All Outputs (103)

New Found Hope for Antibiotic Discovery: Lipid II Inhibitors (2016)
Journal Article
Ng, V., & Chan, W. C. (2016). New Found Hope for Antibiotic Discovery: Lipid II Inhibitors. Chemistry - A European Journal, 22(36), 12606-12616. https://doi.org/10.1002/chem.201601315

Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of antimicrobial resistance. The development of modern tools offers the opportunity of reviving the fallen era of antibacterial discovery through uncoveri... Read More about New Found Hope for Antibiotic Discovery: Lipid II Inhibitors.

Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly (2016)
Journal Article
Adler-Abramovich, L., Marco, P., Arnon, Z. A., Creasey, R. C., Michaels, T. C., Levin, A., …Gazit, E. (2016). Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly. ACS Nano, 10(8), 7436-7442. https://doi.org/10.1021/acsnano.6b01587

Molecular self-assembly of peptides into ordered nanotubes is highly important for various technological applications. Very short peptide building blocks, as short as dipeptides, can form assemblies with unique mechanical, optical, piezoelectric, and... Read More about Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly.

Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency (2016)
Journal Article
Capel, V., Vllasaliu, D., Watts, P., & Stolnik, S. (2016). Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency. Biochemical and Biophysical Research Communications, 477(2), 260-265. https://doi.org/10.1016/j.bbrc.2016.06.054

Despite research efforts, cell uptake processes determining siRNA silencing efficiency remain unclear. Here, we examine the relationship between in vitro cell culture models, cellular trafficking and siRNA silencing efficiency to provide a mechanisti... Read More about Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency.

Dynamic surfaces for the study Of mesenchymal stem cell growth through adhesion regulation (2016)
Journal Article
Roberts, J., Sahoo, J., McNamara, L., Burgess, K., Yang, J., Alakpa, E., …Dalby, M. (2016). Dynamic surfaces for the study Of mesenchymal stem cell growth through adhesion regulation. ACS Nano, 10(7), 6667-6679. https://doi.org/10.1021/acsnano.6b01765

Out of their niche environment, adult stem cells, such as mesenchymal stem cells (MSCs), spontaneously differentiate. This makes both studying these important regenerative cells and growing large numbers of stem cells for clinical use challenging. Tr... Read More about Dynamic surfaces for the study Of mesenchymal stem cell growth through adhesion regulation.

Salt Effects on the Thermodynamics of a Frameshifting RNA Pseudoknot under Tension (2016)
Journal Article
Hori, N., Denesyuk, N. A., & Thirumalai, D. (2016). Salt Effects on the Thermodynamics of a Frameshifting RNA Pseudoknot under Tension. Journal of Molecular Biology, 428(14), 2847-2859. https://doi.org/10.1016/j.jmb.2016.06.002

Because of the potential link between − 1 programmed ribosomal frameshifting and response of a pseudoknot (PK) RNA to force, a number of single-molecule pulling experiments have been performed on PKs to decipher the mechanism of programmed ribosomal... Read More about Salt Effects on the Thermodynamics of a Frameshifting RNA Pseudoknot under Tension.

Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate (2016)
Journal Article
Eltaher, H. M., Yang, J., Shakesheff, K. M., & Dixon, J. E. (2016). Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate. Acta Biomaterialia, 41, 181-192. https://doi.org/10.1016/j.actbio.2016.06.004

Fundamental behaviour such as cell fate, growth and death are mediated through the control of key genetic transcriptional regulators. These regulators are activated or repressed by the integration of multiple signalling molecules in spatio-temporal g... Read More about Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate.

Proposing the use of partial AUC as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics (2016)
Journal Article
Lee, L. H. N., Choi, C., Gershkovich, P., Barr, A. M., Honer, W. G., & Procyshyn, R. M. (2016). Proposing the use of partial AUC as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics. European Journal of Drug Metabolism and Pharmacokinetics, 41(6), 659-664. https://doi.org/10.1007/s13318-016-0348-z

The maximum plasma concentration (Cmax) and the area under the plasma concentration–time curve (AUC) are commonly used to establish bioequivalence between two formulations of the same oral medication. Similarly, these pharmacokinetic parameters have... Read More about Proposing the use of partial AUC as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics.

