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Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models? (2015)
Journal Article

Cardiac electrophysiology models have been developed for over 50 years, and now include detailed descriptions of individual ion currents and sub-cellular calcium handling. It is commonly accepted that there are many uncertainties in these systems, wi... Read More about Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?.

Compensated convexity, multiscale medial axis maps and sharp regularity of the squared-distance function (2015)
Journal Article

In this paper we introduce a new stable mathematical model for locating and measuring the medial axis of geometric objects, called the quadratic multiscale medial axis map of scale λ, and provide a sharp regularity result for the squared-distance fun... Read More about Compensated convexity, multiscale medial axis maps and sharp regularity of the squared-distance function.

Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential (2015)
Journal Article

© 2015 Heart Rhythm Society. Background Bradycardic agents are of interest for the treatment of ischemic heart disease and heart failure, as heart rate is an important determinant of myocardial oxygen consumption. Objectives The purpose of this study... Read More about Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.