All Outputs (212)

Recognition of membrane sterols by polyene antifungals amphotericin B and natamycin, a 13C MAS NMR Study (2016)
Journal Article
Ciesielski, F., Griffin, D. C., Loraine, J., Rittig, M., Delves-Broughton, J., & Bonev, B. B. (in press). Recognition of membrane sterols by polyene antifungals amphotericin B and natamycin, a 13C MAS NMR Study. Frontiers in Cell and Developmental Biology, 4, https://doi.org/10.3389/fcell.2016.00057

The molecular action of polyene macrolides with antifungal activity, amphotericin B and natamycin, involves recognition of sterols in membranes. Physicochemical and functional studies have contributed details to understanding the interactions between... Read More about Recognition of membrane sterols by polyene antifungals amphotericin B and natamycin, a 13C MAS NMR Study.

?2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer (2016)
Journal Article
Chang, A., Le, C. P., Walker, A. K., Creed, S. J., Pon, C. K., Albold, S., …Sloan, E. K. (2016). β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer. Brain, Behavior, and Immunity, 57, 106-115. https://doi.org/10.1016/j.bbi.2016.06.011

© 2016 The Authors Chronic stress accelerates metastasis – the main cause of death in cancer patients – through the activation of β-adrenoceptors (βARs). We have previously shown that β2AR signaling in MDA-MB-231HM breast cancer cells, facilitates in... Read More about ?2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer.

Irregular meal-pattern effects on energy expenditure, metabolism, and appetite regulation: a randomized controlled trial in healthy normal-weight women (2016)
Journal Article
Alhussain, M. H., Macdonald, I. A., & Taylor, M. A. (2016). Irregular meal-pattern effects on energy expenditure, metabolism, and appetite regulation: a randomized controlled trial in healthy normal-weight women. American Journal of Clinical Nutrition, 104(1), 21-32. https://doi.org/10.3945/ajcn.115.125401

Background: Obesity is increasing in parallel with greater all-day food availability. The latter may promote meal irregularity, dysregulation of the energy balance, and poor metabolic health. Objective: We investigated the effect of meal irregularit... Read More about Irregular meal-pattern effects on energy expenditure, metabolism, and appetite regulation: a randomized controlled trial in healthy normal-weight women.

Bright spots among the world's coral reefs (2016)
Journal Article
Cinner, J. E., Huchery, C., Macneill, M. A., Graham, N. A., McClanahan, T. R., Maina, J., …Mouillot, D. (2016). Bright spots among the world's coral reefs. Nature, 535(7612), 416-419. https://doi.org/10.1038/nature18607

© 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Ongoing declines in the structure and function of the world's coral reefs require novel approaches to sustain these ecosystems and the millions of people who depend on... Read More about Bright spots among the world's coral reefs.

Ancient and modern DNA reveal dynamics of domestication and cross-continental dispersal of the dromedary (2016)
Journal Article
Almathen, F., Charruau, P., Mohandesan, E., Mwacharo, J. M., Orozco-terWengel, P., Pitt, D., …Burger, P. A. (2016). Ancient and modern DNA reveal dynamics of domestication and cross-continental dispersal of the dromedary. Proceedings of the National Academy of Sciences, 113(24), https://doi.org/10.1073/pnas.1519508113

Dromedaries have been fundamental to the development of human societies in arid landscapes and for long-distance trade across hostile hot terrains for 3,000 y. Today they continue to be an important livestock resource in marginal agro-ecological zone... Read More about Ancient and modern DNA reveal dynamics of domestication and cross-continental dispersal of the dromedary.

The impact of surface chemistry modification on macrophage polarisation (2016)
Journal Article
Rostam, H., Singh, S., Salazar, F., Magennis, P., Hook, A. L., Singh, T., …Ghaemmaghami, A. M. (2016). The impact of surface chemistry modification on macrophage polarisation. Immunobiology, 221(11), 1237-1246. https://doi.org/10.1016/j.imbio.2016.06.010

Macrophages are innate immune cells that have a central role in combating infection and maintaining tissue homeostasis. They exhibit remarkable plasticity in response to environmental cues. At either end of a broad activation spectrum are pro-inflamm... Read More about The impact of surface chemistry modification on macrophage polarisation.

