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Female-limited colour polymorphism in the crab spider Synema globosum (Araneae: Thomisidae) (2014)
Journal Article
Ajuria Ibarra, H., & Reader, T. (2014). Female-limited colour polymorphism in the crab spider Synema globosum (Araneae: Thomisidae). Biological Journal of the Linnean Society, 113(2), https://doi.org/10.1111/bij.12338

Conspicuous colour variation, caused by the influence of the environment on phenotype, or by genetic differences among individuals, is frequently observed in nature. If genetic in origin, colour variation can facilitate the study of the mechanisms th... Read More about Female-limited colour polymorphism in the crab spider Synema globosum (Araneae: Thomisidae).

Multidomain Hybrid Hydrogels: Spatially Resolved Photopatterned Synthetic Nanomaterials Combining Polymer and Low‐Molecular‐Weight Gelators (2014)
Journal Article
Cornwell, D. J., Okesola, B. O., & Smith, D. K. (2014). Multidomain Hybrid Hydrogels: Spatially Resolved Photopatterned Synthetic Nanomaterials Combining Polymer and Low‐Molecular‐Weight Gelators. Angewandte Chemie, 126(46), 12669-12673. https://doi.org/10.1002/ange.201405098

A simple approach to a patterned multidomain gel is reported, combining a pH-responsive low-molecular-weight gelator (LMWG) and a photoinducible polymer gelator (PG). Using SEM (scanning electron microscopy), NMR spectroscopy, and CD, we demonstrate... Read More about Multidomain Hybrid Hydrogels: Spatially Resolved Photopatterned Synthetic Nanomaterials Combining Polymer and Low‐Molecular‐Weight Gelators.

Culturally valuable minority crops provide a succession of floral resources for flower visitors in traditional orchard gardens (2014)
Journal Article
Norfolk, O., Eichhorn, M. P., & Gilbert, F. (2014). Culturally valuable minority crops provide a succession of floral resources for flower visitors in traditional orchard gardens. Biodiversity and Conservation, 23(13), 3199-3217. https://doi.org/10.1007/s10531-014-0775-6

Agricultural intensification typically has detrimental effects on pollinator communities, but diverse cropping systems that contain sequentially-flowering crops have the potential to benefit pollinators through the provision of additional floral reso... Read More about Culturally valuable minority crops provide a succession of floral resources for flower visitors in traditional orchard gardens.

Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier (2014)
Journal Article
Elmorsy, E., Elzalabany, L. M., Elsheikha, H. M., & Smith, P. A. (2014). Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier. Brain Research, 1583(1), 255-268. https://doi.org/10.1016/j.brainres.2014.08.011

© 2014 Elsevier B.V. All rights reserved. Although the mechanisms of action of antipsychotics (APs) on neuronal function are well understood, very little is known about their effects on cells of the blood-brain barrier (BBB); one function of which is... Read More about Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier.

CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity (2014)
Journal Article
Sheridan, G. K., Wdowicz, A., Pickering, M., Watters, O., Halley, P., O'Sullivan, N. C., …Murphy, K. J. (2014). CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity. Frontiers in Cellular Neuroscience, 8, Article 233. https://doi.org/10.3389/fncel.2014.00233

Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellula... Read More about CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity.

A new mechanism of allostery in a G protein-coupled receptor dimer (2014)
Journal Article
Lane, J. R., Donthamsetti, P., Shonberg, J., Draper-Joyce, C. J., Dentry, S., Michino, M., …Christopoulos, A. (2014). A new mechanism of allostery in a G protein-coupled receptor dimer. Nature Chemical Biology, 10(9), 745-752. https://doi.org/10.1038/nchembio.1593

SB269652 is to our knowledge the first drug-like allosteric modulator of the dopamine D2 receptor (D2R), but it contains structural features associated with orthosteric D2R antagonists. Using a functional complementation system to control the identit... Read More about A new mechanism of allostery in a G protein-coupled receptor dimer.

Separate and combined effects of 21-day bed rest and hypoxic confinement on body composition (2014)
Journal Article
Debevec, T., Bali, T. C., Simpson, E. J., Macdonald, I. A., Eiken, O., & Mekjavic, I. B. (2014). Separate and combined effects of 21-day bed rest and hypoxic confinement on body composition. European Journal of Applied Physiology, 114(11), 2411-2425. https://doi.org/10.1007/s00421-014-2963-1

Purpose: This study tested the hypothesis that hypoxia exacerbates reductions in body mass observed during unloading. Methods: To discern the separate and combined effects of simulated microgravity and hypoxia, 11 healthy males underwent three 21-... Read More about Separate and combined effects of 21-day bed rest and hypoxic confinement on body composition.

Sexual reproduction of human fungal pathogens (2014)
Journal Article
Heitman, J., Carter, D. A., Dyer, P. S., & Soll, D. R. (in press). Sexual reproduction of human fungal pathogens. Cold Spring Harbor Perspectives in Medicine, 4(8), Article a019281. https://doi.org/10.1101/cshperspect.a019281

We review here recent advances in our understanding of sexual reproduction in fungal pathogens that commonly infect humans, including Candida albicans, Cryptococcus neoformans/gattii, and Aspergillus fumigatus. Where appropriate or relevant, we intro... Read More about Sexual reproduction of human fungal pathogens.

Development of an ex vivo porcine lung model for studying growth, virulence, and signaling of Pseudomonas aeruginosa (2014)
Journal Article
Harrison, F., Muruli, A., Higgins, S., & Diggle, S. P. (2014). Development of an ex vivo porcine lung model for studying growth, virulence, and signaling of Pseudomonas aeruginosa. Infection and Immunity, 82(8), https://doi.org/10.1128/IAI.01554-14

Research into chronic infection by bacterial pathogens, such as Pseudomonas aeruginosa, uses various in vitro and live host models. While these have increased our understanding of pathogen growth, virulence, and evolution, each model has certain limi... Read More about Development of an ex vivo porcine lung model for studying growth, virulence, and signaling of Pseudomonas aeruginosa.

