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All Outputs (113)

Investigating histidinylated highly branched poly(lysine) for siRNA delivery (2021)
Journal Article
Alazzo, A., Gumus, N., Gurnani, P., Stolnik, S., Rahman, R., Spriggs, K., & Alexander, C. (2022). Investigating histidinylated highly branched poly(lysine) for siRNA delivery. Journal of Materials Chemistry B, 10(2), 236-246. https://doi.org/10.1039/d1tb01793d

The temporary silencing of disease-associated genes utilising short interfering RNA (siRNA) is a potent and selective route for addressing a wide range of life limiting disorders. However, the few clinically approved siRNA therapies rely on lipid bas... Read More about Investigating histidinylated highly branched poly(lysine) for siRNA delivery.

Managing medicines at the end of life: a position paper for health policy and practice (2021)
Journal Article
Latif, A., Faull, C., Waring, J., Wilson, E., Anderson, C., Avery, A., & Pollock, K. (2021). Managing medicines at the end of life: a position paper for health policy and practice. Journal of Health Organization and Management, 35(9), 368-377. https://doi.org/10.1108/JHOM-11-2020-0440

Purpose The impact of population aging is significant, multifaceted and characterised by frailty and multi-morbidity. The COVID-19 pandemic has accelerated care pathways and policies promoting self-management and home-based care. One under-researched... Read More about Managing medicines at the end of life: a position paper for health policy and practice.

Managing medicines at the end of life: a position paper for health policy and practice (2021)
Journal Article
Latif, A., Faull, C., Waring, J., Wilson, E., Anderson, C., Avery, A., & Pollock, K. (2021). Managing medicines at the end of life: a position paper for health policy and practice. Journal of Health Organization and Management, 35(9), 368-377. https://doi.org/10.1108/JHOM-11-2020-0440

Purpose: The impact of population ageing is significant, multifaceted and characterised by frailty and multi-morbidity. The COVID-19 pandemic has accelerated care pathways and policies promoting self-management and home-based care. One under-research... Read More about Managing medicines at the end of life: a position paper for health policy and practice.

The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids (2021)
Journal Article
Vijay, A., Kouraki, A., Gohir, S., Turnbull, J., Kelly, A., Chapman, V., …Valdes, A. M. (2021). The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids. Gut Microbes, 13(1), Article 1997559. https://doi.org/10.1080/19490976.2021.1997559

The endocannabinoid (EC) system has pleiotropic functions in the body. It plays a key role in energy homeostasis and the development of metabolic disorders being a mediator in the relationship between the gut microbiota and host metabolism. In the cu... Read More about The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids.

Exploiting the fundamentals of biological organization for the advancement of biofabrication (2021)
Journal Article
Hill, J., Wildman, R., & Mata, A. (2022). Exploiting the fundamentals of biological organization for the advancement of biofabrication. Current Opinion in Biotechnology, 74, 42-54. https://doi.org/10.1016/j.copbio.2021.10.016

The field of biofabrication continues to progress, offering higher levels of spatial control, reproducibility, and functionality. However, we remain far from recapitulating what nature has achieved. Biological systems such as tissues and organs are a... Read More about Exploiting the fundamentals of biological organization for the advancement of biofabrication.

Imaging mass spectrometry of fingermarks on brass bullet casings using sample rotation (2021)
Journal Article
Lee, C. J., Scurr, D. J., Jiang, L., Kenton, A., Beebe, S. R. T., & Sharp, J. S. (2021). Imaging mass spectrometry of fingermarks on brass bullet casings using sample rotation. Analyst, 146(24), 7563-7572. https://doi.org/10.1039/d1an01768c

A rotation stage was developed to allow the surface of bullet casings to be imaged under ultra-high vacuum (UHV) conditions using time-of-flight secondary ion mass spectrometry (ToF-SIMS). Experiments were performed over a period of seven months to d... Read More about Imaging mass spectrometry of fingermarks on brass bullet casings using sample rotation.

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair (2021)
Journal Article
Sanchez-Bailon, M. P., Choi, S. Y., Dufficy, E. R., Sharma, K., McNee, G. S., Gunnell, E., …Davies, C. C. (2021). Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair. Nature Communications, 12(1), Article 6313. https://doi.org/10.1038/s41467-021-26413-6

Cross-talk between distinct protein post-translational modifications is critical for an effective DNA damage response. Arginine methylation plays an important role in maintaining genome stability, but how this modification integrates with other enzym... Read More about Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin (2021)
Journal Article
Tarantini, F. S., Brunati, M., Taravella, A., Carrano, L., Parenti, F., Hong, K. W., …Chan, W. C. (2021). Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin. PLoS ONE, 16(11), Article e0260413. https://doi.org/10.1371/journal.pone.0260413

As part of a screening programme for antibiotic-producing bacteria, a novel Actinomadura species was discovered from a soil sample collected in Santorini, Greece. Preliminary 16S rRNA gene sequence comparisons highlighted Actinomadura macra as the mo... Read More about Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin.

Impedimetric Characterization of Bipolar Nanoelectrodes with Cancer Cells (2021)
Journal Article
Robinson, A. J., Jain, A., Rahman, R., Abayzeed, S., Hague, R. J., & Rawson, F. J. (2021). Impedimetric Characterization of Bipolar Nanoelectrodes with Cancer Cells. ACS Omega, 6(44), 29495-29505. https://doi.org/10.1021/acsomega.1c03547

Merging of electronics with biology, defined as bioelectronics, at the nanoscale holds considerable promise for sensing and modulating cellular behavior. Advancing our understanding of nanobioelectronics will facilitate development and enable applica... Read More about Impedimetric Characterization of Bipolar Nanoelectrodes with Cancer Cells.

The role of clinical pharmacists in general practice in England: Impact, perspectives, barriers and facilitators (2021)
Journal Article
Mann, C., Anderson, C., & Boyd, M. (2022). The role of clinical pharmacists in general practice in England: Impact, perspectives, barriers and facilitators. Research in Social and Administrative Pharmacy, 18(8), 3432-3437. https://doi.org/10.1016/j.sapharm.2021.10.006

Background: By 2020/1 NHS England plans to invest over 100 m to ensure that there is one clinical pharmacist post in primary care for every 30,000 patients. A recent realist review identified key questions in the literature related to the implementat... Read More about The role of clinical pharmacists in general practice in England: Impact, perspectives, barriers and facilitators.

Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms (2021)
Journal Article
Lion, A., Wildman, R. D., Alexander, M. R., & Roberts, C. J. (2021). Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms. Pharmaceutics, 13(10), Article 1679. https://doi.org/10.3390/pharmaceutics13101679

One of the most striking characteristics of 3D printing is its capability to produce multi-material objects with complex geometry. In pharmaceutics this translates to the possibility of dosage forms with multi-drug loading, tailored dosing and releas... Read More about Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms.

Surface-controlled spatially heterogeneous physical properties of a supramolecular gel with homogeneous chemical composition (2021)
Journal Article
Yang, B., Lledos, M., Akhtar, R., Ciccone, G., Jiang, L., Russo, E., …Zelzer, M. (2021). Surface-controlled spatially heterogeneous physical properties of a supramolecular gel with homogeneous chemical composition. Chemical Science, 12(42), 14260-14269. https://doi.org/10.1039/d1sc04671c

Controlling supramolecular self-assembly across multiple length scales to prepare gels with localised properties is challenging. Most strategies concentrate on fabricating gels with heterogeneous components, where localised properties are generated b... Read More about Surface-controlled spatially heterogeneous physical properties of a supramolecular gel with homogeneous chemical composition.

Developing novel anthelmintics : the stability of cysteine proteinase activity in a supernatant extract of papaya latex (2021)
Journal Article
Mansur, F., Luoga, W., Behnke, J., Buttle, D., Duce, I., & Garnett, M. (2021). Developing novel anthelmintics : the stability of cysteine proteinase activity in a supernatant extract of papaya latex. Heliyon, 7(10), 1-6. https://doi.org/10.1016/j.heliyon.2021.e08125

Plant derived cysteine proteinases (CPs) have long been known to possess anthelmintic properties but have attracted renewed attention recently because of the acute need to discover novel methods for controlling helminth infections as a result of incr... Read More about Developing novel anthelmintics : the stability of cysteine proteinase activity in a supernatant extract of papaya latex.

Gastroretentive technologies in tandem with controlled-release strategies: A potent answer to oral drug bioavailability and patient compliance implications (2021)
Journal Article
Vrettos, N. N., Roberts, C. J., & Zhu, Z. (2021). Gastroretentive technologies in tandem with controlled-release strategies: A potent answer to oral drug bioavailability and patient compliance implications. Pharmaceutics, 13(10), 1-36. https://doi.org/10.3390/pharmaceutics13101591

There have been many efforts to improve oral drug bioavailability and therapeutic efficacy and patient compliance. A variety of controlled-release oral delivery systems have been developed to meet these needs. Gastroretentive drug delivery technologi... Read More about Gastroretentive technologies in tandem with controlled-release strategies: A potent answer to oral drug bioavailability and patient compliance implications.

A Systematic Review of the Biological Effects of Cordycepin (2021)
Journal Article
Radhi, M., Ashraf, S., Lawrence, S., Tranholm, A. A., Wellham, P. A. D., Hafeez, A., …De Moor, C. H. (2021). A Systematic Review of the Biological Effects of Cordycepin. Molecules, 26(19), Article 5886. https://doi.org/10.3390/molecules26195886

We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 Fe... Read More about A Systematic Review of the Biological Effects of Cordycepin.

Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology (2021)
Journal Article
Osuna de la Peña, D., Trabulo, S. M. D., Collin, E., Liu, Y., Sharma, S., Tatari, M., …Loessner, D. (2021). Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology. Nature Communications, 12, Article 5623. https://doi.org/10.1038/s41467-021-25921-9

Patient-derived in vivo models of human cancer have become a reality, yet their turnaround time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully recapitulate in vivo tumour biology are urgently needed. These... Read More about Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology.

Polymyxin B‐Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy (2021)
Journal Article
Shi, Y., Wareham, D. W., Yuan, Y., Deng, X., Mata, A., & Azevedo, H. S. (2021). Polymyxin B‐Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy. Advanced Healthcare Materials, 10(22), Article 2101465. https://doi.org/10.1002/adhm.202101465

Repurposing old antibiotics into more effective and safer formulations is an emergent approach to tackle the growing threat of antimicrobial resistance. Herein, a peptide hydrogel is reported for the localized and sustained release of polymyxin B (PM... Read More about Polymyxin B‐Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy.

Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal (2021)
Journal Article
El-Melegy, M. G., Eltaher, H. M., Gaballah, A., & El-Kamel, A. H. (2021). Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal. European Journal of Pharmaceutics and Biopharmaceutics, 168, 166-183. https://doi.org/10.1016/j.ejpb.2021.08.020

Hepatocellular carcinoma (HCC) is a prevalent liver cancer representing the fourth most lethal cancer worldwide. Trans-Resveratrol (T-R) possesses a promising anticancer activity against HCC. However, it suffers from poor bioavailability because of t... Read More about Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal.