All Outputs (1346)

A multistate modeling approach to investigate long-term effects of claw horn disruption lesions and early lesion development in dairy cows (2023)
Journal Article

Claw horn disruption lesions (CHDL) are a leading cause of lameness in dairy cattle, and the development, effect, and pathology of these lesions remains an open area of interest within dairy cattle health. Current literature typically attempts to mea... Read More about A multistate modeling approach to investigate long-term effects of claw horn disruption lesions and early lesion development in dairy cows.

Companion animal parasites: 10 years on (2023)
Journal Article

Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers (2023)
Journal Article

Replication Protein A (RPA), a heterotrimeric complex consisting of RPA1, 2, and 3 subunits, is a single-stranded DNA (ssDNA)-binding protein that is critically involved in replication, checkpoint regulation and DNA repair. Here we have evaluated RPA... Read More about Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers.

Modulation of long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression in the liver of Beagle dogs by Toxocara canis infection (2023)
Journal Article

Background Long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) play crucial roles in regulating various physiological and pathological processes. However, the role of lncRNAs and mRNAs in mediating the liver response during Toxocara canis infec... Read More about Modulation of long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression in the liver of Beagle dogs by Toxocara canis infection.

Longitudinal study of antimicrobial use patterns, vaccination and disease prevalence in British sheep flocks (2023)
Journal Article

Background: The aim of the study was to describe the longitudinal dynamics of antimicrobial use (AMU) on sheep farms and explore associations between AMU and management factors, vaccination strategies, reproductive performance and prevalence of lamen... Read More about Longitudinal study of antimicrobial use patterns, vaccination and disease prevalence in British sheep flocks.

Use of qualitative behavioural assessment to investigate affective states of housed dairy cows under different environmental conditions (2023)
Journal Article

In addition to the reduction of suboptimal welfare, there is now a need to provide farmed animals with positive opportunities to provide confidence that they have experienced a life worth living. Diversification of the environment through environment... Read More about Use of qualitative behavioural assessment to investigate affective states of housed dairy cows under different environmental conditions.

Topographic anatomy and vascularization of the glandula thyroidea in rats (2023)
Journal Article

Topographical anatomy and detailed measurements of the glandula thyroidea (thyroid gland) and the glandula parathyroidea (parathyroid gland) were determined in rats, with significant differences identified between the sexes. In the rats (N=10 male, 1... Read More about Topographic anatomy and vascularization of the glandula thyroidea in rats.

Serum 1H nuclear magnetic resonance–based metabolomics of sole lesion development in Holstein cows (2023)
Journal Article

Sole hemorrhage and sole ulcers, referred to as sole lesions, are important causes of lameness in dairy cattle. We aimed to compare the serum metabolome of dairy cows that developed sole lesions in early lactation with that of cows that remained unaf... Read More about Serum 1H nuclear magnetic resonance–based metabolomics of sole lesion development in Holstein cows.

Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation (2023)
Journal Article

Prion diseases are progressive neurodegenerative disorders with no effective therapeutics. The central event leading to the pathology in the diseases is the conversion of PrPC into PrPSc and its accumulation in the central nervous system. Previous st... Read More about Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation.

Zinc, Copper, and Manganese Homeostasis and Potential Trace Metal Accumulation in Dairy Cows: Longitudinal Study from Late Lactation to Subsequent Mid-Lactation (2023)
Journal Article

Background: Trace metals are supplemented in cattle to prevent nutrient deficiencies. Levels supplemented to mitigate worst-case basal supply and availability scenarios can, however, result in trace metal intakes far above the nutritional requirement... Read More about Zinc, Copper, and Manganese Homeostasis and Potential Trace Metal Accumulation in Dairy Cows: Longitudinal Study from Late Lactation to Subsequent Mid-Lactation.

The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode (2023)
Journal Article

N6-methyladenosine (m6A) in mRNA regulates almost every stage in the mRNA life cycle, and the development of methodologies for the high-throughput detection of methylated sites in mRNA using m6A-specific methylated RNA immunoprecipitation with next-g... Read More about The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode.

Associations between small ruminant lentivirus infection and total milk yield and somatic cell count in a dairy sheep flock (2023)
Journal Article

Background Small ruminant lentiviruses (SRLVs) are lentiviruses of sheep and goats, formerly known as maedi–visna (MV) in sheep and caprine encephalitis and arthritis in goats. In sheep, SRLVs commonly cause progressive pneumonia, wasting and indura... Read More about Associations between small ruminant lentivirus infection and total milk yield and somatic cell count in a dairy sheep flock.

Evaluation of an indwelling bolus equipped with a triaxial accelerometer for the characterisation of the diurnal pattern of bovine reticuloruminal contractions (2023)
Journal Article

This observational study aimed to describe the diurnal pattern of reticuloruminal contraction rate (RRCR) and the proportion of time spent ruminating by cattle, using two commercial devices equipped with triaxial accelerometers: an indwelling bolus (... Read More about Evaluation of an indwelling bolus equipped with a triaxial accelerometer for the characterisation of the diurnal pattern of bovine reticuloruminal contractions.

Familiarity, age, weaning and health status impact social proximity networks in dairy calves (2023)
Journal Article

Social network analysis in dairy calves has not been widely studied, with previous studies limited by the short study duration, and low number of animals and replicates. In this study, we investigated social proximity interactions of 79 Holstein–Frie... Read More about Familiarity, age, weaning and health status impact social proximity networks in dairy calves.

Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML (2023)
Journal Article

In vivo models of acute myeloid leukemia (AML) are low throughput, and standard liquid culture models fail to recapitulate the mechanical and biochemical properties of the extracellular matrix-rich protective bone marrow niche that contributes to dru... Read More about Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML.

NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma (2023)
Journal Article

In clear cell renal cell carcinoma (ccRCC), activation of hypoxic signaling induces NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) expression. Over 90% of ccRCCs exhibit overexpression of NDUFA4L2, which we previously showed... Read More about NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma.

Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells (2023)
Journal Article

Varanus niloticus is a lizard residing within the Varanidae family. To date no studies detailing its blood morphology and characteristics have been conducted. This study used histologically stained blood and bone marrow samples to visualize the cells... Read More about Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells.

Tilapia Lake Virus Vaccine Development: A Review on the Recent Advances (2023)
Journal Article

Tilapia tilapinevirus (or tilapia lake virus, TiLV) is a recently emerging virus associated with a novel disease affecting and decimating tilapia populations around the world. Since its initial identification, TiLV has been reported in 17 countries,... Read More about Tilapia Lake Virus Vaccine Development: A Review on the Recent Advances.

Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape (2023)
Journal Article

Understanding the links between environmental and wildlife elemental concentrations is key to help assess ecosystem functions and the potential effects of legacy pollutants. In this study, livers from 448 European badgers (Meles meles) collected acro... Read More about Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape.

The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up (2023)
Journal Article

Background: The routine assessment of progesterone receptor (PR) expression in breast cancer (BC) remains controversial. This study aimed to evaluate the role of PR expression in luminal BC, with emphasis on the definition of positivity and its progn... Read More about The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up.