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Molecular epidemiology of Streptococcus uberis clinical mastitis in dairy herds: strain heterogeneity and transmission (2015)
Journal Article
Davies, P., Archer, S. C., Emes, R. D., Bradley, A. J., Leigh, J., & Green, M. J. (2016). Molecular epidemiology of Streptococcus uberis clinical mastitis in dairy herds: strain heterogeneity and transmission. Journal of Clinical Microbiology, 54(1), https://doi.org/10.1128/JCM.01583-15

Multi Locus Sequence Typing was successfully completed on 494 isolates of S. uberis from clinical mastitis cases in a study of 52 commercial dairy herds over a 12 month period. In total, 195 sequence types (STs) were identified. S. uberis mastitis ca... Read More about Molecular epidemiology of Streptococcus uberis clinical mastitis in dairy herds: strain heterogeneity and transmission.

Benazepril in dogs with asymptomatic mitral valve disease (2015)
Journal Article
Brennan, M. L., & Stavisky, J. (2015). Benazepril in dogs with asymptomatic mitral valve disease. Veterinary Record, 177(15), https://doi.org/10.1136/vr.h4110

BestBETs for Vets are generated by the Centre for Evidence-based Veterinary Medicine at the University of Nottingham to help answer specific questions and assist in clinical decision making. Although evidence is often limited, they aim to find, prese... Read More about Benazepril in dogs with asymptomatic mitral valve disease.

Prospective study of the primary evaluation of 1016 horses with clinical signs of abdominal pain by veterinary practitioners, and the differentiation of critical and non?critical cases (2015)
Journal Article
Curtis, L., Burford, J., Thomas, J. S. M., Curran, M. L., Bayes, T. C., England, G. C., & Freeman, S. (in press). Prospective study of the primary evaluation of 1016 horses with clinical signs of abdominal pain by veterinary practitioners, and the differentiation of critical and non?critical cases. Acta Veterinaria Scandinavica, 57(69), https://doi.org/10.1186/s13028-015-0160-9

Background: The majority of research on the evaluation of horses with colic is focused on referral hospital populations. Early identification of critical cases is important to optimise outcome and welfare. The aim of this prospective study was to sur... Read More about Prospective study of the primary evaluation of 1016 horses with clinical signs of abdominal pain by veterinary practitioners, and the differentiation of critical and non?critical cases.

MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators (2015)
Journal Article
Nilsson, E. M., Laursen, K. B., Whitchurch, J., McWilliam, A., Ødum, N., Persson, J. L., …Mongan, N. P. (2015). MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators. Oncotarget, 6(34), 35710-35725. https://doi.org/10.18632/oncotarget.5958

Androgens and the androgen receptor (AR) play crucial roles in male development and the pathogenesis and progression of prostate cancer (PCa). The AR functions as a ligand dependent transcription factor which recruits multiple enzymatically distinct... Read More about MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators.

Development of a framework for genotyping bovine-derived Cryptosporidium parvum, using a multilocus fragment typing tool (2015)
Journal Article
Hotchkiss, E. J., Gilray, J. A., Brennan, M. L., Christley, R. M., Morrison, L. J., Jonsson, N. N., …Katzer, F. (2015). Development of a framework for genotyping bovine-derived Cryptosporidium parvum, using a multilocus fragment typing tool. Parasites and Vectors, 8(1), Article 500. https://doi.org/10.1186/s13071-015-1107-8

Background: There is a need for an integrated genotyping approach for C. parvum; no sufficiently discriminatory scheme to date has been fully validated or widely adopted by veterinary or public health researchers. Multilocus fragment typing (MLFT) ca... Read More about Development of a framework for genotyping bovine-derived Cryptosporidium parvum, using a multilocus fragment typing tool.

Veterinary practitioners’ selection of diagnostic tests for the primary evaluation of colic in the horse (2015)
Journal Article
England, G. C. W., Curtis, L., Trewin, I., England, G. C., Burford, J. H., & Freeman, S. L. (2015). Veterinary practitioners’ selection of diagnostic tests for the primary evaluation of colic in the horse. Veterinary Record Open, 2(2), Article e000145. https://doi.org/10.1136/vetreco-2015-000145

The aim of this study was to survey veterinary practitioners’ selection of diagnostic tests for horses with clinical signs of abdominal pain. A questionnaire was distributed to veterinary surgeons involved in the primary evaluation of horses with abd... Read More about Veterinary practitioners’ selection of diagnostic tests for the primary evaluation of colic in the horse.

