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A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries (2014)
Journal Article
Mathewson, A. M., & Dunn, W. R. (2014). A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries. PLoS ONE, 9(11), Article e111977. https://doi.org/10.1371/journal.pone.0111977

The present study examined the hypothesis that potassium ions act as an endothelium-derived hyperpolarizing factor (EDHF) released in response to ACh in small mesenteric arteries displaying myogenic tone. Small mesenteric arteries isolated from rats... Read More about A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries.

Coenzyme A-transferase-independent butyrate re-assimilation in Clostridium acetobutylicum - evidence from a mathematical model (2014)
Journal Article
Millat, T., Voigt, C., Janssen, H., Cooksley, C. M., Winzer, K., Minton, N. P., …Wolkenhauer, O. (2014). Coenzyme A-transferase-independent butyrate re-assimilation in Clostridium acetobutylicum - evidence from a mathematical model. Applied Microbiology and Biotechnology, 98(21), https://doi.org/10.1007/s00253-014-5987-x

The hetero-dimeric CoA-transferase CtfA/B is believed to be crucial for the metabolic transition from acidogenesis to solventogenesis in Clostridium acetobutylicum as part of the industrial-relevant acetone-butanol-ethanol (ABE) fermentation. Here, t... Read More about Coenzyme A-transferase-independent butyrate re-assimilation in Clostridium acetobutylicum - evidence from a mathematical model.

A role for Rab27 in neutrophil chemotaxis and lung recruitment (2014)
Journal Article
Seabra, M. C., Rankin, S. M., Birrell, M. A., Furze, R. C., Singh, R. K., & Hume, A. N. (2014). A role for Rab27 in neutrophil chemotaxis and lung recruitment. BMC Cell Biology, 15(1), https://doi.org/10.1186/s12860-014-0039-z

© 2014 Singh et al. Background: Neutrophils are a critical part of the innate immune system. Their ability to migrate into infected or injured tissues precedes their role in microbial killing and clearance. We have previously shown that Rab27a can pr... Read More about A role for Rab27 in neutrophil chemotaxis and lung recruitment.

STAT3 paradoxically stimulates ??catenin expression but inhibits ??catenin function (2014)
Journal Article
Ibrahem, S., Al‐Ghamdi, S., Baloch, K., Muhammad, B., Fadhil, W., Jackson, D., …Ilyas, M. (2014). STAT3 paradoxically stimulates β‐catenin expression but inhibits β‐catenin function. International Journal of Experimental Pathology, 95(6), 392-400. https://doi.org/10.1111/iep.12102

Wnt signalling and the signal transducer and activator of transcription 3 (STAT3) are oncogenic signalling pathways which are deregulated in colorectal cancer (CRC). Here we investigated the interaction of these two pathways. Firstly, we investigated... Read More about STAT3 paradoxically stimulates ??catenin expression but inhibits ??catenin function.

Type I interferon rapidly restricts infectious hepatitis C virus particle genesis (2014)
Journal Article
Meredith, L. W., Farquhar, M. J., Tarr, A. W., & McKeating, J. A. (2014). Type I interferon rapidly restricts infectious hepatitis C virus particle genesis. Hepatology, 60(6), https://doi.org/10.1002/hep.27333

Interferon-alpha (IFNα) has been used to treat chronic hepatitis C virus (HCV) infection for over 20 years with varying efficacy, depending on the infecting viral genotype. The mechanism of action of IFNα is not fully understood, but is thought to ta... Read More about Type I interferon rapidly restricts infectious hepatitis C virus particle genesis.

Periaqueductal grey cyclooxygenase-dependent facilitation of C-nociceptive drive and encoding in dorsal horn neurons in the rat (2014)
Journal Article
Lianne Leith, J., Wilson, A. W., You, H. J., Lumb, B. M., & Donaldson, L. F. (2014). Periaqueductal grey cyclooxygenase-dependent facilitation of C-nociceptive drive and encoding in dorsal horn neurons in the rat. Journal of Physiology, 592(22), 5093-5107. https://doi.org/10.1113/jphysiol.2014.275909

© 2014 The Authors. The experience of pain is strongly affected by descending control systems originating in the brainstem ventrolateral periaqueductal grey (VL-PAG), which control the spinal processing of nociceptive information. A- and C-fibre noci... Read More about Periaqueductal grey cyclooxygenase-dependent facilitation of C-nociceptive drive and encoding in dorsal horn neurons in the rat.

Lichen response to ammonia deposition defines the footprint of a penguin rookery (2014)
Journal Article
Crittenden, P., Scrimgeour, C., Minnullina, G., Sutton, M., Tang, Y., & Theobald, M. (2015). Lichen response to ammonia deposition defines the footprint of a penguin rookery. Biogeochemistry, 122(2-3), https://doi.org/10.1007/s10533-014-0042-7

Ammonia volatilized from penguin rookeries is a major nitrogen source in Antarctic coastal terrestrial ecosystems. However, the spatial extent of ammonia dispersion from rookeries and its impacts have not been quantified previously. We measured ammon... Read More about Lichen response to ammonia deposition defines the footprint of a penguin rookery.

