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The effect of oral feeding on gastrointestinal function, motility and appetite-regulating hormones, insulin, glucose and satiety in normal weight individuals and those with obesity (2025)
Journal Article
Simpson, E. J., Althubeati, S., Cordon, S., Hoad, C., Bush, D., Eldeghaidy, S., Gowland, P. A., Macdonald, I. A., & Lobo, D. N. (2025). The effect of oral feeding on gastrointestinal function, motility and appetite-regulating hormones, insulin, glucose and satiety in normal weight individuals and those with obesity. Clinical Nutrition, 52, 62-71. https://doi.org/10.1016/j.clnu.2025.07.008

Background and aims
The primary aim of this study was to evaluate the effect of ingestion of a standardized meal on gastric content volume and gastric emptying time in healthy normal weight people and those with obesity. Secondary aims were to evalu... Read More about The effect of oral feeding on gastrointestinal function, motility and appetite-regulating hormones, insulin, glucose and satiety in normal weight individuals and those with obesity.

Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies (2025)
Journal Article
Long, T., Milbourn, C. C., Smith, A., Linn Su Khin, K., Page, A. J., Idris, I., Yang, Q., Young, R. L., & Eldeghaidy, S. (2025). Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies. Life, 15(7), Article 1075. https://doi.org/10.3390/life15071075

Sweet sensing is a fundamental sensory experience that plays a critical role not only in food preference, reward and dietary behaviour but also in glucose metabolism. Sweet taste receptors (STRs), composed of a heterodimer of taste receptor type 1 me... Read More about Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies.

Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index (2025)
Journal Article
Ivell, R., Tilumcu, B., Alhujaili, W., & Anand‐Ivell, R. (2025). Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index. Andrology, https://doi.org/10.1111/andr.70091

Background: The constitutive Leydig cell hormone insulin-like peptide 3 (INSL3) is considered a good estimate of the adult Leydig cell functional capacity and appears to remain relatively consistent throughout adult male life, only gradually declinin... Read More about Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index.

Characterisation of dynamic changes in nutritional components and aroma compound formation in natto during fermentation and post-ripening (2025)
Journal Article
Sun, M., Yang, N., He, Y., Miao, X., Niu, H., Hua, M., Wang, J., & Li, D. (2025). Characterisation of dynamic changes in nutritional components and aroma compound formation in natto during fermentation and post-ripening. Food Research International, 219, Article 116961. https://doi.org/10.1016/j.foodres.2025.116961

Fermentation and post-ripening plays a significant role in shaping the nutritional value, taste, and aroma of natto. This study aimed to analyse nutritional trends in natto during fermentation and ripening, identify its characteristic volatile organi... Read More about Characterisation of dynamic changes in nutritional components and aroma compound formation in natto during fermentation and post-ripening.

Treatment of fruit juices with β-glucosidase for release of aroma precursors (2025)
Journal Article
Schmidt, S., Yang, N., Gröger, H., Saarela, M., Hessel, V., & Fisk, I. (2025). Treatment of fruit juices with β-glucosidase for release of aroma precursors. Food Chemistry, 491, Article 145212. https://doi.org/10.1016/j.foodchem.2025.145212

Β-glucosidase can diversify flavour by releasing aroma precursors from monosaccharide glucosides but is not yet applied in fruit juice processing. Here, we compare β-glucosidase A (BglA) from the extremophile Halothermothrix orenii H168 expressed in... Read More about Treatment of fruit juices with β-glucosidase for release of aroma precursors.

Effects of replacing protein with non-protein nitrogen sources on growth, development and composition of Tenebrio molitor larvae (2025)
Journal Article
Tamim, B., Parr, T., Brameld, J., & Salter, A. (2025). Effects of replacing protein with non-protein nitrogen sources on growth, development and composition of Tenebrio molitor larvae. Journal of Insects as Food and Feed, 1-10. https://doi.org/10.1163/23524588-bja10241

It is suggested that Tenebrio molitor larvae (yellow mealworms) have the capacity to fix non-protein nitrogen (NPN) to produce amino acids. To test this, mealworms were fed an alpha-cellulose-based synthetic feed (Cell+) containing sources of energy... Read More about Effects of replacing protein with non-protein nitrogen sources on growth, development and composition of Tenebrio molitor larvae.

Detection of aphid infestation on faba bean (Vicia faba L.) by hyperspectral imaging and spectral information divergence methods (2025)
Journal Article
Saeidan, A., Caulfield, J., Vuts, J., Yang, N., & Fisk, I. (2025). Detection of aphid infestation on faba bean (Vicia faba L.) by hyperspectral imaging and spectral information divergence methods. Journal of Plant Diseases and Protection, 132, Article 109. https://doi.org/10.1007/s41348-025-01100-6

Aphids hide under leaves, reproduce rapidly, and require early detection to prevent crop damage, disease transmission, and ensure effective pest management. This study presents a novel approach for aphid detection by utilizing hyperspectral imaging,... Read More about Detection of aphid infestation on faba bean (Vicia faba L.) by hyperspectral imaging and spectral information divergence methods.

Unraveling the lipid photooxidation reactions in salmon oil under different light wavelength conditions via omics approaches (2025)
Journal Article
Zhou, Z., Wang, B., Wang, L., Dong, M., Zhou, D., Huang, X., Fisk, I., & Qin, L. (2025). Unraveling the lipid photooxidation reactions in salmon oil under different light wavelength conditions via omics approaches. Food Chemistry, 488, Article 144867. https://doi.org/10.1016/j.foodchem.2025.144867

Light wavelengths can lead to differences in flavor and components of food by lipid photooxidation. However, the relevant molecular mechanisms are still unclear. This study explored the effects of light wavelengths (365 and 405 nm) on volatile and no... Read More about Unraveling the lipid photooxidation reactions in salmon oil under different light wavelength conditions via omics approaches.

Mathematical modelling of carbohydrate and protein metabolism in muscle (2025)
Journal Article
Alharbi, B. M., Williams, H. E., Parr, T., Brameld, J. M., Fallaize, C., & Wattis, J. A. (2025). Mathematical modelling of carbohydrate and protein metabolism in muscle. Mathematical Biosciences, 386, Article 109455. https://doi.org/10.1016/j.mbs.2025.109455

We propose a mathematical model based on coupled ordinary differential equations (ODEs) for metabolite concentrations with the aim of investigating how modifications to the rates affects outputs from a regulatory network. Our aim is to model the rela... Read More about Mathematical modelling of carbohydrate and protein metabolism in muscle.

Is There a Specific Role for Fungal Protein Within Food Based Dietary Guidelines? A Roundtable Discussion (2025)
Journal Article
Derbyshire, E. J., Brameld, J. M., Wall, B. T., Thomas, P., Arens, U., Forde, C. G., Hall, W., Glenn, A. J., Hill, T. R., & Paxman, J. (2025). Is There a Specific Role for Fungal Protein Within Food Based Dietary Guidelines? A Roundtable Discussion. Nutrition Bulletin, 1-15. https://doi.org/10.1111/nbu.70011

Expanding and aging populations, sustainability drivers and changing attitudes to the way we eat mean that there has been growing interest in non-animal derived protein food sources. Given this shift, there has been an uprise in consumer demand and c... Read More about Is There a Specific Role for Fungal Protein Within Food Based Dietary Guidelines? A Roundtable Discussion.

Evaluating the impact of simulated microgravity of a Random Positioning Machine on the stability of emulsions applying scaling analysis via dimensionless numbers (2025)
Preprint / Working Paper
Schmidt, S., Adebowale, M. N., Rebrov, E., Fisk, I., Yang, N., Saarela, M., & Hessel, V. (2025). Evaluating the impact of simulated microgravity of a Random Positioning Machine on the stability of emulsions applying scaling analysis via dimensionless numbers

Random Positioning Machines (RPM) are commonly used to simulate microgravity for plant growth and cell culturing experiments, but not properly in multi-phase flow studies, e.g., emulsions. The implications of fluid motion induced by RPM movement patt... Read More about Evaluating the impact of simulated microgravity of a Random Positioning Machine on the stability of emulsions applying scaling analysis via dimensionless numbers.

Screening of anti-inflammatory components in composite Houttuynia mixture using comprehensive two-dimensional ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry and network pharmacology (2025)
Journal Article
Lin, X., Zhou, L., Chen, L., Chen, Q., Jin, Z., Zhu, P., & Yang, N. (2025). Screening of anti-inflammatory components in composite Houttuynia mixture using comprehensive two-dimensional ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry and network pharmacology. Microchemical Journal, 213, Article 113660. https://doi.org/10.1016/j.microc.2025.113660

Houttuynia cordata Thunb. is a perennial herb with a distinct “fishy” flavour, commonly used in Asian cuisine and traditional medicine. To overcome the compound identification challenges in the composite formula of its mixture, a comprehensive two-di... Read More about Screening of anti-inflammatory components in composite Houttuynia mixture using comprehensive two-dimensional ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry and network pharmacology.

TMT-based quantitative proteomic assessment of Vicia sativa induced neurotoxicity by β-cyano-L-alanine and γ-glutamyl-β-cyano-L-alanine in SH-SY5Y cells (2025)
Preprint / Working Paper
Riley, S., Nguyen, V., Bhattacharjee, R., Ng, P. Q., Ritchie, T., Fisk, I., Gecz, J., Kumar, R., & Searle, I. R. (2025). TMT-based quantitative proteomic assessment of Vicia sativa induced neurotoxicity by β-cyano-L-alanine and γ-glutamyl-β-cyano-L-alanine in SH-SY5Y cells

β-Cyano-L-alanine (BCA) and γ-glutamyl-β-cyano-L-alanine (GBCA) are the primary antinutritional compounds present within the seeds of the high protein and drought tolerant orphan legume Vicia sativa. Evidence of neurotoxicity is limited to symptom an... Read More about TMT-based quantitative proteomic assessment of Vicia sativa induced neurotoxicity by β-cyano-L-alanine and γ-glutamyl-β-cyano-L-alanine in SH-SY5Y cells.

Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients With Brain Tumors: A Systematic Review (2025)
Journal Article
AlMutairi, H., Mccullough, F., Siddiqui, K., Ghemlas, I., AlHarbi, M., Grundy, R., & Dandapani, M. (2025). Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients With Brain Tumors: A Systematic Review. Journal of Nutrition and Metabolism, https://doi.org/10.1155/jnme/7935879

Background: Evidence suggests the positive effects of ketogenic diet (KD) on cancers by limiting glucose availability to cancer cells. This systematic review aimed to explore the safety, feasibility, and effectiveness of KD in children with brain tum... Read More about Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients With Brain Tumors: A Systematic Review.

Octopamine alters yellow mealworm body composition (2025)
Journal Article
Hill, V., Williams, L., Salter, A., Brameld, J., & Parr, T. (2025). Octopamine alters yellow mealworm body composition. Animal, 19(5), Article 101490. https://doi.org/10.1016/j.animal.2025.101490

There is the potential to increase the production yield within the emerging insect industry in order to produce high-quality, sustainable protein. In invertebrates, the monoamine, octopamine (OA), has a similar role to that of noradrenaline in mammal... Read More about Octopamine alters yellow mealworm body composition.

Food insecurity amongst universal credit claimants: the benefits and nutrition study (BEANS), a cross-sectional online study (2025)
Journal Article
Thomas, M., Rose, P., Coneyworth, L., Harvey, J., Goulding, J., Stone, J., Padley, M., O’Reilly, P., & Welham, S. (2025). Food insecurity amongst universal credit claimants: the benefits and nutrition study (BEANS), a cross-sectional online study. European Journal of Nutrition, 64, Article 115. https://doi.org/10.1007/s00394-025-03596-y

Purpose
Increasing food insecurity (FIS) in the UK presents a major challenge to public health. Universal Credit (UC) claimants are disproportionately impacted by FIS but research on socio-demographic factors and consequent nutritional security is... Read More about Food insecurity amongst universal credit claimants: the benefits and nutrition study (BEANS), a cross-sectional online study.

The anti-inflammatory effects of vitamin D on offspring brain development during pregnancy: critical review (2025)
Journal Article
Kozhevnikova, S. V., Elmes, M. J., Brameld, J. M., & Jethwa, P. H. (in press). The anti-inflammatory effects of vitamin D on offspring brain development during pregnancy: critical review. Academia, Nutrition and Dietetics, 2(1), Article 7573. https://doi.org/10.20935/acadnutr7573

Vitamin D (VD) plays a pivotal role in fetal brain development by regulating essential processes such as neuronal proliferation, differentiation, and apoptosis. Despite the critical role of VD in maternal and fetal health, studies have shown that alm... Read More about The anti-inflammatory effects of vitamin D on offspring brain development during pregnancy: critical review.

Enzymatic Synthesis of Functional PEGylated Adipate Copolymers (2025)
Journal Article
Axioti, E., Dixon, E. G., Jepras, T., Tin He, F., Hartman, P. J., Hopkins, B., Di Bari, V., Suksiriworapong, J., Cuzzucoli Crucitti, V., Galantini, L., Francolini, I., Cavanagh, R. J., & Taresco, V. (2025). Enzymatic Synthesis of Functional PEGylated Adipate Copolymers. ChemPlusChem, 90(5), Article e202400668. https://doi.org/10.1002/cplu.202400668

Many new active pharmaceutical ingredients (APIs) demonstrate high hydrophobicity and low water-solubility issues. In this regard, polymeric nanoparticles (NPs) have been extensively used as drug delivery carriers for the encapsulation of such APIs.... Read More about Enzymatic Synthesis of Functional PEGylated Adipate Copolymers.