Reduction in daily milk yield associated with sub-clinical bovine herpes virus 1 infection (2015)
Journal Article
Statham, J. M., Randall, L. V., & Archer, S. C. (2015). Reduction in daily milk yield associated with sub-clinical bovine herpes virus 1 infection. Veterinary Record, 177(13), Article 339. https://doi.org/10.1136/vr.103105

The aim of this observational cohort study was to investigate the potential economic effect of sub-clinical Bovine Herpes Virus 1 (BoHV-1) infection in a commercial UK dairy herd in terms of milk yield depression. Infection status of cows (infected... Read More about Reduction in daily milk yield associated with sub-clinical bovine herpes virus 1 infection.

Campylobacter jejuni PflB is required for motility and colonisation of the chicken gastrointestinal tract (2015)
Journal Article
Kanji, A., Jones, M., Maskell, D. J., & Grant, A. J. (2015). Campylobacter jejuni PflB is required for motility and colonisation of the chicken gastrointestinal tract. Microbial Pathogenesis, 89, https://doi.org/10.1016/j.micpath.2015.09.010

Campylobacter jejuni is the leading cause of foodborne bacterial gastroenteritis worldwide. Although the mechanisms by which C. jejuni causes disease are not completely understood, the presence of functional flagella appears to be required for coloni... Read More about Campylobacter jejuni PflB is required for motility and colonisation of the chicken gastrointestinal tract.

Changes in prevalence of, and risk factors for, lameness in random samples of English sheep flocks: 2004–2013 (2015)
Journal Article
Winter, J. R., Kaler, J., Ferguson, E., KilBride, A. L., & Green, L. E. (2015). Changes in prevalence of, and risk factors for, lameness in random samples of English sheep flocks: 2004–2013. Preventive Veterinary Medicine, 122(1-2), 121-128. https://doi.org/10.1016/j.prevetmed.2015.09.014

The aims of this study were to update the prevalence of lameness in sheep in England and identify novel risk factors. A total of 1260 sheep farmers responded to a postal survey. The survey captured detailed information on the period prevalence of lam... Read More about Changes in prevalence of, and risk factors for, lameness in random samples of English sheep flocks: 2004–2013.

Diversity of group A rotavirus on a UK pig farm (2015)
Journal Article
Chandler-Bostock, R., Hancox, L., Payne, H., Iturriza-Gomara, M., Daly, J. M., & Mellits, K. (2015). Diversity of group A rotavirus on a UK pig farm. Veterinary Microbiology, 180(3-4), 205-211. https://doi.org/10.1016/j.vetmic.2015.09.009

Group A rotaviruses (GARV) are a significant cause of enteritis in young pigs. The aim of this study was to extend our understanding of the molecular epidemiology of porcine GARV in the UK by investigating the genetic diversity of GARV on a conventio... Read More about Diversity of group A rotavirus on a UK pig farm.

Detection of viable Mycobacterium avium subspecies paratuberculosis in powdered infant formula by phage-PCR and confirmed by culture (2015)
Journal Article
Rees, C., Botsaris, G., Swift, B. M., Slana, I., Liapi, M., Christodoulou, M., …Christodoulou, V. (2016). Detection of viable Mycobacterium avium subspecies paratuberculosis in powdered infant formula by phage-PCR and confirmed by culture. International Journal of Food Microbiology, 216, 91-94. https://doi.org/10.1016/j.ijfoodmicro.2015.09.011

VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria (2015)
Journal Article
Canavese, M., Dottorini, T., & Crisanti, A. (2015). VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria. Pathogens and Global Health, 109(6), doi:10.1179/2047773215Y.0000000018

Malaria infection induces, alongside endothelial damage and obstruction hypoxia, a potent inflammatory response similar to that observed in other systemic diseases caused by bacteria and viruses. Accordingly, it is increasingly recognised that cerebr... Read More about VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria.

Extended 2D myotube culture recapitulates postnatal fibre type plasticity (2015)
Journal Article
Sebastian, S., Goulding, L., Kuchipudi, S. V., & Chang, K. (in press). Extended 2D myotube culture recapitulates postnatal fibre type plasticity. BMC Cell Biology, 16(1), https://doi.org/10.1186/s12860-015-0069-1

Background: The traditional problems of performing skeletal muscle cell cultures derived from mammalian or avian species are limited myotube differentiation, and transient myotube persistence which greatly restricts the ability of myotubes to undergo... Read More about Extended 2D myotube culture recapitulates postnatal fibre type plasticity.

Objects in contact with classical scrapie sheep act as a reservoir for scrapie transmission (2015)
Journal Article
Konold, T., Hawkins, S. A., Thurston, L. C., Maddison, B. C., Gough, K. C., Duarte, A., & Simmons, H. A. (2015). Objects in contact with classical scrapie sheep act as a reservoir for scrapie transmission. Frontiers in Veterinary Science, 2, Article 32. https://doi.org/10.3389/fvets.2015.00032

Classical scrapie is an environmentally transmissible prion disease of sheep and goats. Prions can persist and remain potentially infectious in the environment for many years and thus pose a risk of infecting animals after re-stocking. In vitro studi... Read More about Objects in contact with classical scrapie sheep act as a reservoir for scrapie transmission.

Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer (2015)
Journal Article
Kitchen, M. O., Bryan, R. T., Haworth, K. E., Emes, R. D., Luscombe, C., Gommersall, L., …Farrell, W. E. (2015). Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer. PLoS ONE, 10(9), e0137003. https://doi.org/10.1371/journal.pone.0137003

Introduction Inappropriate DNA methylation is frequently associated with human tumour development, and in specific cases, is associated with clinical outcomes. Previous reports of DNA methylation in low/intermediate grade non-muscle invasive bladd... Read More about Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer.

PA-X is a virulence factor in avian H9N2 influenza virus (2015)
Journal Article
Gao, H., Liu, J., Kong, W., Sun, H., Pu, J., Chang, K., …Wang, J. (2015). PA-X is a virulence factor in avian H9N2 influenza virus. Journal of General Virology, 96(9), https://doi.org/10.1099/jgv.0.000232

H9N2 influenza viruses have been circulating worldwide in multiple avian species, and regularly infect pigs and humans. Recently, a novel protein, PA-X, produced from the PA gene by ribosomal frameshifting, was demonstrated to be an antivirulence fac... Read More about PA-X is a virulence factor in avian H9N2 influenza virus.

Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni) (2015)
Journal Article
de Brot, S., Sydler, T., Nufer, L., & Ruetten, M. (2015). Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni). Journal of Zoo and Wildlife Medicine, 46(3), https://doi.org/10.1638/2013-0113.1

A dwarf bearded dragon (Pogona henrylawsoni) was presented with a whitish subcutaneous mandibular mass and multiple nodules in the oral mucosa, heart, liver, kidney, intestine and visceral fat. Histologically, the tumor consisted of densely packed sp... Read More about Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni).

Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma (2015)
Journal Article
Sibbesen, N. A., Kopp, K. L., Litvinov, I. V., Jønson, L., Willerslev-Olsen, A., Fredholm, S., …Odum, N. (2015). Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma. Oncotarget, 6(24),

Aberrant activation of Janus kinase-3 (Jak3) and its key down-stream effectors, Signal Transducer and Activator of Transcription-3 (STAT3) and STAT5, is a key feature of malignant transformation in cutaneous T-cell lymphoma (CTCL). However, it remain... Read More about Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma.

Recycling manure as cow bedding: potential benefits and risks for UK dairy farms (2015)
Journal Article
Lech, K. A., Archer, S. C., Breen, J. E., Green, M. J., Ohnstad, I. C., Tuer, S., & Bradley, A. J. (in press). Recycling manure as cow bedding: potential benefits and risks for UK dairy farms. Veterinary Journal, 206(2), https://doi.org/10.1016/j.tvjl.2015.08.013

Material obtained from physical separation of slurry (recycled manure solids; RMS) has been used as bedding for dairy cows in dry climates in the US since the 1970s. Relatively recently, the technical ability to produce drier material has led to adop... Read More about Recycling manure as cow bedding: potential benefits and risks for UK dairy farms.