A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia
(2018)
Journal Article
Foxler, D. E., Bridge, K. S., Foster, J. G., Grevitt, P., Curry, S., Shah, K. M., …Sharp, T. V. (in press). A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. EMBO Molecular Medicine, Article e8304. https://doi.org/10.15252/emmm.201708304
The adaptive cellular response to low oxygen tensions is mediated by the hypoxia inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and β subunits. Prolonged HIF expression is a key contributor to cellular t... Read More about A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia.