All Outputs (167)

Illuminating Host-Parasite Interaction at the Cellular and Subcellular Levels with Infrared Microspectroscopy (2022)
Journal Article
Elsheikha, H. M., Al-Sandaqchi, A. T., Harun, M. S., Winterton, F., Altharawi, A., Elsaied, N. A., …Chan, K. L. A. (2022). Illuminating Host-Parasite Interaction at the Cellular and Subcellular Levels with Infrared Microspectroscopy. Cells, 11(5), Article 811. https://doi.org/10.3390/cells11050811

Toxoplasma gondii (T. gondii) is an opportunistic protozoan that can cause brain infection and other serious health consequences in immuno-compromised individuals. This parasite has a remarkable ability to cross biological barriers and exploit the ho... Read More about Illuminating Host-Parasite Interaction at the Cellular and Subcellular Levels with Infrared Microspectroscopy.

All-Trans-Retinoic Acid Combined With Valproic Acid Can Promote Differentiation in Myeloid Leukemia Cells by an Autophagy Dependent Mechanism (2022)
Journal Article
Benjamin, D. N., O’Donovan, T. R., Laursen, K. B., Orfali, N., Cahill, M. R., Mongan, N. P., …McKenna, S. L. (2022). All-Trans-Retinoic Acid Combined With Valproic Acid Can Promote Differentiation in Myeloid Leukemia Cells by an Autophagy Dependent Mechanism. Frontiers in Oncology, 12, Article 848517. https://doi.org/10.3389/fonc.2022.848517

Acute myeloid leukemia (AML) is an aggressive blood cancer with an overall survival of 30%. One form of AML, acute promyelocytic leukemia (APL) has become more than 90% curable with differentiation therapy, consisting of all-trans-retinoic acid (ATRA... Read More about All-Trans-Retinoic Acid Combined With Valproic Acid Can Promote Differentiation in Myeloid Leukemia Cells by an Autophagy Dependent Mechanism.

Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage (2022)
Journal Article
Akhmetzyanova, E. R., Timofeeva, A. V., Sabirov, D. K., Kostennikov, A. A., Rogozhin, A. A., James, V., …Mukhamedshina, Y. O. (2022). Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage. Frontiers in Molecular Neuroscience, 14, Article 802558. https://doi.org/10.3389/fnmol.2021.802558

Determination of the quantitative composition of phenotypically and morphologically different populations of resident microglia and infiltrating macrophages in spinal cord injury (SCI) of various degrees of severity could lead to much needed novel th... Read More about Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage.

A systematic review, meta‐analysis and meta‐regression of the global prevalence of Toxoplasma gondii infection in wild marine mammals and associations with epidemiological variables (2022)
Journal Article
Li, M., Gao, X., Ma, J., Elsheikha, H. M., & Cong, W. (2022). A systematic review, meta‐analysis and meta‐regression of the global prevalence of Toxoplasma gondii infection in wild marine mammals and associations with epidemiological variables. Transboundary and Emerging Diseases, 69(5), e1213-e1230. https://doi.org/10.1111/tbed.14493

Toxoplasma gondii infection in wild marine mammals is a growing problem and is associated with adverse impacts on marine animal and public health. This systematic review, meta-analysis and meta-regression estimates the global prevalence of T. gondii... Read More about A systematic review, meta‐analysis and meta‐regression of the global prevalence of Toxoplasma gondii infection in wild marine mammals and associations with epidemiological variables.

Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity (2022)
Journal Article
Stott-Marshall, R. J., & Foster, T. L. (2022). Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity. Frontiers in Microbiology, 13, Article 840885. https://doi.org/10.3389/fmicb.2022.840885

In the absence of effective vaccines and treatments, annual outbreaks of severe human haemorrhagic fever caused by arenaviruses, such as Lassa virus, continue to pose a significant human health threat. Understanding the balance of cellular factors th... Read More about Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity.

Association of L-type amino acid transporter 1 (LAT1) with the immune system and prognosis in invasive breast cancer (2022)
Journal Article
Kurozumi, S., Kaira, K., Matsumoto, H., Kurosumi, M., Yokobori, T., Kanai, Y., …Horiguchi, J. (2022). Association of L-type amino acid transporter 1 (LAT1) with the immune system and prognosis in invasive breast cancer. Scientific Reports, 12(1), Article 2742. https://doi.org/10.1038/s41598-022-06615-8

L-type amino acid transporter 1 (LAT1), also referred to as SLC7A5, is believed to regulate tumor metabolism and be associated with tumor proliferation. In invasive breast cancer, we clinicopathologically investigated the utility of LAT1 expression.... Read More about Association of L-type amino acid transporter 1 (LAT1) with the immune system and prognosis in invasive breast cancer.

Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases (2022)
Journal Article
Ebanks, B., & Chakrabarti, L. (2022). Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases. Frontiers in Molecular Biosciences, 9, Article 854321. https://doi.org/10.3389/fmolb.2022.854321

The mitochondrial ATP synthase is responsible for the production of cellular ATP, and it does so by harnessing the membrane potential of the mitochondria that is produced by the sequential oxidation of select cellular metabolites. Since the structura... Read More about Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases.

Clearance of Maedi-visna infection in a longitudinal study of naturally infected rams is associated with homozygosity for the TMEM154 resistance allele (2022)
Journal Article
Jones, S., McKay, H., Eden, L., Bollard, N., Dunham, S., Davies, P., & Tarlinton, R. (2022). Clearance of Maedi-visna infection in a longitudinal study of naturally infected rams is associated with homozygosity for the TMEM154 resistance allele. Journal of Medical Microbiology, 71(2), Article 001506. https://doi.org/10.1099/jmm.0.001506

Maedi-visna (MV) is a lentiviral disease of sheep responsible for severe production losses in affected flocks. There are no vaccination or treatment options with control reliant on test and cull strategies. The most common diagnostic methods used at... Read More about Clearance of Maedi-visna infection in a longitudinal study of naturally infected rams is associated with homozygosity for the TMEM154 resistance allele.

Cellular and Molecular Gradients in the Ventral Horns With Increasing Distance From the Injury Site After Spinal Cord Contusion (2022)
Journal Article
Kabdesh, I. M., Mukhamedshina, Y. O., Arkhipova, S. S., Sabirov, D. K., Kuznecov, M. S., Vyshtakalyuk, A. B., …Chelyshev, Y. A. (2022). Cellular and Molecular Gradients in the Ventral Horns With Increasing Distance From the Injury Site After Spinal Cord Contusion. Frontiers in Cellular Neuroscience, 16, Article 817752. https://doi.org/10.3389/fncel.2022.817752

To identify cellular and molecular gradients following spinal cord injury (SCI), a rat contusion model of severe SCI was used to investigate the expression of NG2 and molecules that identify astrocytes and axons of the ventral horns (VH) at different... Read More about Cellular and Molecular Gradients in the Ventral Horns With Increasing Distance From the Injury Site After Spinal Cord Contusion.

Lessons from working across fields to develop a framework for informed choices (2022)
Journal Article
Stewart, R., Aronson, J. K., Barends, E., Boruch, R., Brennan, M., Chislett, J., …Vale, L. (2022). Lessons from working across fields to develop a framework for informed choices. Research for All, 6(1), https://doi.org/10.14324/rfa.06.1.05

In late 2018, Iain Chalmers, Andy Oxman and others from the Informed Health Choices team convened a cross-field forum to develop a generic framework of key concepts for thinking critically about claims, research and choices about interventions, with... Read More about Lessons from working across fields to develop a framework for informed choices.

Method development to characterise elephant tail hairs by LA-ICP-MS to reflect changes in elemental chemistry (2022)
Journal Article
Sach, F., Fields, L., Chenery, S., Yon, L., Henley, M. D., Buss, P., …Watts, M. J. (2023). Method development to characterise elephant tail hairs by LA-ICP-MS to reflect changes in elemental chemistry. Environmental Geochemistry and Health, 45(4), 1153-1164. https://doi.org/10.1007/s10653-022-01207-x

This paper evaluated analytical methods used to generate time-series data from elephant tail hairs, which can be used to reflect changing exposure to environmental geochemistry. Elephant tail hairs were analysed by three methods sequentially, each pr... Read More about Method development to characterise elephant tail hairs by LA-ICP-MS to reflect changes in elemental chemistry.

Ubiquitin-conjugating enzyme 2C (UBE2C) is a poor prognostic biomarker in invasive breast cancer (2022)
Journal Article
Kariri, Y., Toss, M. S., Alsaleem, M., Elsharawy, K. A., Joseph, C., Mongan, N. P., …Rakha, E. A. (2022). Ubiquitin-conjugating enzyme 2C (UBE2C) is a poor prognostic biomarker in invasive breast cancer. Breast Cancer Research and Treatment, 192(3), 529-539. https://doi.org/10.1007/s10549-022-06531-5

Background The Ubiquitin-conjugating enzyme 2C (UBE2C) is essential for the ubiquitin–proteasome system and is involved in cancer cell migration and apoptosis. This study aimed to determine the prognostic value of UBE2C in invasive breast cancer (BC... Read More about Ubiquitin-conjugating enzyme 2C (UBE2C) is a poor prognostic biomarker in invasive breast cancer.

The effect of environmental temperature on average daily gain in preweaned calves: A randomized controlled trial and Bayesian analysis (2022)
Journal Article
Hyde, R. M., Green, M. J., Hudson, C., & Down, P. M. (2022). The effect of environmental temperature on average daily gain in preweaned calves: A randomized controlled trial and Bayesian analysis. Journal of Dairy Science, 105(4), 3430-3439. https://doi.org/10.3168/jds.2021-21199

Neonatal calves are relatively susceptible to heat loss, and previous research suggests that reduced environmental temperatures are associated with reduced average daily gain (ADG) during the preweaning phase. Current methods of mitigating negative e... Read More about The effect of environmental temperature on average daily gain in preweaned calves: A randomized controlled trial and Bayesian analysis.

