All Outputs (138)

Comparison of computed tomographic angiography and intraoperative mesenteric portovenography for extrahepatic portosystemic shunts (2016)
Journal Article

Objectives Comparison of intra-operative mesenteric portovenography and computed tomographic angiography for the documentation of the portal vasculature in patients with single extrahepatic portosystemic shunts. Methods Retrospective study of pati... Read More about Comparison of computed tomographic angiography and intraoperative mesenteric portovenography for extrahepatic portosystemic shunts.

Modeling Enzyme Processivity Reveals that RNA-Seq Libraries Are Biased in Characteristic and Correctable Ways (2016)
Journal Article

© 2016 The Author(s) Experimental procedures for preparing RNA-seq and single-cell (sc) RNA-seq libraries are based on assumptions regarding their underlying enzymatic reactions. Here, we show that the fairness of these assumptions varies within libr... Read More about Modeling Enzyme Processivity Reveals that RNA-Seq Libraries Are Biased in Characteristic and Correctable Ways.

A New Metric for Quantifying the Relative Impact of Risk Factors on Loss of Working Life Illustrated in a Population of Working Dogs (2016)
Journal Article

In a resource-limited world, organisations attempting to reduce the impact of health or behaviour issues need to choose carefully how to allocate resources for the highest overall impact. However, such choices may not always be obvious. Which has the... Read More about A New Metric for Quantifying the Relative Impact of Risk Factors on Loss of Working Life Illustrated in a Population of Working Dogs.

Increased dietary protein in the second trimester of gestation increases live weight gain and carcass composition in weaner calves to 6 months of age (2016)
Journal Article

Genetically similar nulliparous Polled Hereford heifers from a closed pedigree herd were used to evaluate the effects of dietary protein during the first and second trimester of gestation upon fetal, placental and postnatal growth. Heifers were rando... Read More about Increased dietary protein in the second trimester of gestation increases live weight gain and carcass composition in weaner calves to 6 months of age.

Is gibbon ape leukaemia virus still a threat? (2016)
Journal Article

In the late 1960s and early 1970s, an outbreak of lymphoma and leukaemia in gibbons (Hylobatidae), attributed to the retrovirus gibbon ape leukaemia virus (GALV), was widely reported in the literature. The virus was identified in captive gibbon colon... Read More about Is gibbon ape leukaemia virus still a threat?.

A Trematode Parasite Derived Growth Factor Binds and Exerts Influences on Host Immune Functions via Host Cytokine Receptor Complexes (2016)
Journal Article

© 2016 Sulaiman et al. The trematode Fasciola hepatica is responsible for chronic zoonotic infection globally. Despite causing a potent T-helper 2 response, it is believed that potent immunomodulation is responsible for rendering this host reactive n... Read More about A Trematode Parasite Derived Growth Factor Binds and Exerts Influences on Host Immune Functions via Host Cytokine Receptor Complexes.

Genome sequence of Bluetongue virus serotype 17 isolated in Brazil in 2014 (2016)
Journal Article

The complete genome sequence of Bluetongue virus (BTV) serotype 17 strain 17/BRA/2014/73, isolated from a sheep in Brazil in 2014, is reported here. All segments clustered with western topotype strains and indicated reassortment events with other BTV... Read More about Genome sequence of Bluetongue virus serotype 17 isolated in Brazil in 2014.

Injection-site lesion prevalence and potential risk factors in UK beef cattle (2016)
Journal Article

Injectable veterinary medicinal products (VMPs) are widely used in cattle in the UK, and in particular vaccines are often used on large numbers of animals in the herd. The formation of injection-site lesions (ISLs) is a risk when using injectable pro... Read More about Injection-site lesion prevalence and potential risk factors in UK beef cattle.

STAT2 is a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways (2016)
Journal Article

STAT2 is the quintessential transcription factor for type 1 interferons (IFNs), where it functions as a heterodimer with STAT1. However, the human and murine STAT2-deficient phenotypes suggest important additional and currently unidentified type 1 IF... Read More about STAT2 is a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways.

PIMMS (Pragmatic Insertional Mutation Mapping System) laboratory methodology a readily accessible tool for identification of essential genes in Streptococcus (2016)
Journal Article

The Pragmatic Insertional Mutation Mapping (PIMMS) laboratory protocol was developed alongside various bioinformatics packages (Blanchard et al., 2015) to enable detection of essential and conditionally essential genes in Streptococcus and related ba... Read More about PIMMS (Pragmatic Insertional Mutation Mapping System) laboratory methodology a readily accessible tool for identification of essential genes in Streptococcus.

A method for extracting electronic patient record data from practice management software systems used in veterinary practice (2016)
Journal Article

Background Data extracted from electronic patient records (EPRs) within practice management software systems are increasingly used in veterinary research. The use of real patient data gives the potential to generate research that can readily be appl... Read More about A method for extracting electronic patient record data from practice management software systems used in veterinary practice.

Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection (2016)
Journal Article

Tuberculosis (TB) causes significant morbidity and mortality on a global scale. The African region has 24% of the world's TB cases. TB overlaps with other infectious diseases such as malaria and HIV, which are also highly prevalent in the African reg... Read More about Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection.

Global population divergence and admixture of the brown rat (Rattus norvegicus) (2016)
Journal Article

Native to China and Mongolia, the brown rat (Rattus norvegicus) now enjoys a worldwide distribution. While black rats and the house mouse tracked the regional development of human agricultural settlements, brown rats did not appear in Europe until th... Read More about Global population divergence and admixture of the brown rat (Rattus norvegicus).

A sensitive 301V BSE serial PMCA assay (2016)
Journal Article

The prion strain 301V, is a mouse passaged form of bovine spongiform encephalopathy (BSE). It has been used as a model of BSE for more than 20 years, in particular in the investigation of tissue distribution of infectivity, the molecular phenotype an... Read More about A sensitive 301V BSE serial PMCA assay.

The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport (2016)
Journal Article

Fetal exposure to a maternal low protein diet during rat pregnancy is associated with hypertension, renal dysfunction and metabolic disturbance in adult life. These effects are present when dietary manipulations target only the first half of pregnanc... Read More about The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport.

Exploring attitudes and beliefs towards implementing cattle disease prevention and control measures: a qualitative study with dairy farmers in Great Britain (2016)
Journal Article

Disease prevention and control practices are frequently highlighted as important to ensure the health and welfare of farmed animals, although little is known as to why not many practices are carried out. The aim of this study was to identify the moti... Read More about Exploring attitudes and beliefs towards implementing cattle disease prevention and control measures: a qualitative study with dairy farmers in Great Britain.

Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration (2016)
Journal Article

Carbonic anhydrase inhibitors are used to treat glaucoma and cancers. Carbonic anhydrases perform a crucial role in the conversion of carbon dioxide and water into bicarbonate and protons. However, there is little information about carbonic anhydrase... Read More about Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration.

Malignant inflammation in cutaneous T-cell lymphoma: a hostile takeover (2016)
Journal Article

Cutaneous T-cell lymphomas (CTCL) are characterized by the presence of chronically inflamed skin lesions containing malignant T cells. Early disease presents as limited skin patches or plaques and exhibits an indolent behavior. For many patients, the... Read More about Malignant inflammation in cutaneous T-cell lymphoma: a hostile takeover.

Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies (2016)
Journal Article

Despite reports of the successful isolation of primary equine hepatocytes, thereare no published data regarding the successful cryopreservation of these isolatedcells. In this study, a detailed description of the procedures for isolation, cryop-reser... Read More about Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies.

A systematic review of the literature relating to captive great ape morbidity and mortality (2016)
Journal Article

Wild bonobos (Pan paniscus), chimpanzees (Pan troglodytes), Western gorillas (Gorilla gorilla), and orangutans (Pongo pygmaeus, Pongo abelii) are threatened with extinction. In order to help maintain a self-sustaining zoo population, clinicians requi... Read More about A systematic review of the literature relating to captive great ape morbidity and mortality.