Skip to main content

Research Repository

Advanced Search

All Outputs (1731)

Equine influenza: A review of an unpredictable virus (2010)
Journal Article
Daly, J. M., MacRae, S., Richard Newton, J., Wattrang, E., & Elton, D. M. (2011). Equine influenza: A review of an unpredictable virus. Veterinary Journal, 189(1), 7-14. https://doi.org/10.1016/j.tvjl.2010.06.026

This review discusses some of the challenges still faced in the control of equine influenza virus H3N8 infection. A widespread outbreak of equine influenza in the United Kingdom during 2003 in vaccinated Thoroughbred racehorses challenged the current... Read More about Equine influenza: A review of an unpredictable virus.

Intra- and interhost evolutionary dynamics of equine influenza virus (2010)
Journal Article
Murcia, P. R., Baillie, G. J., Daly, J., Elton, D., Carley Jervis, Mumford, J. A., Newton, R., Parrish, C. R., Hoelzer, K., Dougan, G., Parkhill, J., Lennard, N., Ormond, D., Moule, S., Whitwham, A., McCauley, J. W., McKinley, T. J., Holmes, E. C., Grenfell, B. T., & Wood, J. L. (2010). Intra- and interhost evolutionary dynamics of equine influenza virus. Journal of Virology, 84(14), https://doi.org/10.1128/JVI.00112-10

Determining the evolutionary basis of cross-species transmission and immune evasion is key to understanding the mechanisms that control the emergence of either new viruses or novel antigenic variants with pandemic potential. The hemagglutinin glycopr... Read More about Intra- and interhost evolutionary dynamics of equine influenza virus.

Effect of delivery method on the efficacy of Salmonella vaccination in chickens (2010)
Journal Article
Atterbury, R. J., Morris, V., Harrison, D., Tucker, V., Allen, V., Davies, R., & Carrique-Mas, J. (2010). Effect of delivery method on the efficacy of Salmonella vaccination in chickens. Veterinary Record, 167(5), https://doi.org/10.1136/vr.b4884

To investigate whether the efficacy of live vaccines is influenced by the mode of vaccine delivery, a widely-used UK live commercial Salmonella Enteritidis vaccine was delivered to pullet chicks either by spray, in drinking water, or in combination w... Read More about Effect of delivery method on the efficacy of Salmonella vaccination in chickens.

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing (2010)
Journal Article
James, V., Zhang, Y., Foxler, D. E., de Moor, C. H., Kong, Y. W., Webb, T. M., Self, T. J., Feng, Y., Lagos, D., Chu, C.-Y., Rana, T. M., Morley, S. J., Longmore, G. D., Bushell, M., & Sharp, T. V. (2010). LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proceedings of the National Academy of Sciences, 107(28), 12499-12504. https://doi.org/10.1073/pnas.0914987107

In recent years there have been major advances with respect to the identification of the protein components and mechanisms of microRNA (miRNA) mediated silencing. However, the complete and precise repertoire of components and mechanism(s) of action r... Read More about LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability (2010)
Journal Article
Carter, S. D., Dent, K. C., Atkins, E., Foster, T. L., Verow, M., Gorny, P., Harris, M., Hiscox, J. A., Ranson, N. A., Griffin, S., & Barr, J. N. (2010). Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability. FEBS Letters, 584(13), 2786-2790. https://doi.org/10.1016/j.febslet.2010.05.006

Human respiratory syncytial virus (HRSV) is the leading cause of lower respiratory tract disease in infants. The HRSV small hydrophobic (SH) protein plays an important role in HRSV pathogenesis, although its mode of action is unclear. Analysis of the... Read More about Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability.

