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A foreign body response-on-a-chip platform

Sharifi, Fatemeh; Htwe, Su Su; Righi, Martina; Liu, Hua; Peietralunga, Anna; Yesil-Celiktas, Ozlem; Maharjan, Sushila; Cha, Byung-Hyun; Shin, Su-Ryon; Dokmeci, Mehmet Remzi; Vrana, Nihal Engin; Ghaemmaghammi, Amir M.; Khademhosseini, Ali; Zhang, Yu Shrike


Fatemeh Sharifi

Su Su Htwe

Martina Righi

Hua Liu

Anna Peietralunga

Ozlem Yesil-Celiktas

Sushila Maharjan

Byung-Hyun Cha

Su-Ryon Shin

Mehmet Remzi Dokmeci

Nihal Engin Vrana

Ali Khademhosseini

Yu Shrike Zhang


Understanding the foreign body response (FBR) and desiging strategies to modulate such a response represent a grand challenge for implant devices and biomaterials. Here, the development of a microfluidic platform is reported, i.e., the FBR‐on‐a‐chip (FBROC) for modeling the cascade of events during immune cell response to implants. The platform models the native implant microenvironment where the implants are interfaced directly with surrounding tissues, as well as vasculature with circulating immune cells. The study demonstrates that the release of cytokines such as monocyte chemoattractant protein 1 (MCP‐1) from the extracellular matrix (ECM)‐like hydrogels in the bottom tissue chamber induces trans‐endothelial migration of circulating monocytes in the vascular channel toward the hydrogels, thus mimicking implant‐induced inflammation. Data using patient‐derived peripheral blood mononuclear cells further reveal inter‐patient differences in FBR, highlighting the potential of this platform for monitoring FBR in a personalized manner. The prototype FBROC platform provides an enabling strategy to interrogate FBR on various implants, including biomaterials and engineered tissue constructs, in a physiologically relevant and individual‐specific manner.


Sharifi, F., Htwe, S. S., Righi, M., Liu, H., Peietralunga, A., Yesil-Celiktas, O., …Zhang, Y. S. (2019). A foreign body response-on-a-chip platform. Advanced Healthcare Materials, 8(4), 1-10.

Journal Article Type Article
Acceptance Date Jan 2, 2019
Online Publication Date Jan 29, 2019
Publication Date Feb 21, 2019
Deposit Date Jan 23, 2019
Publicly Available Date Jan 30, 2020
Journal Advanced Healthcare Materials
Print ISSN 2192-2640
Electronic ISSN 2192-2659
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 8
Issue 4
Article Number 1801425
Pages 1-10
Keywords foreign body response; immune response; implant, biomaterials; organ-on-a-chip
Public URL
Publisher URL
Additional Information This is the peer reviewed version of the following article: F. Sharifi, S. S. Htwe, M. Righi, H. Liu, A. Pietralunga, O. Yesil‐Celiktas, S. Maharjan, B.‐H. Cha, S. R. Shin, M. R. Dokmeci, N. E. Vrana, A. M. Ghaemmaghami, A. Khademhosseini, Y. S. Zhang, Advanced Healthcare Materials 2019, 1801425. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.