A low-cost paper-based model for on-chip human respiratory system studies (2016)
Conference Proceeding
Rahimi, R., Ochoa, M., Htwe, S. S., Donaldson, A., Zieger, M., Dokmeci, M. R., …Ziaie, B. (2016). A low-cost paper-based model for on-chip human respiratory system studies. In Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016 (206-209). https://doi.org/10.31438/trf.hh2016.56

© 2016 TRF We present the use of hydrophobic paper as an effective semipermeable membrane, ideal for air-liquid interface cell culture applications. The surface properties of the paper is modified through selective CO2 laser-assisted scrubbing to cre... Read More about A low-cost paper-based model for on-chip human respiratory system studies.

The multidrug transporter ABCG2: still more questions than answers (2016)
Journal Article
Horsey, A. J., Cox, M. H., Sarwat, S., & Kerr, I. D. (2016). The multidrug transporter ABCG2: still more questions than answers. Biochemical Society Transactions, 44(3), 824-830. https://doi.org/10.1042/BST20160014

ABCG2 is one of at least three human ATP binding cassette (ABC) transporters which can facilitate the export from cells of a wide range of chemically unrelated drug molecules. This capacity for multidrug transport is not only a confounding factor in... Read More about The multidrug transporter ABCG2: still more questions than answers.

Mitochondrial function and dynamics imaged in vivo (2016)
Book Chapter
Chisholm, K., Peters, F., Schiza, D. G., Sadeghian, M., & Smith, K. (2016). Mitochondrial function and dynamics imaged in vivo. In A. K. Reeve, E. M. Simcox, M. R. Duchen, & D. M. Turnbull (Eds.), Mitochondrial Dysfunction in Neurodegenerative Disorders (329-345). Cham: Springer. https://doi.org/10.1007/978-3-319-28637-2_14

The previous chapters have described the extraordinary depth of knowledge of mitochondrial biology revealed by in vitro observations where the environment can be closely controlled. However, in recent years there has been increased interest in the st... Read More about Mitochondrial function and dynamics imaged in vivo.

Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor (2016)
Journal Article
Thompson, G., Lane, J., Coudrat, T., Sexton, P., Christopoulos, A., & Canals, M. (2016). Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor. Biochemical Pharmacology, 113, 70-87. https://doi.org/10.1016/j.bcp.2016.05.014

Biased agonism describes the ability of distinct G protein-coupled receptor (GPCR) ligands to stabilise distinct receptor conformations leading to the activation of different cell signalling pathways that can deliver different physiologic outcomes. T... Read More about Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor.

The Effect of Normobaric Hypoxic Confinement on Metabolism, Gut Hormones, and Body Composition (2016)
Journal Article
Mekjavic, I. B., Amon, M., Kölegård, R., Kounalakis, S. N., Simpson, L., Eiken, O., …Macdonald, I. A. (2016). The Effect of Normobaric Hypoxic Confinement on Metabolism, Gut Hormones, and Body Composition. Frontiers in Physiology, 7, Article 202. https://doi.org/10.3389/fphys.2016.00202

To assess the effect of normobaric hypoxia on metabolism, gut hormones, and body composition, 11 normal weight, aerobically trained (O2peak: 60.6 ± 9.5 ml·kg-1·min-1) men (73.0 ± 7.7 kg; 23.7 ± 4.0 years, BMI 22.2 ± 2.4 kg·m-2) were confined to a nor... Read More about The Effect of Normobaric Hypoxic Confinement on Metabolism, Gut Hormones, and Body Composition.

The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator (2016)
Journal Article
Dunajova, L., Cash, E., Markus, R., Rochette, S., Townley, A. R., & Wheatley, S. P. (in press). The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator. Journal of Cell Science, 129, https://doi.org/10.1242/jcs.183277

Survivin is a cancer-associated protein that exists in several locations in the cell. Its cytoplasmic residence in interphase cells is governed by CRM1-mediated nuclear exportation, and its localisation during mitosis to the centromeres and midzone m... Read More about The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator.

On the boundary layer structure near a highly permeable porous interface (2016)
Journal Article
Dalwadi, M. P., Chapman, S. J., Waters, S. L., & Oliver, J. M. (2016). On the boundary layer structure near a highly permeable porous interface. Journal of Fluid Mechanics, 798, 88-139. https://doi.org/10.1017/jfm.2016.308

The method of matched asymptotic expansions is used to study the canonical problem of steady laminar flow through a narrow two-dimensional channel blocked by a tight-fitting finite-length highly permeable porous obstacle. We investigate the behaviour... Read More about On the boundary layer structure near a highly permeable porous interface.

When genome-based approach meets the “Old but Good”: revealing genes involved in the antibacterial activity of Pseudomonas sp. P482 against soft rot pathogens (2016)
Journal Article
Krzyżanowska, D. M., Ossowicki, A., Rajewska, M., Maciąg, T., Jabłońska, M., Obuchowski, M., …Jafra, S. (2016). When genome-based approach meets the “Old but Good”: revealing genes involved in the antibacterial activity of Pseudomonas sp. P482 against soft rot pathogens. Frontiers in Microbiology, 7, Article 782. https://doi.org/10.3389/fmicb.2016.00782

Dickeya solani and Pectobacterium carotovorum subsp. brasiliense are recently established species of bacterial plant pathogens causing black leg and soft rot of many vegetables and ornamental plants. Pseudomonas sp. strain P482 inhibits the growth of... Read More about When genome-based approach meets the “Old but Good”: revealing genes involved in the antibacterial activity of Pseudomonas sp. P482 against soft rot pathogens.

Insights into CO2 fixation pathway of Clostridium autoethanogenumby targeted mutagenesis (2016)
Journal Article
Liew, F., Henstra, A. M., Winzer, K., Kopke, M., Simpson, S. D., & Minton, N. P. (in press). Insights into CO2 fixation pathway of Clostridium autoethanogenumby targeted mutagenesis. mBio, 7(3), Article e00427-16. https://doi.org/10.1128/mBio.00427-16

The future sustainable production of chemicals and fuels from nonpetrochemical resources and reduction of greenhouse gas emissions are two of the greatest societal challenges. Gas fermentation, which utilizes the ability of acetogenic bacteria such a... Read More about Insights into CO2 fixation pathway of Clostridium autoethanogenumby targeted mutagenesis.

A roadmap for gene system development in Clostridium (2016)
Journal Article
Minton, N. P., Ehsaan, M., Humphreys, C. M., Little, G. T., Baker, J., Henstra, A. M., …Zhang, Y. (2016). A roadmap for gene system development in Clostridium. Anaerobe, 41, 104-112. https://doi.org/10.1016/j.anaerobe.2016.05.011

Clostridium species are both heroes and villains. Some cause serious human and animal diseases, those present in the microbiota contribute to health and wellbeing, while others represent useful industrial chassis for the production of chemicals and f... Read More about A roadmap for gene system development in Clostridium.

Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice (2016)
Journal Article
Ebada, M. E. E., Kendall, D. A., & Pardon, M. (2016). Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice. Behavioural Brain Research, 311, https://doi.org/10.1016/j.bbr.2016.05.051

Physical exercise can improve cognition but whether this is related to motivation levels is unknown. Voluntary wheel running is a rewarding activity proposed as a model of motivation to exercise. To question the potential effects of exercise motivati... Read More about Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice.

CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii (2016)
Journal Article
Li, Q., Cheng, J., Minton, N. P., Zhang, Y., Wen, Z., Liu, J., …Yang, S. (2016). CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii. Biotechnology Journal, 11(7), 961-972. https://doi.org/10.1002/biot.201600053

Solventogenic clostridia are important industrial microorganisms that produce various chemicals and fuels. Effective genetic tools would facilitate physiological studies aimed both at improving our understanding of metabolism and optimizing solvent p... Read More about CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii.

Damage limitation (2016)
Journal Article
Amelio, I., & Melino, G. (2016). Damage limitation. eLife, 5, https://doi.org/10.7554/elife.17394

A spring-loaded mechanism can explain the activation process for a protein that has a crucial role in maintaining the genomic integrity of immature eggs cells.

Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts (2016)
Journal Article
Lambert, C., Lerner, T. R., Bui, N. K., Somers, H., Aizawa, S., Liddell, S., …Sockett, R. E. (2016). Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts. Scientific Reports, 6:26010(1), https://doi.org/10.1038/srep26010

The peptidoglycan wall, located in the periplasm between the inner and outer membranes of the cell envelope in Gram-negative bacteria, maintains cell shape and endows osmotic robustness. Predatory Bdellovibrio bacteria invade the periplasm of other b... Read More about Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts.