All Outputs (1330)

Novel holistic pharmacokinetic model applied to plasma and urine concentrations of 2,5‐dihydroxybenzene sulphonate following administrations of calcium dobesilate and etamsylate to exercised horses (2023)
Journal Article
Paine, S. W., Harding, C., Waller, C. C., Zemenova, J., Viljanto, M., Habershon Butcher, J., & Hincks, P. R. (2023). Novel holistic pharmacokinetic model applied to plasma and urine concentrations of 2,5‐dihydroxybenzene sulphonate following administrations of calcium dobesilate and etamsylate to exercised horses. Journal of Veterinary Pharmacology and Therapeutics, 46(6), 365-374. https://doi.org/10.1111/jvp.13387

AbstractCalcium dobesilate (CD) is a synthetic venoactive drug used in veterinary medicine to treat equine navicular disease. Etamsylate is a haemostatic agent used in horses for the treatment of exercise‐induced pulmonary haemorrhage. Both etamsylat... Read More about Novel holistic pharmacokinetic model applied to plasma and urine concentrations of 2,5‐dihydroxybenzene sulphonate following administrations of calcium dobesilate and etamsylate to exercised horses.

Repeat patient testing-quality control with canine samples shows promise as an alternative to commercial quality control material for a network of 4 Sysmex XT2000iV hematology analyzers (2023)
Journal Article
Daly, S., Graham, P., & Freeman, K. P. (2024). Repeat patient testing-quality control with canine samples shows promise as an alternative to commercial quality control material for a network of 4 Sysmex XT2000iV hematology analyzers. Veterinary Clinical Pathology, 53(S1), 39-47. https://doi.org/10.1111/vcp.13211

Background Repeat patient testing-quality control (RPT-QC) uses retained patient samples as an alternative to commercial quality control material (QCM). We elected to calculate and validate RPT-QC limits for red blood cell count (RBC), hemoglobin (H... Read More about Repeat patient testing-quality control with canine samples shows promise as an alternative to commercial quality control material for a network of 4 Sysmex XT2000iV hematology analyzers.

Encapsulated papillary carcinoma of the breast: does it have a native basement membrane? (2023)
Journal Article
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. (2023). Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?. Histopathology, 83(3), 376-393. https://doi.org/10.1111/his.14939

Background Encapsulated papillary carcinoma (EPC) is surrounded by a thick fibrous capsule-like structure, which is interpreted as a thickened basement membrane (BM). This study aimed to describe the geometric characteristics of the EPC capsule and... Read More about Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?.

Global prevalence and factors affecting the level of Cryptosporidium contamination in soil: A systematic review, meta-analysis, and meta-regression (2023)
Journal Article
Zuo, M., Li, X., Xu, R., Sun, W., Elsheikha, H. M., & Cong, W. (2023). Global prevalence and factors affecting the level of Cryptosporidium contamination in soil: A systematic review, meta-analysis, and meta-regression. Science of the Total Environment, 891, Article 164286. https://doi.org/10.1016/j.scitotenv.2023.164286

Soil contamination with Cryptosporidium is a serious environmental and public health concern. In this systematic review and meta-analysis we estimated the global prevalence of Cryptosporidium contamination in soil and evaluated its association with c... Read More about Global prevalence and factors affecting the level of Cryptosporidium contamination in soil: A systematic review, meta-analysis, and meta-regression.

Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer (2023)
Journal Article
Lashen, A. G., Toss, M. S., Wootton, L., Green, A. R., Mongan, N. P., Madhusudan, S., & Rakha, E. (2023). Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer. Histopathology, 83(3), 414-425. https://doi.org/10.1111/his.14960

Background: Polo-like kinase-1 (PLK1) plays a crucial role in cell cycle progression,and it is considered a potential therapeutic target in many cancers. Although the role of PLK1 is well established in triple negative breast cancer (TNBC) as an onco... Read More about Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer.

Predicting bioactivity of antibiotic metabolites by molecular docking and dynamics (2023)
Journal Article
Chio, H., Guest, E. E., Hobman, J. L., Dottorini, T., Hirst, J. D., & Stekel, D. J. (2023). Predicting bioactivity of antibiotic metabolites by molecular docking and dynamics. Journal of Molecular Graphics and Modelling, 123, Article 108508. https://doi.org/10.1016/j.jmgm.2023.108508

Antibiotics enter the environment through waste streams, where they can exert selective pressure for antimicrobial resistance in bacteria. However, many antibiotics are excreted as partly metabolized forms, or can be subject to partial breakdown in w... Read More about Predicting bioactivity of antibiotic metabolites by molecular docking and dynamics.

Uncovering the Underlying Mechanisms Blocking Replication of Bluetongue Virus Serotype 26 (BTV-26) in Culicoides Cells (2023)
Journal Article
Monsion, B., Mohd Jaafar, F., Mertens, P. P., & Attoui, H. (2023). Uncovering the Underlying Mechanisms Blocking Replication of Bluetongue Virus Serotype 26 (BTV-26) in Culicoides Cells. Biomolecules, 13(6), Article 878. https://doi.org/10.3390/biom13060878

At least 12 serotypes of ‘atypical’ bluetongue virus (BTV-25 to BTV-36) have been identified to date. These atypical serotypes fail to infect/replicate in Culicoides-derived cell lines and/or adult Culicoides vectors and hence can no longer be transm... Read More about Uncovering the Underlying Mechanisms Blocking Replication of Bluetongue Virus Serotype 26 (BTV-26) in Culicoides Cells.

Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases (2023)
Journal Article
Martín‐Ambrosio Francés, M., Seth, M., Sharman, M., Pollard, D., Ortiz, A. L., Miller, R., …Selgas, A. G. (2023). Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases. Veterinary Medicine and Science, 9(4), 1495-1507. https://doi.org/10.1002/vms3.1091

Background: Thrombocytopenia is a common laboratory abnormality in dogs, and numerous diseases have been associated with its development. Estimates for the sensitivity and specificity of the degree of reduction of platelet concentration for the diagn... Read More about Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases.

An observational study of ear-tagged calf mortality (1 to 100 days) on Irish dairy farms and associations between biosecurity practices and calf mortality on farms participating in a Johne's disease control program (2023)
Journal Article
McAloon, C. G., Tratalos, J. A., O'Grady, L., Green, M. J., Gavey, L., Graham, D., …Mee, J. F. (2023). An observational study of ear-tagged calf mortality (1 to 100 days) on Irish dairy farms and associations between biosecurity practices and calf mortality on farms participating in a Johne's disease control program. Journal of Dairy Science, 106(7), 4966-4977. https://doi.org/10.3168/jds.2022-22519

Postnatal mortality among replacement stock has a detrimental effect on the social, economic, and environmental sustainability of dairy production. Calf mortality rates vary between countries and show differences in temporal trends; most, however, ar... Read More about An observational study of ear-tagged calf mortality (1 to 100 days) on Irish dairy farms and associations between biosecurity practices and calf mortality on farms participating in a Johne's disease control program.

Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi (2023)
Journal Article
Mikolajek, H., Sanchez-Weatherby, J., Sandy, J., Gildea, R. J., Campeotto, I., Cheruvara, H., …Hough, M. A. (2023). Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi. IUCrJ, 10(4), 420-429. https://doi.org/10.1107/s2052252523003810

The utility of X-ray crystal structures determined under ambient-temperature conditions is becoming increasingly recognized. Such experiments can allow protein dynamics to be characterized and are particularly well suited to challenging protein targe... Read More about Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi.

Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood (2023)
Journal Article
Elcombe, C. S., Monteiro, A., Ghasemzadeh-Hasankolaei, M., Padmanabhan, V., Lea, R., Sinclair, K. D., …Bellingham, M. (2023). Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood. Environmental Toxicology and Pharmacology, 100, Article 104152. https://doi.org/10.1016/j.etap.2023.104152

Environmental chemical (EC) exposure may be impacting male reproductive health. The translationally relevant biosolids treated pasture (BTP) sheep model was used to investigate gestational low-level EC mixture exposure on the testes of F1 male offspr... Read More about Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood.

RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance (2023)
Journal Article
Stockdale, S. R., Blanchard, A. M., Nayak, A., Husain, A., Nashine, R., Dudani, H., …Monaghan, T. M. (2023). RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance. The Lancet Regional Health – Southeast Asia, 14, Article 100205. https://doi.org/10.1016/j.lansea.2023.100205

Background: The COVID-19 pandemic showcased the power of genomic sequencing to tackle the emergence and spread of infectious diseases. However, metagenomic sequencing of total microbial RNAs in wastewater has the potential to assess multiple infectio... Read More about RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance.

Herd health: approach to assessing fertility data quality (2023)
Journal Article
Reynolds, J., & Hudson, C. (2023). Herd health: approach to assessing fertility data quality. In Practice, 45(4), 222-230. https://doi.org/10.1002/inpr.311

Background: Farm animal veterinarians are increasingly using routinely collected farm data to assess performance and enable implementation of preventive management changes on farm. Furthermore, the significance of data collection and data management... Read More about Herd health: approach to assessing fertility data quality.

The use of theories, models, and frameworks to inform the uptake of evidence-based practices in veterinary medicine - a scoping review (2023)
Journal Article
Reyneke, R. A., Richens, I. F., Buchanan, H., Bethan Davies, E., Sorrell, C., Ashmore, A., & Brennan, M. L. (2023). The use of theories, models, and frameworks to inform the uptake of evidence-based practices in veterinary medicine - a scoping review. Preventive Veterinary Medicine, 216, Article 105928. https://doi.org/10.1016/j.prevetmed.2023.105928

Evidence-based practices (EBPs) provide strategies to improve the health, welfare and productivity of animal species. However, ensuring implementation and uptake into routine practice of these EBPs is often challenging. In human health research, one... Read More about The use of theories, models, and frameworks to inform the uptake of evidence-based practices in veterinary medicine - a scoping review.

Targeting DNA damage repair precision medicine strategies in cancer (2023)
Journal Article
Brownlie, J., Kulkarni, S., Algethami, M., Jeyapalan, J. N., Mongan, N. P., Rakha, E. A., & Madhusudan, S. (2023). Targeting DNA damage repair precision medicine strategies in cancer. Current Opinion in Pharmacology, 70, Article 102381. https://doi.org/10.1016/j.coph.2023.102381

DNA repair targeted therapeutics is a promising precision medicine strategy in cancer. The development and clinical use of PARP inhibitors has transformed lives for many patients with BRCA germline deficient breast and ovarian cancer as well as plati... Read More about Targeting DNA damage repair precision medicine strategies in cancer.

Editorial: Community series - innovative approaches in diagnosis of emerging/re-emerging infectious diseases, volume II (2023)
Journal Article
Foster, T., & Khaiboullina, S. (2023). Editorial: Community series - innovative approaches in diagnosis of emerging/re-emerging infectious diseases, volume II. Frontiers in Microbiology, 14, Article 1193841. https://doi.org/10.3389/fmicb.2023.1193841

Editorial on the Research Topic: Community series - innovative approaches in diagnosis of emerging/re-emerging infectious diseases, volume II

Isolation and Characterization of a Novel Phage Collection against Avian-Pathogenic Escherichia coli (2023)
Journal Article
Nicolas, M., Trotereau, A., Culot, A., Moodley, A., Atterbury, R., Wagemans, J., …Schouler, C. (2023). Isolation and Characterization of a Novel Phage Collection against Avian-Pathogenic Escherichia coli. Microbiology Spectrum, 11(3), Article e04296-22. https://doi.org/10.1128/spectrum.04296-22

The increase in antibiotic-resistant avian-pathogenic Escherichia coli (APEC), the causative agent of colibacillosis in poultry, warrants urgent research and the development of alternative therapies. This study describes the isolation and characteriz... Read More about Isolation and Characterization of a Novel Phage Collection against Avian-Pathogenic Escherichia coli.

Temporal trends in equine sperm progressive motility: a systematic review and meta-regression (2023)
Journal Article
Harris, I. T., Maddock, C., Farnworth, M., Nankervis, K., Perrett, J., Pyatt, A. Z., & Blanchard, R. N. (2023). Temporal trends in equine sperm progressive motility: a systematic review and meta-regression. Reproduction, 165(6), M1–M10. https://doi.org/10.1530/REP-22-0490

In brief: Adverse trends in reproductive function are a concern in humans, companion, livestock, and wildlife species. This study indicates that equine populations are at risk of a comparable decline in sperm progressive motility. Abstract: There is... Read More about Temporal trends in equine sperm progressive motility: a systematic review and meta-regression.

The antioxidant protein glutaredoxin 1 is essential for oxidative stress response and pathogenicity of Toxoplasma gondii (2023)
Journal Article
Li, T., Zhao, D., Liang, Q., Elsheikha, H. M., Wang, M., Sun, L., …Wang, J. (2023). The antioxidant protein glutaredoxin 1 is essential for oxidative stress response and pathogenicity of Toxoplasma gondii. The FASEB Journal, 37(6), Article e22932. https://doi.org/10.1096/fj.202201275r

Glutaredoxins (Grxs) are ubiquitous antioxidant proteins involved in many molecular processes to protect cells against oxidative damage. Here, we study the roles of Grxs in the pathogenicity of Toxoplasma gondii. We show that Grxs are localized in th... Read More about The antioxidant protein glutaredoxin 1 is essential for oxidative stress response and pathogenicity of Toxoplasma gondii.

A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development (2023)
Journal Article
Moxon, R., Freeman, S. L., Payne, R., Godfrey-Hunt, J., Corr, S., & England, G. C. W. (2023). A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development. Animals, 13(9), Article 1431. https://doi.org/10.3390/ani13091431

No previous large prospective cohort studies have been identified that have investigated the impact of the surgical neutering of bitches before or after known puberty on their growth and physical development. This study was designed to examine the da... Read More about A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development.