All Outputs (2)

A systems biology viewpoint on autophagy in health and disease (2010)
Journal Article
Huett, A., Goel, G., & Xavier, R. J. (2010). A systems biology viewpoint on autophagy in health and disease. Current Opinion in Gastroenterology, 26(4), 302-309. https://doi.org/10.1097/MOG.0b013e32833ae2ed

Purpose of review: The field of autophagy is rapidly expanding to encompass many important areas of cell biology, physiology and disease. Recent discoveries and tools allow the connection of the autophagy pathway to other cellular signals and process... Read More about A systems biology viewpoint on autophagy in health and disease.

Human leucine-rich repeat proteins: A genome-wide bioinformatic categorization and functional analysis in innate immunity (2010)
Journal Article
Ng, A. C., Eisenberg, J. M., Heath, R. J., Huett, A., Robinson, C. M., Nau, G. J., & Xavier, R. J. (2011). Human leucine-rich repeat proteins: A genome-wide bioinformatic categorization and functional analysis in innate immunity. Proceedings of the National Academy of Sciences, 108(SUPPL. 1), 4631-4638. https://doi.org/10.1073/pnas.1000093107

In innate immune sensing, the detection of pathogen-associated molecular patterns by recognition receptors typically involve leucine-rich repeats (LRRs). We provide a categorization of 375 human LRR-containing proteins, almost half of which lack othe... Read More about Human leucine-rich repeat proteins: A genome-wide bioinformatic categorization and functional analysis in innate immunity.