Hydromorphone for neuropathic pain in adults (2016)
Journal Article
Stannard, C., Gaskell, H., Derry, S., Aldington, D., Cole, P., Cooper, T. E., …Moore, R. A. (2016). Hydromorphone for neuropathic pain in adults. Cochrane Database of Systematic Reviews, Article CD011604. https://doi.org/10.1002/14651858.CD011604.pub2

BACKGROUND Opioid drugs, including hydromorphone, are commonly used to treat neuropathic pain, and are considered effective by some professionals. Most reviews have examined all opioids together. This review sought evidence specifically for hydrom... Read More about Hydromorphone for neuropathic pain in adults.

Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation (2016)
Journal Article
Gschwandtner, M., Piccinini, A. M., Geriza, T., Adage, T., & Kungl, A. (2016). Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation. Neuroscience Letters, 626, 164-173. https://doi.org/10.1016/j.neulet.2016.05.037

© 2016 Elsevier Ireland Ltd. Multiple Sclerosis, a chronic inflammatory demyelinating disease of the central nervous system, involves an increased expression of monocyte chemotactic protein 1 MCP1-/CCL2. For exerting its chemotactic effects, chemokin... Read More about Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation.

Describing the characteristics, treatment pathways, outcomes, and costs of people with persistent noncancer pain managed by community pain clinics and generating an indicative estimate of cost-effectiveness: feasibility study protocol (2016)
Journal Article
AlAujan, S., AlMazrou, S., Knaggs, R. D., & Elliott, R. A. (2016). Describing the characteristics, treatment pathways, outcomes, and costs of people with persistent noncancer pain managed by community pain clinics and generating an indicative estimate of cost-effectiveness: feasibility study protocol. Journal of Multidisciplinary Healthcare, 9, https://doi.org/10.2147/JMDH.S97904

BACKGROUND Low back pain (LBP) and fibromyalgia (FM), also known as chronic widespread pain (CWP), are highly prevalent chronic painful conditions that have substantial impact on patients, health care systems, and society. Diagnosis is complex and... Read More about Describing the characteristics, treatment pathways, outcomes, and costs of people with persistent noncancer pain managed by community pain clinics and generating an indicative estimate of cost-effectiveness: feasibility study protocol.

The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment (2016)
Journal Article
Ya?ayan, G., Xue, X., Collier, P., Clarke, P., Alexander, M. R., & Marlow, M. (2016). The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment. Nanotechnology, 27(25), https://doi.org/10.1088/0957-4484/27/25/255102

In this study, we have produced nanotextured poly(lactic-co-glycolic acid) (PLGA) films by using polystyrene (PS) particles as a template to make a polydimethylsiloxane mould against which PLGA is solvent cast. Biocompatible, biodegradable and nanote... Read More about The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment.

Surface chemistry of Ti6Al4V components fabricated using selective laser melting for biomedical applications (2016)
Journal Article
Vaithilingam, J., Prina, E., Goodridge, R. D., Hague, R. J., Edmondson, S., Rose, F. R., & Christie, S. D. (2016). Surface chemistry of Ti6Al4V components fabricated using selective laser melting for biomedical applications. Materials Science and Engineering: C, 67, 294-303. https://doi.org/10.1016/j.msec.2016.05.054

Selective laser melting (SLM) has previously been shown to be a viable method for fabricating biomedical implants; however, the surface chemistry of SLM fabricated parts is poorly understood. In this study, X-ray photoelectron spectroscopy (XPS) was... Read More about Surface chemistry of Ti6Al4V components fabricated using selective laser melting for biomedical applications.

Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability (2016)
Journal Article
Leire, E., Amaral, S. P., Louzao, I., Winzer, K., Alexander, C., Fernandez-Megia, E., & Fernandez-Trillo, F. (2016). Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability. Biomaterials Science, 4(6), https://doi.org/10.1039/C6BM00079G

Here, we evaluate how cationic gallic acid-triethylene glycol (GATG) dendrimers interact with bacteria and their potential to develop new antimicrobials. We demonstrate that GATG dendrimers functionalised with primary amines in their periphery can in... Read More about Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability.

Identification of patients with atrial fibrillation in UK community pharmacy: an evaluation of a new service (2016)
Journal Article
Twigg, M. J., Thornley, T., & Scobie, N. (2016). Identification of patients with atrial fibrillation in UK community pharmacy: an evaluation of a new service. International Journal of Clinical Pharmacy, 38(4), 784-787. https://doi.org/10.1007/s11096-016-0303-8

Background Many patients with atrial fibrillation (AF) are asymptomatic and diagnosed via opportunistic screening. Community pharmacy has been advocated as a potential resource for opportunistic screening and lifestyle interventions. Objective The ob... Read More about Identification of patients with atrial fibrillation in UK community pharmacy: an evaluation of a new service.

The composite influence of the imidazolone moiety of CGP 12177 on its affinity and efficacy at the two conformations of the human ?1-adrenoceptor (2016)
Conference Proceeding
Mistry, S. N., & Baker, J. G. (2016). The composite influence of the imidazolone moiety of CGP 12177 on its affinity and efficacy at the two conformations of the human ?1-adrenoceptor.

The effect of the N-alkyl moiety on the interaction of pindolol analogues with the two agonist conformations of the human ?1-adrenoceptor (2016)
Conference Proceeding
Mistry, S. N., & Baker, J. G. (2016). The effect of the N-alkyl moiety on the interaction of pindolol analogues with the two agonist conformations of the human ?1-adrenoceptor.

Influence of polymer size on uptake and cytotoxicity of doxorubicin-loaded DNA–PEG conjugates (2016)
Journal Article
Purdie, L., Alexander, C., Spain, S. G., & Magnusson, J. P. (2016). Influence of polymer size on uptake and cytotoxicity of doxorubicin-loaded DNA–PEG conjugates. Bioconjugate Chemistry, 27(5), https://doi.org/10.1021/acs.bioconjchem.6b00085

Intercalation of drugs into assembled DNA systems offers versatile new mechanisms for controlled drug delivery. However, current systems are becoming increasingly complex, reducing the practicality of large scale production. Here, we demonstrate a mo... Read More about Influence of polymer size on uptake and cytotoxicity of doxorubicin-loaded DNA–PEG conjugates.

Polysilicon-chromium-gold intracellular chips for multi-functional biomedical applications (2016)
Journal Article
Patiño, T., Soriano, J., Amirthalingam, E., Duran, S., González-Campo, A., Duch, M., …Nogués, C. (2016). Polysilicon-chromium-gold intracellular chips for multi-functional biomedical applications. Nanoscale, 8(16), https://doi.org/10.1039/c5nr09022a

The development of micro- and nanosystems for their use in biomedicine is a continuously growing field. One of the major goals of such platforms is to combine multiple functions in a single entity. However, achieving the design of an efficient and sa... Read More about Polysilicon-chromium-gold intracellular chips for multi-functional biomedical applications.

Quadruple labelled dual oxygen and pH-sensitive ratiometric nanosensors (2016)
Journal Article
Chauhan, V. M., Giuntini, F., & Aylott, J. W. (2016). Quadruple labelled dual oxygen and pH-sensitive ratiometric nanosensors. Sensing and Bio-Sensing Research, 8, https://doi.org/10.1016/j.sbsr.2016.03.007

Nanosensors capable of simultaneously measuring dissolved oxygen concentrations from 0 to 100% saturation and pH over the full physiological range, from pH 3.5 to 7.5, that advance the methods towards understanding of key biological gradients, were s... Read More about Quadruple labelled dual oxygen and pH-sensitive ratiometric nanosensors.

The role of acid-base imbalance in statin-induced myotoxicity (2016)
Journal Article
Taha, D. A., de Moor, C. H., Barrett, D. A., Lee, J. B., Gandhi, R. D., Hoo, C. W., & Gershkovich, P. (2016). The role of acid-base imbalance in statin-induced myotoxicity. Translational Research, The Journal of Laboratory and Clinical Medicine, 174, 140-160.e14. https://doi.org/10.1016/j.trsl.2016.03.015

Disturbances in acid-base balance, such as acidosis and alkalosis, have potential to alter the pharmacological and toxicological outcomes of statin therapy. Statins are commonly prescribed for elderly patients who have multiple co-morbidities such as... Read More about The role of acid-base imbalance in statin-induced myotoxicity.