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Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training

Ahtiainen, Juha P.; Lensu, Sanna; Ruotsalainen, Ilona; Schumann, Moritz; Ihalainen, Johanna K.; Fachada, Vasco; Mendias, Christopher L.; Brook, Matthew S.; Smith, Kenneth; Atherton, Philip J.; Koch, Lauren G.; Britton, Steven L.; Kainulainen, Heikki

Authors

Juha P. Ahtiainen

Sanna Lensu

Ilona Ruotsalainen

Moritz Schumann

Johanna K. Ihalainen

Vasco Fachada

Christopher L. Mendias

KENNETH SMITH KEN.SMITH@NOTTINGHAM.AC.UK
Professor of Metabolic Mass Spectrometry

PHILIP ATHERTON philip.atherton@nottingham.ac.uk
Professor of Clinical, metabolic & Molecular Physiology

Lauren G. Koch

Steven L. Britton

Heikki Kainulainen



Abstract

The purpose of this study was to determine whether rats selectively bred for low and high response to aerobic exercise training co-segregate for differences in muscle adaptations to ladder-climbing resistance training. Five high-responder (HRT) and five low-responder (LRT) rats completed the resistance training, while six HRT and six LRT rats served as sedentary control animals. Before and after the 6 week intervention, body composition was determined by dual energy X-ray absorptiometry. Before tissue harvesting, the right triceps surae muscles were loaded by electrical stimulation. Muscle fibre cross-sectional areas, nuclei per cell, phosphorylation status of selected signalling proteins of mTOR and Smad pathways, and muscle protein, DNA and RNA concentrations were determined for the right gastrocnemius muscle. The daily protein synthesis rate was determined by the deuterium oxide method from the left quadriceps femoris muscle. Tissue weights of fore- and hindlimb muscles were measured. In response to resistance training, maximal carrying capacity was greater in HRT (∼3.3 times body mass) than LRT (∼2.5 times body mass), indicating greater improvements of strength in HRT. However, muscle hypertrophy that could be related to greater strength gains in HRT was not observed. Furthermore, noteworthy changes within the experimental groups or differences between groups were not observed in the present measures. The lack of hypertrophic muscular adaptations despite considerable increases in muscular strength suggest that adaptations to the present ladder-climbing training in HRT and LRT rats were largely induced by neural adaptations.

Journal Article Type Article
Publication Date Oct 9, 2018
Journal Experimental Physiology
Print ISSN 0958-0670
Publisher Wiley
Peer Reviewed Peer Reviewed
APA6 Citation Ahtiainen, J. P., Lensu, S., Ruotsalainen, I., Schumann, M., Ihalainen, J. K., Fachada, V., …Kainulainen, H. (2018). Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training. Experimental Physiology, doi:10.1113/ep087144
DOI https://doi.org/10.1113/ep087144
Keywords Physiology
Publisher URL https://physoc.onlinelibrary.wiley.com/doi/epdf/10.1113/EP087144

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