Computational modeling of the effects of auditory nerve dysmyelination (2014)
Journal Article
Brown, A. M., & Hamann, M. (2014). Computational modeling of the effects of auditory nerve dysmyelination. Frontiers in Neuroanatomy, 8(73), https://doi.org/10.3389/fnana.2014.00073

Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to exami... Read More about Computational modeling of the effects of auditory nerve dysmyelination.

Risk-based learning games improve long-term retention of information among school pupils (2014)
Journal Article
Devonshire, I. M., Davis, J., Fairweather, S., Highfield, L., Thaker, C., Walsh, A., …Hathway, G. J. (2014). Risk-based learning games improve long-term retention of information among school pupils. PLoS ONE, 9(7), Article e103640. https://doi.org/10.1371/journal.pone.0103640

Risk heightens motivation and, if used appropriately, may have the potential to improve engagement in the classroom. We have developed a risk-based learning game for school pupils in order to test whether such learning games can improve later recall... Read More about Risk-based learning games improve long-term retention of information among school pupils.

Molecular characterization of the malaria vector Anopheles barbirostris van der Wulp in Sri Lanka (2014)
Journal Article
Gajapathy, K., Jude, P. J., Goodacre, S., Peiris, L. B., Ramasamy, R., & Surendran, S. N. (2014). Molecular characterization of the malaria vector Anopheles barbirostris van der Wulp in Sri Lanka. Parasites and Vectors, 7(1), Article 348. https://doi.org/10.1186/1756-3305-7-348

Background: Anopheles barbirostris is a vector of malaria in Sri Lanka. The taxon exists as a species complex in the Southeast Asian region. Previous studies using molecular markers suggest that there are more than 4 distinct clades within the An. ba... Read More about Molecular characterization of the malaria vector Anopheles barbirostris van der Wulp in Sri Lanka.

Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis (2014)
Journal Article

We describe a novel LC method for the simultaneous and quantitative profiling of 43 oxylipins including eicosanoids, endocannabinoids, and structurally related bioactive lipids with modified acyl groups. The LC-MS/MS method uses switching at a define... Read More about Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis.

Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport (2014)
Journal Article
Evans, R. D., Robinson, C., Briggs, D. A., Tooth, D. J., Ramalho, J. S., Cantero, M., …Hume, A. N. (2014). Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport. Current Biology, 24(15), 1743-1750. https://doi.org/10.1016/j.cub.2014.06.019

In animal cells, microtubule and actin tracks and their associated motors (dynein, kinesin, and myosin) are thought to regulate long- and short-range transport, respectively [1-8]. Consistent with this, microtubules extend from the perinuclear centro... Read More about Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport.

DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests (2014)
Journal Article
López-Gil, X., Amat-Roldan, I., Tudela, R., Castańé, A., Prats-Galino, A., Planas, A. M., …Soria, G. (2014). DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests. Frontiers in Aging Neuroscience, 6, Article 167. https://doi.org/10.3389/fnagi.2014.00167

The identification of biomarkers of vascular cognitive impairment is urgent for its early diagnosis. The aim of this study was to detect and monitor changes in brain structure and connectivity, and to correlate them with the decline in executive func... Read More about DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests.

Real-Time Monitoring of GPCR/cAMP Signalling by FRET and Single-Molecule Microscopy (2014)
Journal Article
Calebiro, D., Sungkaworn, T., & Maiellaro, I. (2014). Real-Time Monitoring of GPCR/cAMP Signalling by FRET and Single-Molecule Microscopy. Hormone and Metabolic Research, 46(12), 827-832. https://doi.org/10.1055/s-0034-1384523

G-protein-coupled receptors (GPCRs), located on the surface of virtually every cell in our organism, mediate the effects of many hormones and neurotransmitters. Although GPCRs have been extensively studied for more than 4 decades using pharmacologica... Read More about Real-Time Monitoring of GPCR/cAMP Signalling by FRET and Single-Molecule Microscopy.

Total synthesis of a eukaryotic chromosome: Redesigning and SCRaMbLE-ing yeast (2014)
Journal Article
Jovicevic, D., Blount, B. A., & Ellis, T. (2014). Total synthesis of a eukaryotic chromosome: Redesigning and SCRaMbLE-ing yeast. BioEssays, 36(9), 855-860. https://doi.org/10.1002/bies.201400086

A team of US researchers recently reported the design, assembly and in vivo functionality of a synthetic chromosome III (SynIII) for the yeast Saccharomyces cerevisiae. The synthetic chromosome was assembled bottom-up from DNA oligomers by teams of s... Read More about Total synthesis of a eukaryotic chromosome: Redesigning and SCRaMbLE-ing yeast.

Inferring mechanisms of copy number change from haplotype structures at the human DEFA1A3 locus (2014)
Journal Article
Black, H. A., Khan, F. F., Tyson, J., & Armour, J. A. (in press). Inferring mechanisms of copy number change from haplotype structures at the human DEFA1A3 locus. BMC Genomics, 15(614), https://doi.org/10.1186/1471-2164-15-614

Background: The determination of structural haplotypes at copy number variable regions can indicate the mechanisms responsible for changes in copy number, as well as explain the relationship between gene copy number and expression. However, obtaining... Read More about Inferring mechanisms of copy number change from haplotype structures at the human DEFA1A3 locus.