Skip to main content

Research Repository

Advanced Search

All Outputs (1558)

The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk (2023)
Journal Article

Background and Purpose Drug-induced reduction of the rapid delayed rectifier potassium current carried by the human Ether-à-go-go-Related Gene (hERG) channel is associated with increased risk of arrhythmias. Recent updates to drug safety regulatory... Read More about The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk.

Elementary effects for models with dimensional inputs of arbitrary type and range: Scaling and trajectory generation (2023)
Journal Article

The Elementary Effects method is a global sensitivity analysis approach for identifying (un)important parameters in a model. However, it has almost exclusively been used where inputs are dimensionless and take values on [0, 1]. Here, we consider mode... Read More about Elementary effects for models with dimensional inputs of arbitrary type and range: Scaling and trajectory generation.

Deep Learning of Transition Probability Densities for Stochastic Asset Models with Applications in Option Pricing (2023)
Journal Article

Transition probability density functions (TPDFs) are fundamental to computational finance, including option pricing and hedging. Advancing recent work in deep learning, we develop novel neural TPDF generators through solving backward Kolmogorov equat... Read More about Deep Learning of Transition Probability Densities for Stochastic Asset Models with Applications in Option Pricing.

The non-local Lotka-Volterra system with a top hat kernel - Part 1: dynamics and steady states with small diffusivity (2023)
Journal Article

We study the dynamics of the non-local Lotka-Volterra system ut=Duuxx+u(1-φ - u-αv), vt=Dvvxx+v(1-φ - v-βu), where a star denotes the spatial convolution and the kernel φ is a top hat function. We initially focus on the case of small, equal diffusivi... Read More about The non-local Lotka-Volterra system with a top hat kernel - Part 1: dynamics and steady states with small diffusivity.

Multiscale asymptotic analysis reveals how cell growth and subcellular compartments affect tissue-scale hormone transport (2023)
Journal Article

Determining how cell-scale processes lead to tissue-scale patterns is key to understanding how hormones and morphogens are distributed within biological tissues and control developmental processes. In this article, we use multiscale asymptotic analys... Read More about Multiscale asymptotic analysis reveals how cell growth and subcellular compartments affect tissue-scale hormone transport.