Fructose-1,6-bisphosphate aldolase (FBA)-A conserved glycolytic enzyme with virulence functions in bacteria: 'Ill met by moonlight'

Shams, Fariza; Oldfield, Neil J.; Wooldridge, Karl G.; Turner, David P J

Abstract

© 2014 Biochemical Society. Moonlighting proteins constitute an intriguing class of multifunctional proteins. Metabolic enzymes and chaperones, which are often highly conserved proteins in bacteria, archaea and eukaryotic organisms, are among the most commonly recognized examples of moonlighting proteins. Fructose-1,6-bisphosphate aldolase (FBA) is an enzyme involved in the Embden-Meyerhof-Parnas (EMP) glycolytic pathway and in gluconeogenesis. Increasingly, it is also recognized that FBA has additional functions beyond its housekeeping role in central metabolism. In the present review, we summarize the current knowledge of the moonlighting functions of FBA in bacteria.

Citation

Shams, F., Oldfield, N. J., Wooldridge, K. G., & Turner, D. P. J. (2014). Fructose-1,6-bisphosphate aldolase (FBA)-A conserved glycolytic enzyme with virulence functions in bacteria: 'Ill met by moonlight'. Biochemical Society Transactions, 42(6), 1792-1795. https://doi.org/10.1042/BST20140203

• Journal Article Type: Article
• Acceptance Date: Aug 1, 2014
• Online Publication Date: Nov 17, 2014
• Publication Date: Dec 1, 2014
• Deposit Date: Aug 2, 2022
• Journal: Biochemical Society Transactions
• Print ISSN: 0300-5127
• Electronic ISSN: 1470-8752
• Publisher: Portland Press
• Peer Reviewed: Peer Reviewed
• Volume: 42
• Issue: 6
• Pages: 1792-1795
• DOI: https://doi.org/10.1042/BST20140203
• Public URL: https://nottingham-repository.worktribe.com/output/3129775
• Publisher URL: https://portlandpress.com/biochemsoctrans/article-abstract/42/6/1792/65113/Fructose-1-6-bisphosphate-aldolase-FBA-a-conserved