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“Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence (2020)
Journal Article
Pascall, D. J., Nomikou, K., Bréard, E., Zientara, S., da Silva Filipe, A., Hoffmann, B., …Palmarini, M. (2020). “Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence. PLoS Biology, 18(4), Article e300067. https://doi.org/10.1371/journal.pbio.3000673

© 2020 Pascall et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr... Read More about “Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence.

Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii (2020)
Journal Article
Nie, L., Liang, Q., Du, R., Elsheikha, H. M., Han, N., Li, F., & Zhu, X. (2020). Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii. Frontiers in Microbiology, 11, Article 776. https://doi.org/10.3389/fmicb.2020.00776

Lysine malonylation (Kmal) is a new post-translational modification (PTM), which has been reported in several prokaryotic and eukaryotic species. Although Kmal can regulate many and diverse biological processes in various organisms, knowledge about t... Read More about Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii.

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury (2020)
Journal Article
Kim, J. Y., Bai, Y., Jayne, L. A., Hector, R. D., Persaud, A. K., Ong, S. S., …Pabla, N. S. (2020). A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury. Nature Communications, 11(1), Article 1924. https://doi.org/10.1038/s41467-020-15638-6

© 2020, The Author(s). Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, elect... Read More about A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening (2020)
Journal Article
Solovyeva, V. V., Kitaeva, K. V., Rutland, C. S., & Rizvanov, A. A. (2020). Cell Culture Based in vitro Test Systems for Anticancer Drug Screening. Frontiers in Bioengineering and Biotechnology, 8, Article 322. https://doi.org/10.3389/fbioe.2020.00322

The development of new high-tech systems for screening anticancer drugs is one of the main problems of preclinical screening. Poor correlation between preclinical in vitro and in vivo data with clinical trials remains a major concern. The choice of t... Read More about Cell Culture Based in vitro Test Systems for Anticancer Drug Screening.

Prognostic factors for short‐term survival of dogs that experience postattenuation seizures after surgical correction of single congenital extrahepatic portosystemic shunts: 93 cases (2005‐2018) (2020)
Journal Article
Mullins, R. A., Sanchez Villamil, C., Selmic, L. E., Tivers, M. S., Case, J. B., Singh, A., …Kirby, B. M. (2020). Prognostic factors for short‐term survival of dogs that experience postattenuation seizures after surgical correction of single congenital extrahepatic portosystemic shunts: 93 cases (2005‐2018). Veterinary Surgery, 49(5), 958-970. https://doi.org/10.1111/vsu.13422

© 2020 The American College of Veterinary Surgeons Objective: To identify prognostic factors for short-term survival of dogs that experience seizures within 7 days after surgical correction of single congenital extrahepatic portosystemic shunts (cEHP... Read More about Prognostic factors for short‐term survival of dogs that experience postattenuation seizures after surgical correction of single congenital extrahepatic portosystemic shunts: 93 cases (2005‐2018).

Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species (2020)
Journal Article
Chappell, J. G., Tsoleridis, T., Onianwa, O., Drake, G., Ashpole, I., Dobbs, P., …McClure, C. P. (2020). Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species. Viruses, 12(4), Article 454. https://doi.org/10.3390/v12040454

©2020 by the authors. Licensee MDPI, Basel, Switzerland. Orthohantaviruses are globally distributed viruses, associated with rodents and other small mammals. However, data on the circulation of orthohantaviruses within the UK, particularly the UK-end... Read More about Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species.

iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during toxoplasma gondii infection in swine (2020)
Journal Article
He, J., Ma, J., Wang, J., Zhang, F., Li, J., Zhai, B., …Zhu, X. (2020). iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during toxoplasma gondii infection in swine. Microorganisms, 8(4), Article 518. https://doi.org/10.3390/microorganisms8040518

Toxoplasma gondii is a leading cause of foodborne illness and consumption of undercooked pig meat is a major risk factor for acquiring toxoplasmosis, which causes a substantial burden on society. Here, we used isobaric tags for relative and absolute... Read More about iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during toxoplasma gondii infection in swine.

Influencing Change: When “Best Practice” Changes and the Prototypical Good Farmer Turns Bad (2020)
Journal Article
Green, L., Kaler, J., Liu, N., & Ferguson, E. (2020). Influencing Change: When “Best Practice” Changes and the Prototypical Good Farmer Turns Bad. Frontiers in Veterinary Science, 7, Article 161. https://doi.org/10.3389/fvets.2020.00161

Twenty-nine farmers with a flock prevalence of lameness >5% were visited in 2013. They participated in a facilitated discussion on treatment of footrot, and evidence-based new “best practice.” One year later, farmers were revisited and management and... Read More about Influencing Change: When “Best Practice” Changes and the Prototypical Good Farmer Turns Bad.

Crystal structure of the C-terminal domain of DENR (2020)
Journal Article
Lomakin, I. B., De, S., Wang, J., Borkar, A. N., & Steitz, T. A. (2020). Crystal structure of the C-terminal domain of DENR. Computational and Structural Biotechnology Journal, 18, 696-704. https://doi.org/10.1016/j.csbj.2020.03.009

© 2020 The Authors The density regulated protein (DENR) forms a stable heterodimer with malignant T-cell-amplified sequence 1 (MCT-1). DENR-MCT-1 heterodimer then participates in regulation of non-canonical translation initiation and ribosomal recycl... Read More about Crystal structure of the C-terminal domain of DENR.

Significant transcriptional changes in mature daughter Varroa destructor mites during infestation of different developmental stages of honeybees (2020)
Journal Article
Tu, Y., Wu, J., Elsheikha, H. M., Getachew, A., Zhou, C., Zhou, H., & Xu, S. (2020). Significant transcriptional changes in mature daughter Varroa destructor mites during infestation of different developmental stages of honeybees. Pest Management Science, 76(8), 2736-2745. https://doi.org/10.1002/ps.5821

Background: Varroa destructor is considered a major cause of honeybee (Apis mellifera) colony losses worldwide. Although V. destructor mites exhibit preference behavior for certain honeybee lifecycle stages, the mechanism underlying host finding and... Read More about Significant transcriptional changes in mature daughter Varroa destructor mites during infestation of different developmental stages of honeybees.

Pathological Findings in Koala Retrovirus-positive Koalas (Phascolarctos cinereus) from Northern and Southern Australia (2020)
Journal Article
Fabijan, J., Sarker, N., Speight, N., Owen, H., Meers, J., Simmons, G., …Trott, D. J. (2020). Pathological Findings in Koala Retrovirus-positive Koalas (Phascolarctos cinereus) from Northern and Southern Australia. Journal of Comparative Pathology, 176, 50-66. https://doi.org/10.1016/j.jcpa.2020.02.003

© 2020 Elsevier Ltd Koala retrovirus (KoRV) infection shows differences in prevalence and load between northern and southern Australian koala populations; however, the effect of this on diseases such as lymphoma and chlamydial disease is unclear. Thi... Read More about Pathological Findings in Koala Retrovirus-positive Koalas (Phascolarctos cinereus) from Northern and Southern Australia.

Molecular detection of arthropod-borne pathogens in Eurasian badgers (Meles meles) from the United Kingdom (2020)
Journal Article
Guardone, L., Ebani, V. V., Verin, R., Nardoni, S., Consolazione, A., Bennett, M., & Mancianti, F. (2020). Molecular detection of arthropod-borne pathogens in Eurasian badgers (Meles meles) from the United Kingdom. Animals, 10(3), Article 446. https://doi.org/10.3390/ani10030446

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Arthropod-borne diseases (ABD) are of increasing interest in veterinary and public health. Eurasian badgers (Meles meles) are known to harbor a wide range of pathogens, but information on thei... Read More about Molecular detection of arthropod-borne pathogens in Eurasian badgers (Meles meles) from the United Kingdom.

Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism (2020)
Journal Article
Boag, A. M., Short, A., Kennedy, L. J., Syme, H., Graham, P. A., & Catchpole, B. (2020). Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism. Canine Medicine and Genetics, 7, Article 2. https://doi.org/10.1186/s40575-020-0081-4

Background Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison’s disease in humans. Several dog breeds are overrepresented in the disease population, suggesting t... Read More about Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism.

Update on caseous lymphadenitis in sheep (2020)
Journal Article
Gascoigne, E., Ogden, N., Lovatt, F., & Davies, P. (2020). Update on caseous lymphadenitis in sheep. In Practice, 42(2), 105-114. https://doi.org/10.1136/inp.m455

Background: Caseous lymphadenitis (CLA), caused by the gram-positive bacteria Corynebacterium pseudotuberculosis, has been present in Great Britain since the 1980s and is now considered endemic. CLA is considered to be an iceberg disease; that is, it... Read More about Update on caseous lymphadenitis in sheep.

RHΔgra17Δnpt1 strain of Toxoplasma gondii elicits protective immunity against acute, chronic and congenital toxoplasmosis in mice (2020)
Journal Article
Sun, L., Liang, Q., Elsheikha, H. M., Cao, X., Nie, L., Li, T., …Wang, J. (2020). RHΔgra17Δnpt1 strain of Toxoplasma gondii elicits protective immunity against acute, chronic and congenital toxoplasmosis in mice. Microorganisms, 8(3), Article 352. https://doi.org/10.3390/microorganisms8030352

In the present study, a dense granule protein 17 (gra17) and novel putative transporter (npt1) double deletion mutant of Toxoplasma gondii RH strain was engineered. The protective efficacy of vaccination using RHΔgra17Δnpt1 tachyzoites against acute,... Read More about RHΔgra17Δnpt1 strain of Toxoplasma gondii elicits protective immunity against acute, chronic and congenital toxoplasmosis in mice.

Single dose epidural methylprednisolone as a treatment and predictor of outcome following subsequent decompressive surgery in degenerative lumbosacral stenosis with foraminal stenosis (2020)
Journal Article
Gomes, S. A., Lowrie, M., & Targett, M. (2020). Single dose epidural methylprednisolone as a treatment and predictor of outcome following subsequent decompressive surgery in degenerative lumbosacral stenosis with foraminal stenosis. Veterinary Journal, 257, Article 105451. https://doi.org/10.1016/j.tvjl.2020.105451

© 2020 Elsevier Ltd Alternative treatments to surgery in canine degenerative lumbosacral stenosis (DLSS) remain limited and reliable predictors of outcome are lacking. The aims of this clinical trial were threefold: to assess the usefulness of single... Read More about Single dose epidural methylprednisolone as a treatment and predictor of outcome following subsequent decompressive surgery in degenerative lumbosacral stenosis with foraminal stenosis.

Renal accumulation of prooxidant mineral elements and CKD in domestic cats (2020)
Journal Article
Alborough, R., Grau-Roma, L., de Brot, S., Hantke, G., Vazquez, S., & Gardner, D. S. (2020). Renal accumulation of prooxidant mineral elements and CKD in domestic cats. Scientific Reports, 10(1), Article 3160. https://doi.org/10.1038/s41598-020-59876-6

Felids have a high incidence of chronic kidney disease (CKD), for which the most common renal lesion is chronic interstitial nephritis (CIN). CIN can be induced by tissue oxidative stress, which is determined by the cellular balance of pro- and anti-... Read More about Renal accumulation of prooxidant mineral elements and CKD in domestic cats.

Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers (2020)
Journal Article
Janssen, E. A., Ogden, A., Bhattarai, S., Sahoo, B., Mongan, N. P., Alsaleem, M., …Aneja, R. (2020). Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers. Scientific Reports, 10(1), Article 3009. https://doi.org/10.1038/s41598-020-59514-1

© 2020, The Author(s). Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (HER3) have been investigated as triple-negative breast cancer (TNBC) biomarkers. Reduced EGFR levels can be compensated by increases in HER3;... Read More about Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers.

Transcriptional changes in Toxoplasma gondii in response to treatment with monensin (2020)
Journal Article
Zhai, B., He, J., Elsheikha, H. M., Li, J., Zhu, X., & Yang, X. (2020). Transcriptional changes in Toxoplasma gondii in response to treatment with monensin. Parasites and Vectors, 13, Article 84. https://doi.org/10.1186/s13071-020-3970-1

Background: Infection with the apicomplexan protozoan parasite T. gondii can cause severe and potentially fatal cerebral and ocular disease, especially in immunocompromised individuals. The anticoccidial ionophore drug monensin has been shown to have... Read More about Transcriptional changes in Toxoplasma gondii in response to treatment with monensin.