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Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment (2014)
Journal Article
Füchtemeier, M., Brinckmann, M. P., Foddis, M., Kunz, A., Po, C., Curato, C., …Farr, T. D. (2015). Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment. Journal of Cerebral Blood Flow and Metabolism, 35(3), https://doi.org/10.1038/jcbfm.2014.221

Our aims were to assess the spatiotemporal development of brain pathology in a mouse model of chronic hypoperfusion using magnetic resonance imaging (MRI), and to test whether the renin-angiotensin system (RAS) can offer therapeutic benefit. For the... Read More about Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment.

Potent and efficacious inhibition of CXCR2 signaling by biparatopic nanobodies combining two distinct modes of action (2014)
Journal Article
Bradley, M. E., Dombrecht, B., Manini, J., Willis, J., Vlerick, D., De Taeye, S., …Cromie, K. D. (2015). Potent and efficacious inhibition of CXCR2 signaling by biparatopic nanobodies combining two distinct modes of action. Molecular Pharmacology, 87(2), 251-262. https://doi.org/10.1124/mol.114.094821

Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics. Chemokines and chemokine receptors are key modulators in inflammatory diseases and malignancies. Here, we describe the identification and pharmacologic character... Read More about Potent and efficacious inhibition of CXCR2 signaling by biparatopic nanobodies combining two distinct modes of action.

Bioinformatics analysis of the serine and glycine pathway in cancer cells (2014)
Journal Article
Agostini, M., Antonov, A., Morello, M., Minieri, M., Melino, G., & Amelio, I. (2014). Bioinformatics analysis of the serine and glycine pathway in cancer cells. Oncotarget, 5(22), 11004-11013. https://doi.org/10.18632/oncotarget.2668

Serine and glycine are amino acids that provide the essential precursors for the synthesis of proteins, nucleic acids and lipids. Employing 3 subsequent enzymes, phosphoglycerate dehydrogenase (PHGDH), phosphoserine phosphatase (PSPH), phosphoserine... Read More about Bioinformatics analysis of the serine and glycine pathway in cancer cells.

The population genetic structure of Biomphalaria choanomphala in Lake Victoria, East Africa: implications for schistosomiasis transmission (2014)
Journal Article
Standley, C. J., Goodacre, S. L., Wade, C. M., & Stothard, J. R. (2014). The population genetic structure of Biomphalaria choanomphala in Lake Victoria, East Africa: implications for schistosomiasis transmission. Parasites and Vectors, 7(1), Article 524. https://doi.org/10.1186/s13071-014-0524-4

Background: The freshwater snail Biomphalaria acts as the intermediate host of Schistosoma mansoni, a globally important human parasite. Understanding the population structure of intermediate host species can elucidate transmission dynamics and assis... Read More about The population genetic structure of Biomphalaria choanomphala in Lake Victoria, East Africa: implications for schistosomiasis transmission.

Fructose-1,6-bisphosphate aldolase (FBA)-A conserved glycolytic enzyme with virulence functions in bacteria: 'Ill met by moonlight' (2014)
Journal Article
Shams, F., Oldfield, N. J., Wooldridge, K. G., & Turner, D. P. J. (2014). Fructose-1,6-bisphosphate aldolase (FBA)-A conserved glycolytic enzyme with virulence functions in bacteria: 'Ill met by moonlight'. Biochemical Society Transactions, 42(6), 1792-1795. https://doi.org/10.1042/BST20140203

© 2014 Biochemical Society. Moonlighting proteins constitute an intriguing class of multifunctional proteins. Metabolic enzymes and chaperones, which are often highly conserved proteins in bacteria, archaea and eukaryotic organisms, are among the mos... Read More about Fructose-1,6-bisphosphate aldolase (FBA)-A conserved glycolytic enzyme with virulence functions in bacteria: 'Ill met by moonlight'.

TAp73 promotes anabolism (2014)
Journal Article
Amelio, I., Antonov, A. A., Catani, M. V., Massoud, R., Bernassola, F., Knight, R. A., …Rufini, A. (2014). TAp73 promotes anabolism. Oncotarget, 5(24), 12820-12834. https://doi.org/10.18632/oncotarget.2667

Metabolic adaptation has emerged as a hallmark of cancer and a promising therapeutic target, as rapidly proliferating cancer cells adapt their metabolism increasing nutrient uptake and reorganizing metabolic fluxes to support biosynthesis. The transc... Read More about TAp73 promotes anabolism.

Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide (2014)
Journal Article
Wong, P. S., Roberts, R. E., & Randall, M. D. (2015). Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide. Pharmacological Research, 91, https://doi.org/10.1016/j.phrs.2014.11.001

Oxygenation with 95%O2is routinely used in organ bath studies. However, hyperoxia may affect tissueresponses, particularly in studies which involve reactive oxygen species (ROS). Here, the effects of theantioxidant, Tiron, were investigated under dif... Read More about Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide.

Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1 (2014)
Journal Article
Noyes, H., Githiori, J., Bradley, J. E., Kemp, S., & Behnke, J. M. (2015). Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1. Parasitology, 142(4), https://doi.org/10.1017/S0031182014001644

Resistance to infections with Heligmosomoides bakeri is associated with a significant quantitative trait locus (QTL–Hbnr1) on mouse chromosome 1 (MMU1). We exploited recombinant mice, with a segment of MMU1 from susceptible C57Bl/10 mice introgressed... Read More about Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1.

Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia (2014)
Journal Article
Mistry, H. D., Gill, C., Kurlak, L., Seed, P. T., Hestketh, J., Meplan, C., …Poston, L. (2015). Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia. Free Radical Biology and Medicine, 78, https://doi.org/10.1016/j.freeradbiomed.2014.10.580

Aims: Pre-eclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Deficiencies of specific micronutrient antioxidant activities associated with copper, selenium, zinc... Read More about Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia.

A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries (2014)
Journal Article
Mathewson, A. M., & Dunn, W. R. (2014). A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries. PLoS ONE, 9(11), Article e111977. https://doi.org/10.1371/journal.pone.0111977

The present study examined the hypothesis that potassium ions act as an endothelium-derived hyperpolarizing factor (EDHF) released in response to ACh in small mesenteric arteries displaying myogenic tone. Small mesenteric arteries isolated from rats... Read More about A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries.

Coenzyme A-transferase-independent butyrate re-assimilation in Clostridium acetobutylicum - evidence from a mathematical model (2014)
Journal Article
Millat, T., Voigt, C., Janssen, H., Cooksley, C. M., Winzer, K., Minton, N. P., …Wolkenhauer, O. (2014). Coenzyme A-transferase-independent butyrate re-assimilation in Clostridium acetobutylicum - evidence from a mathematical model. Applied Microbiology and Biotechnology, 98(21), https://doi.org/10.1007/s00253-014-5987-x

The hetero-dimeric CoA-transferase CtfA/B is believed to be crucial for the metabolic transition from acidogenesis to solventogenesis in Clostridium acetobutylicum as part of the industrial-relevant acetone-butanol-ethanol (ABE) fermentation. Here, t... Read More about Coenzyme A-transferase-independent butyrate re-assimilation in Clostridium acetobutylicum - evidence from a mathematical model.

A role for Rab27 in neutrophil chemotaxis and lung recruitment (2014)
Journal Article
Seabra, M. C., Rankin, S. M., Birrell, M. A., Furze, R. C., Singh, R. K., & Hume, A. N. (2014). A role for Rab27 in neutrophil chemotaxis and lung recruitment. BMC Cell Biology, 15(1), https://doi.org/10.1186/s12860-014-0039-z

© 2014 Singh et al. Background: Neutrophils are a critical part of the innate immune system. Their ability to migrate into infected or injured tissues precedes their role in microbial killing and clearance. We have previously shown that Rab27a can pr... Read More about A role for Rab27 in neutrophil chemotaxis and lung recruitment.

Type I interferon rapidly restricts infectious hepatitis C virus particle genesis (2014)
Journal Article
Meredith, L. W., Farquhar, M. J., Tarr, A. W., & McKeating, J. A. (2014). Type I interferon rapidly restricts infectious hepatitis C virus particle genesis. Hepatology, 60(6), https://doi.org/10.1002/hep.27333

Interferon-alpha (IFNα) has been used to treat chronic hepatitis C virus (HCV) infection for over 20 years with varying efficacy, depending on the infecting viral genotype. The mechanism of action of IFNα is not fully understood, but is thought to ta... Read More about Type I interferon rapidly restricts infectious hepatitis C virus particle genesis.

Periaqueductal grey cyclooxygenase-dependent facilitation of C-nociceptive drive and encoding in dorsal horn neurons in the rat (2014)
Journal Article
Lianne Leith, J., Wilson, A. W., You, H. J., Lumb, B. M., & Donaldson, L. F. (2014). Periaqueductal grey cyclooxygenase-dependent facilitation of C-nociceptive drive and encoding in dorsal horn neurons in the rat. Journal of Physiology, 592(22), 5093-5107. https://doi.org/10.1113/jphysiol.2014.275909

© 2014 The Authors. The experience of pain is strongly affected by descending control systems originating in the brainstem ventrolateral periaqueductal grey (VL-PAG), which control the spinal processing of nociceptive information. A- and C-fibre noci... Read More about Periaqueductal grey cyclooxygenase-dependent facilitation of C-nociceptive drive and encoding in dorsal horn neurons in the rat.

Lichen response to ammonia deposition defines the footprint of a penguin rookery (2014)
Journal Article
Crittenden, P., Scrimgeour, C., Minnullina, G., Sutton, M., Tang, Y., & Theobald, M. (2015). Lichen response to ammonia deposition defines the footprint of a penguin rookery. Biogeochemistry, 122(2-3), https://doi.org/10.1007/s10533-014-0042-7

Ammonia volatilized from penguin rookeries is a major nitrogen source in Antarctic coastal terrestrial ecosystems. However, the spatial extent of ammonia dispersion from rookeries and its impacts have not been quantified previously. We measured ammon... Read More about Lichen response to ammonia deposition defines the footprint of a penguin rookery.

Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B′ (2014)
Journal Article
Procopiou, G., Aggarwal, P., Newton, A. F., Richards, D., Mellor, I. R., Harbottle, G., & Stockman, R. A. (2014). Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B′. Chemical Communications, 50(97), 15355-15357. https://doi.org/10.1039/c4cc07287a

© 2014 The Royal Society of Chemistry. The first total synthesis of myrmicine ant alkaloid 5-epi-cis-275B′ (4) is presented. A tandem cyclisation established the entire core of the structure in a single transformation as well as the required 2,5-anti... Read More about Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B′.