All Outputs (213)

Whole-genome sequence data uncover widespread heterothallism in the largest group of lichen-forming fungi (2019)
Journal Article
Pizarro, D., Dal Grande, F., Don Leavitt, S., Stanley Dyer, P., Schmitt, I., Crespo, A., …Kumar Divakar, P. (2019). Whole-genome sequence data uncover widespread heterothallism in the largest group of lichen-forming fungi. Genome Biology and Evolution, 11(3), 721-730. https://doi.org/10.1093/gbe/evz027

Fungal reproduction is regulated by the mating-type (MAT1) locus, which typically comprises two idiomorphic genes. The presence of one or both allelic variants at the locus determines the reproductive strategy in Fungi – homothallism vs. heterothalli... Read More about Whole-genome sequence data uncover widespread heterothallism in the largest group of lichen-forming fungi.

Investigating the intracellular effects of hyperbranched polycation-DNA complexes on lung cancer cells using LC-MS-based metabolite profiling (2019)
Journal Article
Alazzo, A., Al-Natour, M., Spriggs, K., Stolnik, S., Ghaemmaghami, A., Kim, D.-H., & Alexander, C. (2019). Investigating the intracellular effects of hyperbranched polycation-DNA complexes on lung cancer cells using LC-MS-based metabolite profiling. Molecular Omics, 15(1), 77-87. https://doi.org/10.1039/C8MO00139A

Cationic polymers have emerged as a promising alternative to viral vectors in gene therapy. They are cheap to scale up, easy to functionalise and also presume to be safer than the viral vectors, however many of them are cytotoxic. The large number of... Read More about Investigating the intracellular effects of hyperbranched polycation-DNA complexes on lung cancer cells using LC-MS-based metabolite profiling.

Testing for hepatitis C virus infection in UK prisons: what actually happens? (2019)
Journal Article
Jack, K., Thomson, B. J., & Irving, W. L. (2019). Testing for hepatitis C virus infection in UK prisons: what actually happens?. Journal of Viral Hepatitis, 26(6), 644-654. https://doi.org/10.1111/jvh.13071

Prisons are a key demographic in the drive to eradicate hepatitis C virus (HCV) as a major public health threat. We have assessed the impact of the recently introduced national opt-out policy on the current status of HCV testing in 14 prisons in the... Read More about Testing for hepatitis C virus infection in UK prisons: what actually happens?.

Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis (2019)
Journal Article
Ramos-Ibeas, P., Sang, F., Zhu, Q., Wang, W. W., Withey, S., Klisch, D., …Alberio, R. (2019). Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis. Nature Communications, 10, Article 500. https://doi.org/10.1038/s41467-019-08387-8

High-resolution molecular programmes delineating the cellular foundations of mammalian embryogenesis have emerged recently. Similar analysis of human embryos is limited to pre-implantation stages, since early post-implantation embryos are largely ina... Read More about Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis.

A foreign body response-on-a-chip platform (2019)
Journal Article
Sharifi, F., Htwe, S. S., Righi, M., Liu, H., Peietralunga, A., Yesil-Celiktas, O., …Zhang, Y. S. (2019). A foreign body response-on-a-chip platform. Advanced Healthcare Materials, 8(4), 1-10. https://doi.org/10.1002/adhm.201801425

Understanding the foreign body response (FBR) and desiging strategies to modulate such a response represent a grand challenge for implant devices and biomaterials. Here, the development of a microfluidic platform is reported, i.e., the FBR‐on‐a‐chip... Read More about A foreign body response-on-a-chip platform.

The Hepatitis C Awareness Through to Treatment (HepCATT) study: improving the cascade of care for hepatitis C virus-infected people who inject drugs in England (2019)
Journal Article
Harrison, G. I., Murray, K., Gore, R., Lee, P., Sreedharan, A., Richardson, P., …Irving, W. L. (2019). The Hepatitis C Awareness Through to Treatment (HepCATT) study: improving the cascade of care for hepatitis C virus-infected people who inject drugs in England. Addiction, 114(6), 1113-1122. https://doi.org/10.1111/add.14569

Background and Aims: Previous studies have shown low rates of diagnosis and treatment of hepatitis C virus (HCV) infection in people who inject drugs (PWID). Our aims were to test the effect of a complex intervention (“HepCATT”) in drug and alcohol c... Read More about The Hepatitis C Awareness Through to Treatment (HepCATT) study: improving the cascade of care for hepatitis C virus-infected people who inject drugs in England.

Venous identity requires BMP signalling through ALK3 (2019)
Journal Article
Neal, A., Nornes, S., Payne, S., Wallace, M. D., Fritzsche, M., Louphrasitthiphol, P., …De Val, S. (2019). Venous identity requires BMP signalling through ALK3. Nature Communications, 10(1), 1-18. https://doi.org/10.1038/s41467-019-08315-w

Venous endothelial cells are molecularly and functionally distinct from their arterial counterparts. Although veins are often considered the default endothelial state, genetic manipulations can modulate both acquisition and loss of venous fate, sugge... Read More about Venous identity requires BMP signalling through ALK3.

Predictable genome-wide sorting of standing genetic variation during parallel adaptation to basic versus acidic environments in stickleback fish (2019)
Journal Article
Haenel, Q., Roesti, M., Moser, D., MacColl, A. D., & Berner, D. (2019). Predictable genome-wide sorting of standing genetic variation during parallel adaptation to basic versus acidic environments in stickleback fish. Evolution Letters, 3(1), 28-42. https://doi.org/10.1002/evl3.99

Genomic studies of parallel (or convergent) evolution often compare multiple populations diverged into two ecologically different habitats to search for loci repeatedly involved in adaptation. Because the shared ancestor of these populations is gener... Read More about Predictable genome-wide sorting of standing genetic variation during parallel adaptation to basic versus acidic environments in stickleback fish.

Do Antiretroviral Drugs Protect From Multiple Sclerosis By Inhibiting Expression Of MS-Associated Retrovirus? (2019)
Journal Article
Morandi, E., Tanasescu, R., Tarlington, R., Constantin-Teodosiu, D., & Gran, B. (2019). Do Antiretroviral Drugs Protect From Multiple Sclerosis By Inhibiting Expression Of MS-Associated Retrovirus?. Frontiers in Immunology, 9, Article 3092. https://doi.org/10.3389/fimmu.2018.03092

The expression of human endogenous retroviruses (HERVs) has been associated with Multiple Sclerosis (MS). The MS-related retrovirus (MSRV/HERV-W) has the potential to activate inflammatory immunity, which could promote both susceptibility and progres... Read More about Do Antiretroviral Drugs Protect From Multiple Sclerosis By Inhibiting Expression Of MS-Associated Retrovirus?.

Examining diabetic heel ulcers through an ecological lens: microbial community dynamics associated with healing and infection (2019)
Journal Article
Sloan, T. J., Turton, J. C., Tyson, J., Musgrove, A., Fleming, V. M., Lister, M. M., …Jeffcoate, W. (2019). Examining diabetic heel ulcers through an ecological lens: microbial community dynamics associated with healing and infection. Journal of Medical Microbiology, 68(2), 230-240. https://doi.org/10.1099/jmm.0.000907

Purpose: While some micro-organisms, such as Staphylococcus aureus, are clearly implicated in causing tissue damage in diabetic foot ulcers (DFUs), our knowledge of the contribution of the entire microbiome to clinical outcomes is limited. We profile... Read More about Examining diabetic heel ulcers through an ecological lens: microbial community dynamics associated with healing and infection.

Genome-Wide Variation, Candidate Regions and Genes Associated With Fat Deposition and Tail Morphology in Ethiopian Indigenous Sheep (2019)
Journal Article
Ahbara, A., Bahbahani, H., Almathen, F., Al Abri, M., Agoub, M. O., Abeba, A., …Mwacharo, J. M. (2019). Genome-Wide Variation, Candidate Regions and Genes Associated With Fat Deposition and Tail Morphology in Ethiopian Indigenous Sheep. Frontiers in Genetics, 9, Article 699. https://doi.org/10.3389/fgene.2018.00699

Variations in body weight and in the distribution of body fat are associated with feed availability, thermoregulation, and energy reserve. Ethiopia is characterized by distinct agro-ecological and human ethnic farmer diversity of ancient origin, whic... Read More about Genome-Wide Variation, Candidate Regions and Genes Associated With Fat Deposition and Tail Morphology in Ethiopian Indigenous Sheep.

Haloferax volcanii for biotechnology applications: challenges, current state and perspectives (2019)
Journal Article
Haque, R. U., Paradisi, F., & Allers, T. (2019). Haloferax volcanii for biotechnology applications: challenges, current state and perspectives. Applied Microbiology and Biotechnology, 1-12. https://doi.org/10.1007/s00253-019-10314-2

© 2019, The Author(s). Haloferax volcanii is an obligate halophilic archaeon with its origin in the Dead Sea. Simple laboratory culture conditions and a wide range of genetic tools have made it a model organism for studying haloarchaeal cell biology.... Read More about Haloferax volcanii for biotechnology applications: challenges, current state and perspectives.

Genetic variability in response to amyloid beta deposition influences Alzheimer’s disease risk (2019)
Journal Article
Salih, D. A., Bayram, S., Guelfi, S., Reynolds, R. H., Shoai, M., Ryten, M., …Hardy, J. (2019). Genetic variability in response to amyloid beta deposition influences Alzheimer’s disease risk. Brain Communications, 1(1), Article fcz022. https://doi.org/10.1093/braincomms/fcz022

Genome-wide association studies of late-onset Alzheimer’s disease risk have previously identified genes primarily expressed in microglia that form a transcriptional network. Using transgenic mouse models of amyloid deposition, we previously showed th... Read More about Genetic variability in response to amyloid beta deposition influences Alzheimer’s disease risk.