All Outputs (1461)

Applications and limitations of measuring environmental DNA as indicators of the presence of aquatic animals (2015)
Journal Article
Rees, H. C., Gough, K. C., Middleditch, D. J., Patmore, J. R., & Maddison, B. C. (2015). Applications and limitations of measuring environmental DNA as indicators of the presence of aquatic animals. Journal of Applied Ecology, 52(4), https://doi.org/10.1111/1365-2664.12467

1. In Rees et al. (2014b), we reviewed the current status of environmental DNA (eDN A) tomonitor aquatic populations. Our aim was to focus on discus sion of methodologies used,application of eDNA analysis as a survey tool in ecology, and to include s... Read More about Applications and limitations of measuring environmental DNA as indicators of the presence of aquatic animals.

Use of stochastic simulation to evaluate the reduction in methane emissions and improvement in reproductive efficiency from routine hormonal interventions in dairy herds (2015)
Journal Article
Archer, S. C., Hudson, C., & Green, M. J. (2015). Use of stochastic simulation to evaluate the reduction in methane emissions and improvement in reproductive efficiency from routine hormonal interventions in dairy herds. PLoS ONE, 10(6), Article e0127846. https://doi.org/10.1371/journal.pone.0127846

This study predicts the magnitude and between herd variation in changes of methane emissions and production efficiency associated with interventions to improve reproductive efficiency in dairy cows. Data for 10,000 herds of 200 cows were simulated. P... Read More about Use of stochastic simulation to evaluate the reduction in methane emissions and improvement in reproductive efficiency from routine hormonal interventions in dairy herds.

Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity (2015)
Journal Article
Mussai, F., Egan, S. A., Hunter, S., Webber, H., Fisher, J., Wheat, R., …De Santo, C. (2015). Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity. Cancer Research, 75(15), https://doi.org/10.1158/0008-5472.CAN-14-3443

Neuroblastoma is the most common extra cranial solid tumour of childhood, and survival remains poor for patients with advanced disease. Novel immune therapies are currently in development, but clinical outcomes have not matched preclinical results. H... Read More about Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity.

Does the Presence of Scrapie Affect the Ability of Current Statutory Discriminatory Tests To Detect the Presence of Bovine Spongiform Encephalopathy? (2015)
Journal Article
Maddison, B. C., Gough, K. C., Bishop, K., Simmons, M. M., Chaplin, M. J., Vickery, C. M., …Spiropoulos, J. (2015). Does the Presence of Scrapie Affect the Ability of Current Statutory Discriminatory Tests To Detect the Presence of Bovine Spongiform Encephalopathy?. Journal of Clinical Microbiology, 53(8), 2593-2604. https://doi.org/10.1128/jcm.00508-15

Current European Commission (EC) surveillance regulations require discriminatory testing of all transmissible spongiform encephalopathy (TSE)-positive small ruminant (SR) samples in order to classify them as bovine spongiform encephalopathy (BSE) or... Read More about Does the Presence of Scrapie Affect the Ability of Current Statutory Discriminatory Tests To Detect the Presence of Bovine Spongiform Encephalopathy?.

DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS (2015)
Journal Article
Glossop, J. R., Haworth, K. E., Emes, R. D., Nixon, N. B., Packham, J. C., Dawes, P. T., …Farrell, W. E. (2015). DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS. Epigenomics, 7(4), https://doi.org/10.2217/epi.15.15

Aims: Alterations in DNA methylation contribute to the abnormal phenotype of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA). Herein, we performed genome-wide DNA methylation profiling of RA FLS derived from synovial f... Read More about DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS.

Regulation of vascular endothelial growth factor in prostate cancer (2015)
Journal Article
de Brot, S., Ntekim, A., Cardenas, R., James, V., Allegrucci, C., Heery, D. M., …Mongan, N. P. (2015). Regulation of vascular endothelial growth factor in prostate cancer. Endocrine-Related Cancer, 22(3), Article R107-R123. https://doi.org/10.1530/ERC-15-0123

Prostate cancer (PCa) is the most common malignancy affecting men in the western world. Although radical prostatectomy and radiation therapy can successfully treat PCa in the majority of patients, up to ∼30% will experience local recurrence or metast... Read More about Regulation of vascular endothelial growth factor in prostate cancer.

