All Outputs (4)

Sensory neuronal sensitisation occurs through HMGB-1/RAGE and TRPV1 in high glucose conditions (2018)
Journal Article
Bestall, S. M., Hulse, R. P., Blackley, Z., Swift, M., Ved, N., Paton, K., …Donaldson, L. F. (in press). Sensory neuronal sensitisation occurs through HMGB-1/RAGE and TRPV1 in high glucose conditions. Journal of Cell Science, Article jcs.215939. https://doi.org/10.1242/jcs.215939

Many potential causes for painful diabetic neuropathy have been proposed including actions of cytokines and growth factors. High mobility group protein B1 (HMGB1) is a RAGE agonist, increased in diabetes, that contributes to pain by modulating periph... Read More about Sensory neuronal sensitisation occurs through HMGB-1/RAGE and TRPV1 in high glucose conditions.

Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators (2018)
Journal Article
Bates, D. O., Beazley-Long, N., Benest, A. V., Ye, X., Ved, N., Hulse, R. P., …Foster, R. R. (2018). Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators. Comprehensive Physiology, 8(3), 955-979. https://doi.org/10.1002/cphy.c170015

The vascular endothelial growth factor (VEGF) family of proteins are key regulators of physiological systems. Originally linked with endothelial function, they have since become understood to be principal regulators of multiple tissues, both through... Read More about Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators.

Diabetes-induced microvascular complications at the level of the spinal cord: a contributing factor in diabetic neuropathic pain (2018)
Journal Article
Ved, N., Da Vitoria Lobo, M., Bestall, S. M., Vidueira, C., Beazley-Long, N., Ballmer-Hofer, K., …Hulse, R. P. (2018). Diabetes-induced microvascular complications at the level of the spinal cord: a contributing factor in diabetic neuropathic pain. Journal of Physiology, 596(16), 3675-3693. https://doi.org/10.1113/JP275067

Abnormalities of neurovascular interactions within the central nervous system of diabetic patients is associated with the onset of many neurological disease states. However, to date, the link between the neurovascular network within the spinal cord a... Read More about Diabetes-induced microvascular complications at the level of the spinal cord: a contributing factor in diabetic neuropathic pain.

VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis (2018)
Journal Article
Beazley-Long, N., Moss, C. E., Ashby, W. R., Bestall, S. M., Almahasneh, F., Durrant, A. M., …Donaldson, L. F. (2018). VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis. Brain, Behavior, and Immunity, 74, 49-67. https://doi.org/10.1016/j.bbi.2018.03.012

Chronic pain can develop in response to conditions such as inflammatory arthritis. The central mechanisms underlying the development and maintenance of chronic pain in humans are not well elucidated although there is evidence for a role of microglia... Read More about VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis.