All Outputs (70)

Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism (2022)
Journal Article
Wood, J., Abdelrazig, S., Evseev, S., Ortori, C., Castellanos-Uribe, M., May, S. T., …Rahman, R. (2022). Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism. Cancers, 14(16), Article 3873. https://doi.org/10.3390/cancers14163873

Poor outcomes associated with diffuse high-grade gliomas occur in both adults and children, despite substantial progress made in the molecular characterisation of the disease. Targeting the metabolic requirements of cancer cells represents an alterna... Read More about Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism.

Root angle is controlled by EGT1in cereal crops employing anantigravitropic mechanism (2022)
Journal Article
Fusi, R., Rosignoli, S., Lou, H., Sangiorgi, G., Bovina, R., Pattem, J. K., …Salvi, S. (2022). Root angle is controlled by EGT1in cereal crops employing anantigravitropic mechanism. Proceedings of the National Academy of Sciences,

Root angle in crops represents a key trait for efficient capture of soil resources. Root angle is determined by competing gravitropic versus anti-gravitropic offset (AGO) mechanisms. Here we report a new root angle regulatory gene termed ENHANCED GRA... Read More about Root angle is controlled by EGT1in cereal crops employing anantigravitropic mechanism.

Cereal grain mineral micronutrient and soil chemistry data from GeoNutrition surveys in Ethiopia and Malawi (2022)
Other
Kumssa, D. B., Mossa, A. W., Amede, T., Ander, E. L., Bailey, E. H., Botoman, L., …Nalivata, P. C. (2022). Cereal grain mineral micronutrient and soil chemistry data from GeoNutrition surveys in Ethiopia and Malawi

The dataset comprises primary data for the concentration of 29 mineral micronutrients in cereal grains and up to 84 soil chemistry properties from GeoNutrition project surveys in Ethiopia and Malawi. The work provided insights on geospatial variation... Read More about Cereal grain mineral micronutrient and soil chemistry data from GeoNutrition surveys in Ethiopia and Malawi.

Modelling reveals post-transcriptional regulation of GA metabolism enzymes in response to drought and cold (2022)
Journal Article
Band, L. R., Nelissen, H., Preston, S. P., Rymen, B., Prinsen, E., Abd Elgawad, H., & Beemster, G. T. S. (2022). Modelling reveals post-transcriptional regulation of GA metabolism enzymes in response to drought and cold. Proceedings of the National Academy of Sciences, 119(31), Article e2121288119. https://doi.org/10.1073/pnas.2121288119

The hormone gibberellin (GA) controls plant growth and regulates growth responses to environmental stress. In monocotyledonous leaves, GA controls growth by regulating division-zone size. We used a systems approach to investigate the establishment of... Read More about Modelling reveals post-transcriptional regulation of GA metabolism enzymes in response to drought and cold.

The potential of spot urine as a biomarker for zinc assessment in Malawian children and adults (2022)
Journal Article
Likoswe, B. H., Lark, R. M., Phuka, J., Maleta, K., Joy, E., & Lowe, N. M. (2022). The potential of spot urine as a biomarker for zinc assessment in Malawian children and adults. Frontiers in Nutrition, 9, Article 890209. https://doi.org/10.3389/fnut.2022.890209

Population-level assessment of zinc deficiency remains a challenge due to the lack of suitable biomarkers. Spot urinary zinc concentration (UZC) has the potential to provide information on population zinc status in large-scale surveys, but there is n... Read More about The potential of spot urine as a biomarker for zinc assessment in Malawian children and adults.

Ethylene inhibits rice root elongation in compacted soil via ABA- and auxin-mediated mechanisms (2022)
Journal Article
Huang, G., Kilic, A., Karady, M., Zhang, J., Mehra, P., Song, X., …Pandey, B. K. (2022). Ethylene inhibits rice root elongation in compacted soil via ABA- and auxin-mediated mechanisms. Proceedings of the National Academy of Sciences, 119(30), Article e2201072119. https://doi.org/10.1073/pnas.2201072119

Soil compaction represents a major agronomic challenge, inhibiting root elongation and impacting crop yields. Roots use ethylene to sense soil compaction as the restricted air space causes this gaseous signal to accumulate around root tips. Ethylene... Read More about Ethylene inhibits rice root elongation in compacted soil via ABA- and auxin-mediated mechanisms.

