma in situ induces synthetic lethality and chemoprevention.

Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging (2018)
Journal Article
Nizamudeen, Z., Markus, R., Lodge, R., Parmenter, C., Platt, M., Chakrabarti, L., & Sottile, V. (2018). Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1865(12), 1891-1900. https://doi.org/10.1016/j.bbamcr.2018.09.008

Extracellular vesicles (EVs) have prevalent roles in cancer biology and regenerative medicine. Conventional techniques for characterising EVs including electron microscopy (EM), nanoparticle tracking analysis (NTA) and tuneable resistive pulse sensin... Read More about Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging.

A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults (2018)
Journal Article
Din, U., Brook, M., Selby, A. L., Quinlan, J. I., Boereboom, C., Abdullah, H., …Smith, K. (2019). A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults. Clinical Nutrition, 38(5), 2071-2078. https://doi.org/10.1016/j.clnu.2018.09.025

Age-related sarcopenia and dynapenia are associated with frailty and metabolic diseases. Resistance exercise training (RET) adjuvant to evidence-based nutritional intervention(s) have been shown as mitigating strategies. Given that HMB supplementatio... Read More about A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults.

Automated quality control for within and between studies diffusion MRI data using a non-parametric framework for movement and distortion correction (2018)
Journal Article
Bastiani, M., Cottaar, M., Fitzgibbon, S. P., Suri, S., Alfaro-Almagro, F., Sotiropoulos, S. N., …Andersson, J. (2019). Automated quality control for within and between studies diffusion MRI data using a non-parametric framework for movement and distortion correction. NeuroImage, 184, 801-812. https://doi.org/10.1016/j.neuroimage.2018.09.073

Diffusion MRI data can be affected by hardware and subject-related artefacts that can adversely affect downstream analyses. Therefore, automated quality control (QC) is of great importance, especially in large population studies where visual QC is no... Read More about Automated quality control for within and between studies diffusion MRI data using a non-parametric framework for movement and distortion correction.

Urinary extracellular vesicle protein profiling and endogenous lithium clearance support excessive renal sodium wasting and water reabsorption in thiazide induced hyponatremia (2018)
Journal Article
Channavajjhala, S. K., Bramley, R., Peltz, T., Oosthuyzen, W., Jia, W., Kinnear, S., …Glover, M. (2019). Urinary extracellular vesicle protein profiling and endogenous lithium clearance support excessive renal sodium wasting and water reabsorption in thiazide induced hyponatremia. Kidney International Reports, 4(1), 139-147. https://doi.org/10.1016/j.ekir.2018.09.011

Introduction

Thiazide diuretics are amongst the most widely used anti-hypertensive medicines worldwide. Thiazide-Induced Hyponatremia (TIH) is one of their most clinically significant adverse effects. A priori TIH must result from excessive saliur... Read More about Urinary extracellular vesicle protein profiling and endogenous lithium clearance support excessive renal sodium wasting and water reabsorption in thiazide induced hyponatremia.

Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training (2018)
Journal Article
Ahtiainen, J. P., Lensu, S., Ruotsalainen, I., Schumann, M., Ihalainen, J. K., Fachada, V., …Kainulainen, H. (2018). Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training. Experimental Physiology, https://doi.org/10.1113/ep087144

The purpose of this study was to determine whether rats selectively bred for low and high response to aerobic exercise training co-segregate for differences in muscle adaptations to ladder-climbing resistance training. Five high-responder (HRT) and f... Read More about Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training.

Short-term (<8 weeks) high-intensity interval training in diseased cohorts (2018)
Journal Article
Blackwell, J. E., Doleman, B., Herrod, P., Ricketts, S., Phillips, B. E., Lund, J. N., & Williams, J. P. (2018). Short-term (

Background & Aim:
Exercise training regimes can lead to improvements in measures of cardiorespiratory fitness (CRF), improved general health, and reduced morbidity and overall mortality risk. High intensity interval training (HIIT) offers a time-eff... Read More about Short-term (<8 weeks) high-intensity interval training in diseased cohorts.

Short-Term Impact of Bariatric Surgery on Best-Corrected Distance Visual Acuity and Diabetic Retinopathy Progression (2018)
Journal Article
Richardson, P., Hulpus, A., & Idris, I. (2018). Short-Term Impact of Bariatric Surgery on Best-Corrected Distance Visual Acuity and Diabetic Retinopathy Progression. Obesity Surgery, 28(11), 3711-3713. https://doi.org/10.1007/s11695-018-3445-z

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. The immediate impact of rapid glucose lowering induced by bariatric surgery on diabetic retinopathy (DR) progression remains unclear. We present 3-year changes in the best-correct... Read More about Short-Term Impact of Bariatric Surgery on Best-Corrected Distance Visual Acuity and Diabetic Retinopathy Progression.

The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells (2018)
Journal Article
Crossland, H., Smith, K., Atherton, P. J., & Wilkinson, D. J. (2018). The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells. Journal of Cellular Physiology, 233(12), 9663-9673. https://doi.org/10.1002/jcp.26881

Hyperammonaemia and hyperethanolaemia are thought to be driving factors behind skeletal muscle myopathy in liver disease i.e. cirrhosis. Despite this, the singular and combined impacts of ethanol and ammonia induced protein catabolism are poorly defi... Read More about The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells.

Attachment style, psychotic phenomena and the relationship with aggression: investigation in a general population sample (2018)
Journal Article
Whale, K., Green, K., & Browne, K. (2019). Attachment style, psychotic phenomena and the relationship with aggression: investigation in a general population sample. Journal of Aggression, Conflict and Peace Research, 11(1), 47-58. https://doi.org/10.1108/JACPR-04-2018-0356

Purpose: This study aimed to explore the relationship between attachment style, sub-clinical symptoms of psychosis and aggression in a general population sample.
Design: Using both convenience and snowball sampling, participants in the community (n=... Read More about Attachment style, psychotic phenomena and the relationship with aggression: investigation in a general population sample.