Cattle veterinarians' awareness and understanding of biosecurity (2015)
Journal Article
Pritchard, K., Wapenaar, W., & Brennan, M. L. (2015). Cattle veterinarians' awareness and understanding of biosecurity. Veterinary Record, 176(21), Article 546. https://doi.org/10.1136/vr.102899

PREVENTIVE biosecurity measures, such as isolation of purchased animals, are well documented in the literature (Duncan 1990, Maunsell and Donovan 2008, Noremark and others 2009) and biosecurity has been highlighted as a key intervention for many of t... Read More about Cattle veterinarians' awareness and understanding of biosecurity.

Semen quality, testicular B-mode and Doppler ultrasound, and serum testosterone concentrations in dogs with established infertility (2015)
Journal Article
de Souza, M. B., England, G. C., Mota Filho, A. C., Ackermann, C. L., Sousa, C. V. S., de Carvalho, G. G., …da Silva, L. D. M. (in press). Semen quality, testicular B-mode and Doppler ultrasound, and serum testosterone concentrations in dogs with established infertility. Theriogenology, 84(5), https://doi.org/10.1016/j.theriogenology.2015.05.015

Retrospective examination of breeding records enabled the identification of 10 dogs of normal fertility and 10 dogs with established infertility of at least 12 months of duration. Comparisons of testicular palpation, semen evaluation, testicular ultr... Read More about Semen quality, testicular B-mode and Doppler ultrasound, and serum testosterone concentrations in dogs with established infertility.

Opening up animal research and science-society relations?: a thematic analysis of transparency discourses in the United Kingdom (2015)
Journal Article
McLeod, C., & Hobson-West, P. (2016). Opening up animal research and science-society relations?: a thematic analysis of transparency discourses in the United Kingdom. Public Understanding of Science, 25(7), https://doi.org/10.1177/0963662515586320

The use of animals in scientific research represents an interesting case to consider in the context of the contemporary preoccupation with transparency and openness in science and governance. In the United Kingdom, organisations critical of animal re... Read More about Opening up animal research and science-society relations?: a thematic analysis of transparency discourses in the United Kingdom.

Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation (2015)
Journal Article
Orfali, N., O'Donovan, T. R., Nyhan, M. J., Britschgi, A., Tschan, M. P., Cahill, M. R., …McKenna, S. L. (2015). Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation. Experimental Hematology, 43(9), 781-793.e2. https://doi.org/10.1016/j.exphem.2015.04.012

Acute myeloid leukemia (AML) is characterized by the accumulation of immature blood cell precursors in the bone marrow. Pharmacologically overcoming the differentiation block in this condition is an attractive therapeutic avenue, which has achieved s... Read More about Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation.

Evaluation of treatments for claw horn lesions in dairy cows in a randomized controlled trial (2015)
Journal Article
Thomas, H., Miguel-Pacheco, G., Bollard, N., Archer, S., Bell, N., Mason, C., …Huxley, J. (2015). Evaluation of treatments for claw horn lesions in dairy cows in a randomized controlled trial. Journal of Dairy Science, 98(7), 4477-4486. https://doi.org/10.3168/jds.2014-8982

Lameness is one of the most significant endemic disease problems facing the dairy industry. Claw horn lesions (principally sole hemorrhage, sole ulcer, and white line disease) are some of the most prevalent conditions. Despite the fact that thousands... Read More about Evaluation of treatments for claw horn lesions in dairy cows in a randomized controlled trial.

Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease (2015)
Journal Article
Inns, J., & James, V. (2015). Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease. Breast, 24(4), 364-369. https://doi.org/10.1016/j.breast.2015.04.001

Breast cancer is the second most common malignancy diagnosed in women worldwide. The greatest cause of breast cancer mortality is development of metastasis. For many women metastasis is an early event in breast cancer which goes undetected until its... Read More about Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease.

Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time (2015)
Journal Article
Maddison, B. C., Spiropoulos, J., Vickery, C. M., Lockey, R., Owen, J. P., Bishop, K., …Gough, K. C. (2015). Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time. Veterinary Research, 46, Article 46. https://doi.org/10.1186/s13567-015-0179-y

Ovine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months and eluted prion was used to challenge tg338 mice transgenic for ovine PrP. After one-day incubation... Read More about Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time.

Sensitive recovery of recombinant antibody clones after their in silico identification within NGS datasets (2015)
Journal Article
Spiliotopoulos, A., Owen, J. P., Maddison, B. C., Dreveny, I., Rees, H. C., & Gough, K. C. (2015). Sensitive recovery of recombinant antibody clones after their in silico identification within NGS datasets. Journal of Immunological Methods, 420, https://doi.org/10.1016/j.jim.2015.03.005

Recently the analytical power of the latest high throughput next generation DNA sequencing platforms has been used to analyse phage that have been selected from the panning of large combinatorial libraries displaying either peptide or antibody ligand... Read More about Sensitive recovery of recombinant antibody clones after their in silico identification within NGS datasets.

Poor functional antibody responses are present in nearly all patients with chronic lymphocytic leukaemia, irrespective of total IgG concentration, and are associated with increased risk of infection (2015)
Journal Article
Parry, H. M., Birtwistle, J., Whitelegg, A., Hudson, C. D., McSkeane, T., Hazlewood, P., …Richter, A. G. (in press). Poor functional antibody responses are present in nearly all patients with chronic lymphocytic leukaemia, irrespective of total IgG concentration, and are associated with increased risk of infection. British Journal of Haematology, 171(5), https://doi.org/10.1111/bjh.13455

Gestational dietary protein is associated with sex specific decrease in blood flow, fetal heart growth and post-natal blood pressure of progeny (2015)
Journal Article

The incidence of adverse pregnancy outcomes is higher in pregnancies where the fetus is male. Sex specific differences in feto-placental perfusion indices identified by Doppler assessment have recently been associated with placental insufficiency and... Read More about Gestational dietary protein is associated with sex specific decrease in blood flow, fetal heart growth and post-natal blood pressure of progeny.

Virulence related sequences; insights provided by comparative genomics of Streptococcus uberis of differing virulence (2015)
Journal Article

Background

Streptococcus uberis, a Gram-positive, catalase-negative member of the family Streptococcaceae is an important environmental pathogen responsible for a significant proportion of subclinical and clinical bovine intramammary infections. C... Read More about Virulence related sequences; insights provided by comparative genomics of Streptococcus uberis of differing virulence.

Agreement between veterinary patient data collected from different sources (2015)
Journal Article
Robinson, N. J., Brennan, M. L., Cobb, M., & Dean, R. S. (in press). Agreement between veterinary patient data collected from different sources. Veterinary Journal, 205(1), https://doi.org/10.1016/j.tvjl.2015.04.023

Determining the accuracy of the electronic medical record (EMR) is vital to the progress of practice based research. The aim of this study was to determine the agreement between the EMR and other sources of signalment data. Data were gathered during... Read More about Agreement between veterinary patient data collected from different sources.

A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites (2015)
Journal Article
Winter, A. D., Gillan, V., Maitland, K., Emes, R. D., Roberts, B., McCormack, G., …Devaney, E. (2015). A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics, 16, Article e331. https://doi.org/10.1186/s12864-015-1536-y

Background: Filarial nematodes are important pathogens in the tropics transmitted to humans via the bite of blood sucking arthropod vectors. The molecular mechanisms underpinning survival and differentiation of these parasites following transmission... Read More about A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites.

Molecular epidemiology of nontyphoidal Salmonella in poultry and poultry products in India: implications for human health (2015)
Journal Article
Saravanan, S., Purushothaman, V., Murthy, T. R. G., Sukumar, K., Srinivasan, P., Gowthaman, V., …Kuchipudi, S. V. (2015). Molecular epidemiology of nontyphoidal Salmonella in poultry and poultry products in India: implications for human health. Indian Journal of Microbiology, 55(3), https://doi.org/10.1007/s12088-015-0530-z

Human infections with non-typhoidal Salmonella (NTS) serovars are increasingly becoming a threat to human health globally. While all motile Salmonellae have zoonotic potential, Salmonella Enteritidis and Salmonella Typhimurium are most commonly assoc... Read More about Molecular epidemiology of nontyphoidal Salmonella in poultry and poultry products in India: implications for human health.