Linkages between soil, crop, livestock, and human selenium status in Sub-Saharan Africa: a scoping review (2022)
Journal Article
Mutonhodza, B., Joy, E. J., Bailey, E. H., Lark, M. R., Kangara, M. G., Broadley, M. R., …Chopera, P. (2022). Linkages between soil, crop, livestock, and human selenium status in Sub-Saharan Africa: a scoping review. International Journal of Food Science and Technology, 57(10), 6336-6349. https://doi.org/10.1111/ijfs.15979

Selenium (Se) is essential for human health, however, data on population Se status and agriculture-nutrition-health linkages are limited in sub-Saharan Africa (SSA). The scoping review aims to identify linkages between Se in soils/crops, dietary Se i... Read More about Linkages between soil, crop, livestock, and human selenium status in Sub-Saharan Africa: a scoping review.

Assessing the potential of using the Langdon 5D(5B) substitution line for the introgression of Aegilops tauschii into durum wheat (2022)
Journal Article
Othmeni, M., Grewal, S., Walker, J., Yang, C., King, I. P., & King, J. (2022). Assessing the potential of using the Langdon 5D(5B) substitution line for the introgression of Aegilops tauschii into durum wheat. Frontiers in Plant Science, 13, Article 927728. https://doi.org/10.3389/fpls.2022.927728

Aegilops tauschii, the D-genome donor of hexaploid wheat, provides a source of genetic variation that could be used for tetraploid (durum) wheat improvement. In addition to the genes for wheat quality on the D-genome, which differentiate between brea... Read More about Assessing the potential of using the Langdon 5D(5B) substitution line for the introgression of Aegilops tauschii into durum wheat.

The botanical education extinction and the fall of plant awareness (2022)
Journal Article
Stroud, S., Fennell, M., Mitchley, J., Lydon, S., Peacock, J., & Bacon, K. L. (2022). The botanical education extinction and the fall of plant awareness. Ecology and Evolution, 12(7), Article e9019. https://doi.org/10.1002/ece3.9019

Civilization is dependent upon plants for survival. Plants permeate our every moment and our relationship with them will dictate how we will manage the threats of climate change and ecological collapse defining the Anthropocene. Yet, despite the sign... Read More about The botanical education extinction and the fall of plant awareness.

Sub-sampling a large physical soil archive for additional analyses to support spatial mapping; a pre-registered experiment in the Southern Nations, Nationalities, and Peoples Region (SNNPR) of Ethiopia (2022)
Journal Article
Alemu, R., Gelaw, A. M., Gashu, D., Tafere, K., Mossa, A. W., Bailey, E., …Lark, R. M. (2022). Sub-sampling a large physical soil archive for additional analyses to support spatial mapping; a pre-registered experiment in the Southern Nations, Nationalities, and Peoples Region (SNNPR) of Ethiopia. Geoderma, 424, Article 116013. https://doi.org/10.1016/j.geoderma.2022.116013

The value of physical archives of soil material from field sampling activities has been widely recognized. If we want to use archive material for new destructive analyses to support a task, such as spatial mapping, then an efficient sub-sampling stra... Read More about Sub-sampling a large physical soil archive for additional analyses to support spatial mapping; a pre-registered experiment in the Southern Nations, Nationalities, and Peoples Region (SNNPR) of Ethiopia.

Selenium Concentration in Cattle Serum and Fodder from Two Areas in Ethiopia with Contrasting Human Selenium Concentration (2022)
Journal Article
Hailu, K., Gashu, D., Joy, E. J. M., Alonso, S., Gizaw, S., Gameda, S., …Broadley, M. R. (2022). Selenium Concentration in Cattle Serum and Fodder from Two Areas in Ethiopia with Contrasting Human Selenium Concentration. Frontiers in Bioscience-Landmark, 27(7), Article 200. https://doi.org/10.31083/j.fbl2707200

INTRODUCTION: Selenium (Se) is an essential mineral for livestock health and productivity. In cattle, Se deficiency is associated with delayed conception, growth retardation, and increased morbidity and mortality. METHODS: We conducted a survey of ca... Read More about Selenium Concentration in Cattle Serum and Fodder from Two Areas in Ethiopia with Contrasting Human Selenium Concentration.

Limited Supply of Protein and Lysine Is Prevalent among the Poorest Households in Malawi and Exacerbated by Low Protein Quality (2022)
Journal Article
Muleya, M., Tang, K., Broadley, M. R., Salter, A. M., & Joy, E. J. M. (2022). Limited Supply of Protein and Lysine Is Prevalent among the Poorest Households in Malawi and Exacerbated by Low Protein Quality. Nutrients, 14(12), Article 2430. https://doi.org/10.3390/nu14122430

We estimated dietary supplies of total and available protein and indispensable amino acids (IAAs) and predicted the risk of deficiency in Malawi using Household Consumption and Expenditure Survey data. More than half of dietary protein was derived fr... Read More about Limited Supply of Protein and Lysine Is Prevalent among the Poorest Households in Malawi and Exacerbated by Low Protein Quality.

An oxygen-sensing mechanism for angiosperm adaptation to altitude (2022)
Journal Article
Abbas, M., Sharma, G., Dambire, C., Marquez, J., Alonso-Blanco, C., Proaño, K., & Holdsworth, M. J. (2022). An oxygen-sensing mechanism for angiosperm adaptation to altitude. Nature, https://doi.org/10.1038/s41586-022-04740-y

Flowering plants (angiosperms) can grow at extreme altitudes, and have been observed growing as high as 6,400 metres above sea level1,2; however, the molecular mechanisms that enable plant adaptation specifically to altitude are unknown. One distingu... Read More about An oxygen-sensing mechanism for angiosperm adaptation to altitude.

Introgression of the Triticum timopheevii Genome Into Wheat Detected by Chromosome-Specific Kompetitive Allele Specific PCR Markers (2022)
Journal Article
King, J., Grewal, S., Othmeni, M., Coombes, B., Yang, C., Walter, N., …King, I. (2022). Introgression of the Triticum timopheevii Genome Into Wheat Detected by Chromosome-Specific Kompetitive Allele Specific PCR Markers. Frontiers in Plant Science, 13, Article 919519. https://doi.org/10.3389/fpls.2022.919519

Triticum timopheevii (2n = 28, AtAtGG) is a tetraploid wild relative species with great potential to increase the genetic diversity of hexaploid wheat Triticum aestivum (2n = 42, AABBDD) for various important agronomic traits. A breeding scheme that... Read More about Introgression of the Triticum timopheevii Genome Into Wheat Detected by Chromosome-Specific Kompetitive Allele Specific PCR Markers.

Folate Deficiency Is Spatially Dependent and Associated with Local Farming Systems among Women in Ethiopia (2022)
Journal Article
Sisay, B. G., Tamirat, H., Sandalinas, F., Joy, E. J., Zerfu, D., Belay, A., …Gashu, D. (2022). Folate Deficiency Is Spatially Dependent and Associated with Local Farming Systems among Women in Ethiopia. Current Developments in Nutrition, 6(5), Article nzac088. https://doi.org/10.1093/cdn/nzac088

Background: Folate is essential for the synthesis and integrity of DNA, normal cell formation, and body growth. Folate deficiency among women of reproductive age (WRA) increases the risk of poor birth outcomes including neural tube defect (NTD)-affec... Read More about Folate Deficiency Is Spatially Dependent and Associated with Local Farming Systems among Women in Ethiopia.

Sporophytic control of pollen meiotic progression is mediated by tapetum expression of ABORTED MICROSPORES (2022)
Journal Article
Tidy, A. C., Ferjentsikova, I., Vizcay-Barrena, G., Liu, B., Yin, W., Higgins, J. D., …Wilson, Z. A. (2022). Sporophytic control of pollen meiotic progression is mediated by tapetum expression of ABORTED MICROSPORES. Journal of Experimental Botany, 73(16), 5543-5558. https://doi.org/10.1093/jxb/erac225

Pollen development is dependent on the tapetum, a sporophytic anther cell layer surrounding the microspores that functions in pollen wall formation but is also essential for meiosis-associated development. There is clear evidence of crosstalk and co-... Read More about Sporophytic control of pollen meiotic progression is mediated by tapetum expression of ABORTED MICROSPORES.

Sunflecks in the upper canopy: dynamics of light-use efficiency in sun and shade leaves of Fagus sylvatica (2022)
Journal Article
Durand, M., Stangl, Z. R., Salmon, Y., Burgess, A. J., Murchie, E. H., & Robson, T. M. (2022). Sunflecks in the upper canopy: dynamics of light-use efficiency in sun and shade leaves of Fagus sylvatica. New Phytologist, 235(4), 1365-1378. https://doi.org/10.1111/nph.18222

Sunflecks are transient patches of direct radiation that provide a substantial proportion of the daily irradiance to leaves in the lower canopy. In this position, faster photosynthetic induction would allow for higher sunfleck-use efficiency, as is c... Read More about Sunflecks in the upper canopy: dynamics of light-use efficiency in sun and shade leaves of Fagus sylvatica.

Soil and landscape factors influence geospatial variation in maize grain zinc concentration in Malawi (2022)
Journal Article
Botoman, L., Chagumaira, C., Mossa, A. W., Amede, T., Ander, E. L., Bailey, E. H., …Nalivata, P. C. (2022). Soil and landscape factors influence geospatial variation in maize grain zinc concentration in Malawi. Scientific Reports, 12(1), Article 7986. https://doi.org/10.1038/s41598-022-12014-w

Dietary zinc (Zn) deficiency is widespread globally, and in particular among people in sub-Saharan Africa (SSA). In Malawi, dietary sources of Zn are dominated by maize and spatially dependent variation in grain Zn concentration, which will affect di... Read More about Soil and landscape factors influence geospatial variation in maize grain zinc concentration in Malawi.

Genetic diversity analysis and marker-trait associations in Amaranthus species (2022)
Journal Article
Jamalluddin, N., Massawe, F. J., Mayes, S., Ho, W. K., & Symonds, R. C. (2022). Genetic diversity analysis and marker-trait associations in Amaranthus species. PLoS ONE, 17(5), Article e0267752. https://doi.org/10.1371/journal.pone.0267752

Amaranth (Amaranthus spp.) is a highly nutritious, underutilized vegetable and pseudo-cereal crop. It possesses diverse abiotic stress tolerance traits, is genetically diverse and highly phenotypically plastic, making it an ideal crop to thrive in a... Read More about Genetic diversity analysis and marker-trait associations in Amaranthus species.

Allelic shift in cis-elements of the transcription factor RAP2.12 underlies adaptation associated with humidity in Arabidopsis thaliana (2022)
Journal Article
Lou, S., Guo, X., Liu, L., Song, Y., Zhang, L., Jiang, Y., …Liu, J. (2022). Allelic shift in cis-elements of the transcription factor RAP2.12 underlies adaptation associated with humidity in Arabidopsis thaliana. Science Advances, 8(18), Article eabn8281. https://doi.org/10.1126/sciadv.abn8281

Populations of widespread species are usually geographically distributed through contrasting stresses, but underlying genetic mechanisms controlling this adaptation remain largely unknown. Here, we show that in Arabidopsis thaliana, allelic changes i... Read More about Allelic shift in cis-elements of the transcription factor RAP2.12 underlies adaptation associated with humidity in Arabidopsis thaliana.