The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer

Metzler, Veronika M.; de Brot, Simone; Haigh, Daisy B.; Woodcock, Corinne L.; Lothion-Roy, Jennifer; Harris, Anna E.; Nilsson, Emeli M.; Ntekim, Atara; Persson, Jenny L.; Robinson, Brian D.; Khani, Francesca; Laursen, Kristian B.; Gudas, Lorraine J.; Toss, Michael S.; Madhusudan, Srinivasan; Rakha, Emad; Heery, David M.; Rutland, Catrin S.; Mongan, Nigel P.; Jeyapalan, Jennie N.

doi:10.3389/fcell.2023.1116424

All Outputs (4)

Cardiovascular Stem Cell Applications in Experimental Animal Models (2023)
Book Chapter
Jeyapalan, J. N., Cockcroft, J., Rizvanov, A. A., Haider, K. H., & Rutland, C. S. (2023). Cardiovascular Stem Cell Applications in Experimental Animal Models. In K. H. Haider (Ed.), Cardiovascular Applications of Stem Cells (465-490). Springer Nature Singapore. https://doi.org/10.1007/978-981-99-0722-9_16

Stem cells are increasingly used in various species for differing diseases, most frequently experimentally. In addition, several animals are also used as models for both veterinary and human medicine. Differing stem cell types have been trialed with... Read More about Cardiovascular Stem Cell Applications in Experimental Animal Models.

Targeting DNA damage repair precision medicine strategies in cancer (2023)
Journal Article
Brownlie, J., Kulkarni, S., Algethami, M., Jeyapalan, J. N., Mongan, N. P., Rakha, E. A., & Madhusudan, S. (2023). Targeting DNA damage repair precision medicine strategies in cancer. Current Opinion in Pharmacology, 70, Article 102381. https://doi.org/10.1016/j.coph.2023.102381

DNA repair targeted therapeutics is a promising precision medicine strategy in cancer. The development and clinical use of PARP inhibitors has transformed lives for many patients with BRCA germline deficient breast and ovarian cancer as well as plati... Read More about Targeting DNA damage repair precision medicine strategies in cancer.

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer (2023)
Journal Article
Lothion-Roy, J., Haigh, D. B., Harris, A. E., Metzler, V. M., Alsaleem, M., Toss, M. S., …Woodcock, C. L. (2023). Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. Frontiers in Genetics, 13, Article 1096071. https://doi.org/10.3389/fgene.2022.1096071

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are... Read More about Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer (2023)
Journal Article
Metzler, V. M., de Brot, S., Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., …Jeyapalan, J. N. (2023). The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer. Frontiers in Cell and Developmental Biology, 11, Article 1116424. https://doi.org/10.3389/fcell.2023.1116424

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types... Read More about The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.