All Outputs (5)

Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes (2022)
Journal Article
White, K., Aldurdunji, M., Harris, J., Ortori, C., & Paine, S. (2022). Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes. Pharmacology Research and Perspectives, 10(6), Article e01031. https://doi.org/10.1002/prp2.1031

The translation of new injectable anaesthetic drugs from rodent to humans remains slow, despite the realisation that reliance on the volatile agents is unsustainable from an environmental perspective. The aim of this study was to investigate the infl... Read More about Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes.

Clinical measurements performed during alfaxalone total intravenous anaesthesia for radiography and neurophysiological investigations in dogs (2019)
Journal Article
Harris, J. R., Goff, M., Jenkins, H., Harris, J., Knowles, T. B., Lascelles, B. D., …Murrell, J. C. (2019). Clinical measurements performed during alfaxalone total intravenous anaesthesia for radiography and neurophysiological investigations in dogs. Veterinary Anaesthesia and Analgesia, 46(4), 483-487. https://doi.org/10.1016/j.vaa.2018.11.010

Objective: To describe clinically relevant, physiological measurements collected during a 3- hour duration alfaxalone total intravenous anaesthesia. Study design: Case series. Animals: A total of 112 client-owned middle aged or older dogs. Methods... Read More about Clinical measurements performed during alfaxalone total intravenous anaesthesia for radiography and neurophysiological investigations in dogs.

Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis (2018)
Journal Article
Murrell, J. C., Whay, H. R., Mendl, M., Lascelles, B. D. X., Hunt, J. R., Hunt, J. R., …Murrell, J. C. (2018). Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis. PAIN, 159(11), 2318-2330. https://doi.org/10.1097/j.pain.0000000000001336

In man, central sensitisation (CS) contributes to the pain of osteoarthritis (OA). Dogs with spontaneous OA may also exhibit CS. Electrophysiological reflex measurements are more objective than behavioural assessments, and can be used to evaluate CS... Read More about Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis.

Alfaxalone anaesthesia facilitates electrophysiological recordings of nociceptive withdrawal reflexes in dogs (Canis familiaris) (2016)
Journal Article
Hunt, J., Murrell, J., Knazovicky, D., Harris, J., Kelly, S., Knowles, T. G., & Lascelles, B. D. X. (2016). Alfaxalone anaesthesia facilitates electrophysiological recordings of nociceptive withdrawal reflexes in dogs (Canis familiaris). PLoS ONE, 11(7), 1-18. https://doi.org/10.1371/journal.pone.0158990

Naturally occurring canine osteoarthritis represents a welfare issue for affected dogs (Canis familiaris), but is also considered very similar to human osteoarthritis and has therefore been proposed as a model of disease in humans. Central sensitisat... Read More about Alfaxalone anaesthesia facilitates electrophysiological recordings of nociceptive withdrawal reflexes in dogs (Canis familiaris).

Involvement of spinal ??-adrenoceptors in prolonged modulation of hind limb withdrawal reflexes following acute noxious stimulation in the anaesthetized rabbit (2016)
Journal Article
Harris, J. (2016). Involvement of spinal ??-adrenoceptors in prolonged modulation of hind limb withdrawal reflexes following acute noxious stimulation in the anaesthetized rabbit. European Journal of Neuroscience, 43(6), https://doi.org/10.1111/ejn.13185

The role of spinal α₂-adrenoceptors in mediating long-lasting modulation of hind limb withdrawal reflexes following acute noxious chemical stimulation of distant heterotopic and local homotopic locations has been investigated in pentobarbitone-anaest... Read More about Involvement of spinal ??-adrenoceptors in prolonged modulation of hind limb withdrawal reflexes following acute noxious stimulation in the anaesthetized rabbit.