All Outputs (88)

The antimalarial drug quinine interferes with serotonin biosynthesis and action (2014)
Journal Article

The major antimalarial drug quinine perturbs uptake of the essential amino acid tryptophan, and patients with low plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indications of tryptophan depletion. As... Read More about The antimalarial drug quinine interferes with serotonin biosynthesis and action.

The direct medical costs of epilepsy in children and young people: a population-based study of health resource utilisation (2014)
Journal Article

We described the health resource utilisation (HRU) and associated direct medical costs of managing epilepsy in children and young people (CYP) using population-level data from the United Kingdom. The study cohort were CYP born between 1988 and 20... Read More about The direct medical costs of epilepsy in children and young people: a population-based study of health resource utilisation.

A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells (2014)
Journal Article

Recently, it has been reported that anti-viral drugs, such as indinavir and lopinavir (originally targeted for HIV), also inhibit E6-mediated proteasomal degradation of mutant p53 in E6-transfected C33A cells. In order to understand more about the mo... Read More about A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells.

Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73 (2014)
Journal Article

Dysregulation of cellular transcription and translation is a fundamental hallmark of cancer. As CDK9 and Mnks play pivotal roles in the regulation of RNA transcription and protein synthesis, respectively, they are important targets for drug developme... Read More about Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73.

Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres (2014)
Journal Article

Three-dimensional cell culture has many advantages over monolayer cultures, and spheroids have been hailed as the best current representation of small avascular tumours in vitro. However their adoption in regular screening programs has been hindered... Read More about Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres.

The double PHD finger domain of MOZ/MYST3 induces ?-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification (2014)
Journal Article

Histone tail modifications control many nuclear processes by dictating the dynamic exchange of regulatory proteins on chromatin. Here we report novel insights into histone H3 tail structure in complex with the double PHD finger (DPF) of the lysine ac... Read More about The double PHD finger domain of MOZ/MYST3 induces ?-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.

Interface and surface analysis for pharmaceutical applications: challenges and recent advances (2014)
Journal Article

Innovation in R&D is a key target for the pharmaceutical sector to address some of the challenges it currently faces. This review discusses these challenges in the context of pharmaceutically relevant surfaces and interfaces. The surface properties o... Read More about Interface and surface analysis for pharmaceutical applications: challenges and recent advances.

Reductions in Endocannabinoid Levels and Enhanced Coupling of Cannabinoid Receptors in the Striatum are Accompanied by Cognitive Impairments in the A?PPswe/PS1?E9 Mouse Model of Alzheimer's Disease (2014)
Journal Article

© 2014 - IOS Press and the authors. All rights reserved. Alterations in the endocannabinoid system (ECS) are thought to play a role in learning and memory impairments observed in Alzheimer's disease (AD). We aimed to determine the status of the brain... Read More about Reductions in Endocannabinoid Levels and Enhanced Coupling of Cannabinoid Receptors in the Striatum are Accompanied by Cognitive Impairments in the A?PPswe/PS1?E9 Mouse Model of Alzheimer's Disease.