Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer

Harris, Anna E.; Metzler, Veronika M.; Lothion-Roy, Jennifer; Varun, Dhruvika; Woodcock, Corinne L.; Haigh, Daisy B.; Endeley, Chantelle; Haque, Maria; Toss, Michael S.; Alsaleem, Mansour; Persson, Jenny L.; Gudas, Lorraine J.; Rakha, Emad; Robinson, Brian D.; Khani, Francesca; Martin, Laura M.; Moyer, Jenna E.; Brownlie, Juliette; Madhusudan, Srinivasan; Allegrucci, Cinzia; James, Victoria H.; Rutland, Catrin S.; Fray, Rupert G.; Ntekim, Atara; de Brot, Simone; Mongan, Nigel P.; Jeyapalan, Jennie N.

doi:10.3389/fendo.2022.1006101

All Outputs (2)

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer (2023)
Journal Article
Lothion-Roy, J., Haigh, D. B., Harris, A. E., Metzler, V. M., Alsaleem, M., Toss, M. S., …Woodcock, C. L. (2023). Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. Frontiers in Genetics, 13, Article 1096071. https://doi.org/10.3389/fgene.2022.1096071

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are... Read More about Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.

Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer (2022)
Journal Article
Harris, A. E., Metzler, V. M., Lothion-Roy, J., Varun, D., Woodcock, C. L., Haigh, D. B., …Jeyapalan, J. N. (2022). Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Frontiers in Endocrinology, 13, Article 1006101. https://doi.org/10.3389/fendo.2022.1006101

Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bic... Read More about Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer.