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Exploiting the fundamentals of biological organization for the advancement of biofabrication

Hill, Jordan; Wildman, Ricky; Mata, Alvaro

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Authors

Jordan Hill

RICKY WILDMAN RICKY.WILDMAN@NOTTINGHAM.AC.UK
Professor of Multiphase Flow and Mechanics



Abstract

The field of biofabrication continues to progress, offering higher levels of spatial control, reproducibility, and functionality. However, we remain far from recapitulating what nature has achieved. Biological systems such as tissues and organs are assembled from the bottom-up through coordinated supramolecular and cellular processes that result in their remarkable structures and functionalities. In this perspective, we propose that incorporating such biological assembling mechanisms within fabrication techniques, offers an opportunity to push the boundaries of biofabrication. We dissect these mechanisms into distinct biological organization principles (BOPs) including self-assembly, compartmentalization, diffusion-reaction, disorder-to-order transitions, and out-of-equilibrium processes. We highlight recent work demonstrating the viability and potential of these approaches to enhance scalability, reproducibility, vascularization, and biomimicry; as well as current challenges to overcome.

Citation

Hill, J., Wildman, R., & Mata, A. (2022). Exploiting the fundamentals of biological organization for the advancement of biofabrication. Current Opinion in Biotechnology, 74, 42-54. https://doi.org/10.1016/j.copbio.2021.10.016

Journal Article Type Article
Acceptance Date Oct 14, 2021
Online Publication Date Nov 17, 2021
Publication Date Apr 1, 2022
Deposit Date Jan 12, 2022
Publicly Available Date Nov 18, 2022
Journal Current Opinion in Biotechnology
Print ISSN 0958-1669
Electronic ISSN 1879-0429
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 74
Pages 42-54
DOI https://doi.org/10.1016/j.copbio.2021.10.016
Keywords Biomedical Engineering; Bioengineering; Biotechnology
Public URL https://nottingham-repository.worktribe.com/output/7225470
Publisher URL https://www.sciencedirect.com/science/article/pii/S0958166921002032?via%3Dihub

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