Evaluation of two commercially available ELISAs for the diagnosis of Japanese encephalitis applied to field samples (2010)
Journal Article
Lewthwaite, P., Shankar, M. V., Tio, P.-H., Daly, J., Last, A., Ravikumar, R., Desai, A., Ravi, V., Cardosa, J. M., & Solomon, T. (2010). Evaluation of two commercially available ELISAs for the diagnosis of Japanese encephalitis applied to field samples. Tropical Medicine and International Health, 15(7), 811-818. https://doi.org/10.1111/j.1365-3156.2010.02537.x

Objective To compare two commercially available kits, Japanese Encephalitis-Dengue IgM Combo ELISA (Panbio Diagnostics) and JEV-CheX IgM capture ELISA (XCyton Diagnostics Limited), to a reference standard (Universiti Malaysia Sarawak – Venture Techno... Read More about Evaluation of two commercially available ELISAs for the diagnosis of Japanese encephalitis applied to field samples.

Structure and dynamics of double helical DNA in torsion angle hyperspace: a molecular mechanics approach. (2010)
Journal Article
Borkar, A., Ghosh, I., & Bhattacharyya, D. (2010). Structure and dynamics of double helical DNA in torsion angle hyperspace: a molecular mechanics approach. Journal of Biomolecular Structure and Dynamics, 27(5), 695-712. https://doi.org/10.1080/07391102.2010.10508582

Analysis of the conformational space populated by the torsion angles and the correlation between the conformational energy and the sequence of DNA are important for fully under-standing DNA structure and function. Presence of seven variable torsion a... Read More about Structure and dynamics of double helical DNA in torsion angle hyperspace: a molecular mechanics approach..

Dynamics of influenza virus infection and pathology (2010)
Journal Article
Saenz, R. A., Quinlivan, M., Elton, D., MacRae, S., Blunden, A. S., Mumford, J. A., Daly, J. M., Digard, P., Cullinane, A., Grenfell, B. T., McCauley, J. W., Wood, J. L., & Gog, J. R. (2010). Dynamics of influenza virus infection and pathology. Journal of Virology, 84(8), https://doi.org/10.1128/JVI.02078-09

A key question in pandemic influenza is the relative roles of innate immunity and target cell depletion in limiting primary infection and modulating pathology. Here, we model these interactions using detailed data from equine influenza virus infectio... Read More about Dynamics of influenza virus infection and pathology.

Bacterial cell surface display: A method for studying Japanese encephalitis virus pathogenicity (2009)
Journal Article
Dou, J., Daly, J., Yuan, Z., Jing, T., & Solomon, T. (2009). Bacterial cell surface display: A method for studying Japanese encephalitis virus pathogenicity. Japanese Journal of Infectious Diseases, 62(5), 402-408

Infection with Japanese encephalitis virus (JEV), a mosquito-borne, neurotropic flavivirus, may cause acute encephalitis in humans. Recombinant Salmonella typhimurium BRD509 was constructed to display domain III of the envelope (E) protein of JEV (JE... Read More about Bacterial cell surface display: A method for studying Japanese encephalitis virus pathogenicity.

Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif (2009)
Journal Article
Egan, S. A., Kurian, D., Ward, P. N., Hunt, L., & Leigh, J. A. (2009). Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif. Journal of Proteome Research, 9(2), https://doi.org/10.1021/pr901025w

Sortase (a transamidase) has been shown to be responsible for the covalent attachment of proteins to the bacterial cell wall. Anchoring is effected on secreted proteins containing a specific cell wall motif toward their C-terminus; that for sortase A... Read More about Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif.

Developmental origins of obesity: Programming of food intake or physical activity? (2009)
Presentation / Conference Contribution
Gardner, D. S., & Rhodes, P. (2008, August). Developmental origins of obesity: Programming of food intake or physical activity?. Presented at Advances Exp Biol and Med, Ghent

Mans ability to capture, harness and store energy most efficiently as fat in adipose tissue has been an evolutionary success story for the majority of human existence. Only over the last 30-40 years has our remarkable metabolic efficiency been reveal... Read More about Developmental origins of obesity: Programming of food intake or physical activity?.

Quantifying the impact of immune escape on transmission dynamics of influenza (2009)
Journal Article
Park, A. W., Daly, J. M., Lewis, N. S., Smith, D. J., Wood, J. L., & Grenfell, B. T. (2009). Quantifying the impact of immune escape on transmission dynamics of influenza. Science, 326(5953), 726-728. https://doi.org/10.1126/science.1175980

Influenza virus evades prevailing natural and vaccine-induced immunity by accumulating antigenic change in the haemagglutinin surface protein. Linking amino acid substitutions in haemagglutinin epitopes to epidemiology has been problematic because of... Read More about Quantifying the impact of immune escape on transmission dynamics of influenza.

Salmonella colonisation of laying hens following vaccination with killed and live attenuated commercial Salmonella vaccines (2009)
Journal Article
Atterbury, R. J., Carrique-Mas, J. J., Davies, R. H., & Allen, V. M. (2009). Salmonella colonisation of laying hens following vaccination with killed and live attenuated commercial Salmonella vaccines. Veterinary Record, 165(17), 493-496. https://doi.org/10.1136/vr.165.17.493

The aim of this study was to determine the efficacy of a killed Salmonella vaccine and three live vaccines in preventing caecal colonisation of Hy-line Brown pullets by Salmonella Enteritidis PT 4. The lowest number of Salmonello-positive birds follo... Read More about Salmonella colonisation of laying hens following vaccination with killed and live attenuated commercial Salmonella vaccines.

Bacteriophage biocontrol in animals and meat products (2009)
Journal Article
Atterbury, R. (2009). Bacteriophage biocontrol in animals and meat products. Microbial Biotechnology, 2(6), 601-612. https://doi.org/10.1111/j.1751-7915.2009.00089.x

Since their discovery almost a century ago, bacterial viruses (bacteriophages or 'phages') have been used to prevent and treat a multitude of bacterial infections (phage therapy: PT). In addition, they have been the basis for many advances in genetic... Read More about Bacteriophage biocontrol in animals and meat products.

Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation (2009)
Journal Article
Rhodes, P., Craigon, J., Gray, C., Rhind, S. M., Loughna, P. T., & Gardner, D. S. (2009). Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PLoS ONE, 4(10), Article e7393. https://doi.org/10.1371/journal.pone.0007393

Background:
Obesity invokes a range of metabolic disturbances, but the transition from a poor to excessive nutritional environment may exacerbate adult metabolic dysfunction. The current study investigated global maternal nutrient restriction durin... Read More about Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation.

Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring (2009)
Journal Article
Sharkey, D., Gardner, D. S., Symonds, M. E., & Budge, H. (2009). Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring. AJP - Renal Physiology, 297(5), F1199-F1207. https://doi.org/10.1152/ajprenal.00303.2009

Obesity is an independent risk factor for developing chronic kidney disease. Toll-like receptor 4 (TLR4), interleukin (IL)-18, and uncoupling protein 2 (UCP2) are important components of the innate immune system mediating inflammatory renal damage. E... Read More about Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring.

Maternal administration of anti-angiogenic agents, TNP-470 and angiostatin₄.₅, induces fetal microphthalmia (2009)
Journal Article
Rutland, C. S., Jiang, K., Soff, G. A., & Mitchell, C. A. (2009). Maternal administration of anti-angiogenic agents, TNP-470 and angiostatin₄.₅, induces fetal microphthalmia. Molecular Vision, 15, 1260-1269

Purpose: Agents specifically targeting the vasculature as a mode of therapy are finding increasing use in the clinic, primarily in the treatment of colon cancer (Avastin™) and age-related macular degeneration (Lucentis™). We have previously shown tha... Read More about Maternal administration of anti-angiogenic agents, TNP-470 and angiostatin₄.₅, induces fetal microphthalmia.

Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis (2009)
Journal Article
Rutland, C., Warner, L., Thorpe, A., Alibhai, A., Robinson, T., Shaw, B., Layfield, R., Brook, D. J., & Loughna, S. (2009). Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis. Journal of Anatomy, 214(6), 905-915. https://doi.org/10.1111/j.1469-7580.2009.01079.x

Atrial septal defects are a common congenital heart defect in humans. Although mutations in different genes are now frequently being described, little is known about the processes and mechanisms behind the early stages of atrial septal development. B... Read More about Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis.