All Outputs (166)

Modelling livestock infectious disease control policy under differing social perspectives on vaccination behaviour (2022)
Journal Article

The spread of infection amongst livestock depends not only on the traits of the pathogen and the livestock themselves, but also on the veterinary health behaviours of farmers and how this impacts their implementation of disease control measures. Cont... Read More about Modelling livestock infectious disease control policy under differing social perspectives on vaccination behaviour.

Modelling livestock infectious disease control policy under differing social perspectives on vaccination behaviour. (2022)
Journal Article

Background: The spread of infection amongst livestock depends not only on the traits of the pathogen and the livestock themselves, but also on the behavioural characteristics of farmers and how that impacts the implementation of livestock disease con... Read More about Modelling livestock infectious disease control policy under differing social perspectives on vaccination behaviour..

Stability selection for mixed effect models with large numbers of predictor variables: A simulation study (2022)
Journal Article

Covariate selection when the number of available variables is large relative to the number of observations is problematic in epidemiology and remains the focus of continued research. Whilst a variety of statistical methods have been developed to atte... Read More about Stability selection for mixed effect models with large numbers of predictor variables: A simulation study.

Levels of Evidence, Quality Assessment, and Risk of Bias: Evaluating the Internal Validity of Primary Research (2022)
Journal Article

Clinical decisions in human and veterinary medicine should be based on the best available evidence. The results of primary research are an important component of that evidence base. Regardless of whether assessing studies for clinical case management... Read More about Levels of Evidence, Quality Assessment, and Risk of Bias: Evaluating the Internal Validity of Primary Research.

Does having an intravenous catheter in situ for a longer time increase dogs' risk of developing phlebitis? (2022)
Journal Article

A Prospective Cohort Study Investigating the Behavioural Development of Bitches in a Guide Dog Training Programme Neutered Prepubertally or Post-Pubertally (2022)
Journal Article

There are few studies that investigate the effect of neutering bitches before or after puberty. The majority of current literature examining the impact of the timing of neutering on health and behaviour has used age rather than the onset of puberty a... Read More about A Prospective Cohort Study Investigating the Behavioural Development of Bitches in a Guide Dog Training Programme Neutered Prepubertally or Post-Pubertally.

The impact of glutaraldehyde based footbaths on Dichelobacter nodosus prevalence and the antimicrobial resistant community of the ovine interdigital skin (2022)
Journal Article

Ovine footrot, is a highly contagious polymicrobial bacterial infection, primarily caused by Dichelobacter nodosus. Preventative bactericidal footbaths are commonly used in the sheep industry to reduce the spread of bacteria. However, their effect on... Read More about The impact of glutaraldehyde based footbaths on Dichelobacter nodosus prevalence and the antimicrobial resistant community of the ovine interdigital skin.

Diagnosis and Management of Acanthamoeba Keratitis: A Continental Approach (2022)
Journal Article

Acanthamoeba keratitis (AK) is a potentially blinding infection caused by protozoa found worldwide. The topical application of biguanides and diamidines is the most common anti-amoebic treatment for AK. In this study, we hypothesized that geographica... Read More about Diagnosis and Management of Acanthamoeba Keratitis: A Continental Approach.

Welfare indicators for stunning versus non‐stunning slaughter in sheep and cattle: A scoping review (2022)
Journal Article

Background: While most cattle and sheep in the United Kingdom are stunned before slaughter, non-stun methods are permitted to supply meat to specific consumers. This study aimed to identify the existing literature that compared animal welfare indicat... Read More about Welfare indicators for stunning versus non‐stunning slaughter in sheep and cattle: A scoping review.

Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals (2022)
Journal Article

Avian influenza virus (AIV) can evolve multiple strategies to combat host antiviral defenses and establish efficient infectivity in mammals, including humans. H9N2 AIV and its reassortants (such as H5N6 and H7N9 viruses) pose an increasing threat to... Read More about Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals.

Working with farmers to optimise mineral balance in grazing sheep (2022)
Journal Article

Background: Trace mineral analysis is a useful but underused tool in ruminant livestock production. Routine on-farm use of diagnostic techniques can help to ensure animal nutritional requirements are being met through improved supplementation choices... Read More about Working with farmers to optimise mineral balance in grazing sheep.

Differential and defective transcription of koala retrovirus indicates the complexity of host and virus evolution (2022)
Journal Article

Koala retrovirus (KoRV) is unique amongst endogenous (inherited) retroviruses in that its incorporation to the host genome is still active, providing an opportunity to study what drives this fundamental process in vertebrate genome evolution. Animals... Read More about Differential and defective transcription of koala retrovirus indicates the complexity of host and virus evolution.

An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation (2022)
Journal Article

Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine stu... Read More about An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation.

Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts (2022)
Journal Article

The chemotherapy resistance of esophageal adenocarcinomas (EACs) is underpinned by cancer cell extrinsic mechanisms of the tumor microenvironment (TME). We demonstrate that, by targeting the tumor-promoting functions of the predominant TME cell type,... Read More about Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts.

Failure to detect Schmallenberg Virus in ram semen in the UK (2016-2018) (2022)
Journal Article

Background Schmallenberg virus is a midge borne arbovirus that first emerged in the European ruminant population in 2011 and has since settled to an endemic pattern of disease The impacts of trade restrictions on genetic products (semen, embryos) f... Read More about Failure to detect Schmallenberg Virus in ram semen in the UK (2016-2018).

Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs (2022)
Journal Article

Current declines in male reproductive health may, in part, be driven by anthropogenic environmental chemical (EC) exposure. Using a biosolids treated pasture (BTP) sheep model, this study examined the effects of gestational exposure to a translationa... Read More about Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs.

Scoping review of end-of-life decision-making models used in dogs, cats and equids (2022)
Journal Article

Background: End-of-life decisions for companion animals can be stressful for veterinarians and owners, and when delayed result in poor animal welfare. Delayed euthanasia has been identified as a particularly prominent issue for horses. This scoping r... Read More about Scoping review of end-of-life decision-making models used in dogs, cats and equids.

Analysis of phenotype-genotype associations using genomic informational field theory (GIFT) (2022)
Journal Article

We show how field- and information theory can be used to quantify the relationship between genotype and phenotype in cases where phenotype is a continuous variable. Given a sample population of phenotype measurements, from various known genotypes, we... Read More about Analysis of phenotype-genotype associations using genomic informational field theory (GIFT).

Equine Stress: Neuroendocrine Physiology and Pathophysiology (2022)
Book Chapter

Personality and predictability in farmed calves using movement and space-use behaviours quantified by ultra-wideband sensors (2022)
Journal Article

Individuals within a population often show consistent between individual differences in their average behavioural expression (personality), and consistent differences in their within-individual variability of behaviour around the mean (predictability... Read More about Personality and predictability in farmed calves using movement and space-use behaviours quantified by ultra-wideband sensors.