IL-36? induces maturation of Th1-inducing human MDDC and synergises with IFN-? to induce high surface expression of CD14 and CD11c

Higgins, John; Mutamba, Shilla; Mahida, Yashwant R.; Barrow, Paul; Foster, Neil

doi:10.1016/j.humimm.2015.01.012

All Outputs (2)

Pathogenesis of Clostridium difficile infection and its potential role in inflammatory bowel disease (2015)
Journal Article

mild diarrhea to life-threatening colitis. Over the last 15 years, there has been a marked increase in the incidence of C. difficile infection, which predominantly affects elderly patients on antibiotics. More recently, there has been significant int... Read More about Pathogenesis of Clostridium difficile infection and its potential role in inflammatory bowel disease.

IL-36? induces maturation of Th1-inducing human MDDC and synergises with IFN-? to induce high surface expression of CD14 and CD11c (2015)
Journal Article

We show that IL-36? induced maturation of human MDDCs and stimulated differentiation of IFN-? producing (Type 1) CD3+ lymphocytes but was not as effective as IL-36? in doing so. For the first time, we also show that IL-36? induced expression of CD14... Read More about IL-36? induces maturation of Th1-inducing human MDDC and synergises with IFN-? to induce high surface expression of CD14 and CD11c.