A Simple Whole-Plasmid PCR Method to Construct High-Diversity Synthetic Phage Display Libraries (2022)
Journal Article
Tsoumpeli, M. T., Gray, A., Parsons, A. L., Spiliotopoulos, A., Owen, J. P., Bishop, K., …Gough, K. C. (2022). A Simple Whole-Plasmid PCR Method to Construct High-Diversity Synthetic Phage Display Libraries. Molecular Biotechnology, 64, 791-803. https://doi.org/10.1007/s12033-021-00442-4

Phage display technology utilises peptide and antibody libraries with very high diversities to select ligands with specific binding properties. The production of such libraries can be labour intensive and technically challenging and whilst there are... Read More about A Simple Whole-Plasmid PCR Method to Construct High-Diversity Synthetic Phage Display Libraries.

Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures (2022)
Journal Article
Lea, R. G., Mandon-Pépin, B., Loup, B., Poumerol, E., Jouneau, L., Egbowon, B. F., …Sinclair, K. D. (2022). Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures. Reproduction, 163(2), 119-131. https://doi.org/10.1530/REP-21-0235

Exposure of the fetal testis to numerous individual environmental chemicals (ECs) is frequently associated with dysregulated development, leading to impaired adult reproductive competence. However, 'real-life' exposure involves complex mixtures of EC... Read More about Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures.

Endothelial Cell RNA-Seq Data: Differential Expression and Functional Enrichment Analyses to Study Phenotypic Switching (2022)
Book Chapter
Pinel, G. D., Horder, J. L., King, J. R., McIntyre, A., Mongan, N. P., López, G. G., & Benest, A. V. (2022). Endothelial Cell RNA-Seq Data: Differential Expression and Functional Enrichment Analyses to Study Phenotypic Switching. In A. V. Benest (Ed.), Angiogenesis: Methods and Protocol (369-426). Springer. https://doi.org/10.1007/978-1-0716-2059-5_29

RNA-seq is a common approach used to explore gene expression data between experimental conditions or cell types and ultimately leads to information that can shed light on the biological processes involved and inform further hypotheses. While the prot... Read More about Endothelial Cell RNA-Seq Data: Differential Expression and Functional Enrichment Analyses to Study Phenotypic Switching.

Top 5 Tips for Reading a Veterinary Scientific Study (2022)
Journal Article
Arlt, S. P., & Brennan, M. L. (2022). Top 5 Tips for Reading a Veterinary Scientific Study. Clinician's brief,

Results from scientific research can help provide optimal care. Daily decisions should lead to effective diagnostic procedures and therapeutic interventions with optimal risk:benefit ratios. It is therefore important to be able to select and evaluate... Read More about Top 5 Tips for Reading a Veterinary Scientific Study.

Cattle farmer psychosocial profiles and their association with control strategies for bovine viral diarrhea (2022)
Journal Article
Prosser, N. S., Green, M. J., Ferguson, E., Tildesley, M. J., Hill, E. M., Keeling, M. J., & Kaler, J. (2022). Cattle farmer psychosocial profiles and their association with control strategies for bovine viral diarrhea. Journal of Dairy Science, 105(4), 3559-3573. https://doi.org/10.3168/jds.2021-21386

Bovine viral diarrhea (BVD) is endemic in the United Kingdom and causes major economic losses. Control is largely voluntary for individual farmers and is likely to be influenced by psychosocial factors, such as altruism, trust, and psychological prox... Read More about Cattle farmer psychosocial profiles and their association with control strategies for bovine viral diarrhea.

Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China (2022)
Journal Article
Wang, W., Hu, Y., Baker, M., Dottorini, T., Li, H., Dong, Y., …Li, F. (2022). Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China. Journal of Antimicrobial Chemotherapy, 77(4), 903-909. https://doi.org/10.1093/jac/dkab500

Background Staphylococcal cassette chromosome mec (SCCmec) elements are highly diverse and have been classified into 14 types. Novel SCCmec variants have been frequently detected from humans and animals but rarely from food. Objectives To charac... Read More about Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China.

Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search (2022)
Journal Article
Fairbanks, E. L., Brennan, M. L., Mertens, P. P. C., Tildesley, M. J., & Daly, J. M. (2022). Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search. Transboundary and Emerging Diseases, 69(4), e671-e681. https://doi.org/10.1111/tbed.14420

African horse sickness (AHS) is a vector-borne disease transmitted by Culicoides spp., endemic to sub-Saharan Africa. There have been many examples of historic and recent outbreaks in the Middle East, Asia and Europe. However, not much is known about... Read More about Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search.