Origins of major archaeal clades correspond to gene acquisitions from bacteria (2014)
Journal Article
Nelson-Sathi, S., Sousa, F. L., Roettger, M., Lozada-Chavez, N., Thiergart, T., Janssen, A., …Martin, W. F. (2015). Origins of major archaeal clades correspond to gene acquisitions from bacteria. Nature, 517(7532), 77-80. https://doi.org/10.1038/nature13805

The mechanisms that underlie the origin of major prokaryotic groups are poorly understood. In principle, the origin of both species and higher taxa among prokaryotes should entail similar mechanisms--ecological interactions with the environment paire... Read More about Origins of major archaeal clades correspond to gene acquisitions from bacteria.

Effects of NAD at purine receptors in isolated blood vessels (2014)
Journal Article
Alefishat, E., Alexander, S. P., & Ralevic, V. (2015). Effects of NAD at purine receptors in isolated blood vessels. Purinergic Signalling, 11(1), https://doi.org/10.1007/s11302-014-9428-1

Nicotinamide adenine dinucleotide (NAD) belongs to the family of naturally occurring adenine dinucleotides, best known for their various intracellular roles. However, there is evidence that they can also be released from cells to act as novel extrace... Read More about Effects of NAD at purine receptors in isolated blood vessels.

Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B? (2014)
Journal Article
Procopiou, G., Aggarwal, P., Newton, A. F., Richards, D., Mellor, I. R., Harbottle, G., & Stockman, R. A. (2014). Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B?. Chemical Communications, 50(97), 15355-15357. https://doi.org/10.1039/c4cc07287a

© 2014 The Royal Society of Chemistry. The first total synthesis of myrmicine ant alkaloid 5-epi-cis-275B′ (4) is presented. A tandem cyclisation established the entire core of the structure in a single transformation as well as the required 2,5-anti... Read More about Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B?.

Development and validation of protein microarray technology for simultaneous inflammatory mediator detection in human sera (2014)
Journal Article
Selvarajah, S., Negm, O. H., Hamed, M. R., Tubby, C., Todd, I., Tighe, P. J., …Fairclough, L. C. (2014). Development and validation of protein microarray technology for simultaneous inflammatory mediator detection in human sera. Mediators of Inflammation, 2014, 1-12. https://doi.org/10.1155/2014/820304

© 2014 Senthooran Selvarajah et al. Biomarkers, including cytokines, can help in the diagnosis, prognosis, and prediction of treatment response across a wide range of disease settings. Consequently, the recent emergence of protein microarray technolo... Read More about Development and validation of protein microarray technology for simultaneous inflammatory mediator detection in human sera.

Molecular Evidence for Cryptic Speciation in the Cyclophorus fulguratus (Pfeiffer, 1854) Species Complex (Caenogastropoda: Cyclophoridae) with Description of New Species. (2014)
Journal Article
Nantarat, N., WADE, C., Jeratthitikul, E., Sutcharit, C., & Panha, S. (2014). Molecular Evidence for Cryptic Speciation in the Cyclophorus fulguratus (Pfeiffer, 1854) Species Complex (Caenogastropoda: Cyclophoridae) with Description of New Species. PLoS ONE, 9(10), Article e109785. https://doi.org/10.1371/journal.pone.0109785

A high degree of intraspecific variation, both genetic and in shell morphology, of the operculate land snail Cyclophorus fulguratus (Pfeiffer, 1854) suggests that its classification as a single species warrants reconsideration. We sequenced two nucle... Read More about Molecular Evidence for Cryptic Speciation in the Cyclophorus fulguratus (Pfeiffer, 1854) Species Complex (Caenogastropoda: Cyclophoridae) with Description of New Species..

Surgical materials: Current challenges and nano-enabled solutions (2014)
Journal Article
Annabi, N., Tamayol, A., Shin, S. R., Ghaemmaghami, A. M., Peppas, N. A., & Khademhosseini, A. (2014). Surgical materials: Current challenges and nano-enabled solutions. Nano Today, 9(5), 574-589. https://doi.org/10.1016/j.nantod.2014.09.006

© 2014 Elsevier Ltd. All rights reserved. Surgical adhesive biomaterials have emerged as substitutes to sutures and staples in many clinical applications. Nano-enabled materials containing nanoparticles or having a distinct nanotopography have been u... Read More about Surgical materials: Current challenges and nano-enabled solutions.

Deciphering the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis (2014)
Journal Article
Alqahtani, F. Y. S., Mahdavi, J., Wheldon, L. M., Vassey, M., Pirinccioglu, N., Royer, P., …Ala'Aldeen, D. A. (2014). Deciphering the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis. Open Biology, 4(10), Article 140053. https://doi.org/10.1098/rsob.140053

The non-integrin laminin receptor (LAMR1/RPSA) and galectin-3 (Gal-3) are multi-functional host molecules with roles in diverse pathological processes, particularly of infectious or oncogenic origins. Using bimolecular fluorescence complementation an... Read More about Deciphering the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis.

Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations (2014)
Journal Article
Sawbridge, J. L., Qureshi, H. K., Boyd, M. J., & Brown, A. M. (2014). Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations. Advances in Physiology Education, 38(3), 239-245. https://doi.org/10.1152/advan.00036.2014

The ability to understand and implement calculations required for molarity and dilution computations that are routinely undertaken in the laboratory are essential skills that should be possessed by all students entering an undergraduate Life Sciences... Read More about Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations.