Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD)

Swain, S.; Sarmanova, A.; Mallen, C.; Kuo, C. F.; Coupland, C.; Doherty, M.; Zhang, W.

doi:10.1016/j.joca.2020.03.004

Prevalence of ultrasound-detected knee synovial abnormalities in a middle-aged and older general population—the Xiangya Osteoarthritis Study (2021)
Journal Article
Jiang, T., Yang, T., Zhang, W., Doherty, M., Zhang, Y., Wei, J., Sarmanova, A., Hall, M., Yang, Z., Li, J., Fernandes, G. S., Obotiba, A. D., Gohir, S. A., Courtney, P., Zeng, C., & Lei, G. (2021). Prevalence of ultrasound-detected knee synovial abnormalities in a middle-aged and older general population—the Xiangya Osteoarthritis Study. Arthritis Research and Therapy, 23(1), Article 156. https://doi.org/10.1186/s13075-021-02539-2

Background: There is paucity of data on the prevalence of ultrasound-detected synovial abnormalities in the general population, and the relationship between synovial changes and knee pain remains unclear. We examined the prevalence of synovial abnorm... Read More about Prevalence of ultrasound-detected knee synovial abnormalities in a middle-aged and older general population—the Xiangya Osteoarthritis Study.

Associations of peripheral and central pain mechanisms with voluntary muscle strength in people with knee pain (2021)
Journal Article
Yue, B., McWilliams, D., Smith, S., Stocks, J., Sarmanova, A., Fernandes, G., Swaithes, L., Frowd, N., Doherty, M., Zhang, W., Valdes, A., Hall, M., & Walsh, D. (2021). Associations of peripheral and central pain mechanisms with voluntary muscle strength in people with knee pain. Osteoarthritis and Cartilage, 29(Suppl 1), S366-S367. https://doi.org/10.1016/j.joca.2021.02.475

Synovitis and bone marrow lesions associate with symptoms and radiographic progression in hand osteoarthritis: a systematic review and meta-analysis of observational studies (2021)
Journal Article
Obotiba, A. D., Swain, S., Kaur, J., Yaseen, K., Doherty, M., Zhang, W., & Abhishek, A. (2021). Synovitis and bone marrow lesions associate with symptoms and radiographic progression in hand osteoarthritis: a systematic review and meta-analysis of observational studies. Osteoarthritis and Cartilage, 29(7), 946-955. https://doi.org/10.1016/j.joca.2021.03.018

Aims: To systematically review observational studies for the association between features detected on ultrasound (US) and magnetic resonance imaging (MRI) and, symptoms, signs and radiographic progression of hand osteoarthritis (OA). Methods: Medline... Read More about Synovitis and bone marrow lesions associate with symptoms and radiographic progression in hand osteoarthritis: a systematic review and meta-analysis of observational studies.

Association Between Gut Microbiota and Symptomatic Hand Osteoarthritis: Data From the Xiangya Osteoarthritis Study (2021)
Journal Article
Wei, J., Zhang, C., Zhang, Y., Zhang, W., Doherty, M., Yang, T., Zhai, G., Obotiba, A. D., Lyu, H., Zeng, C., & Lei, G. (2021). Association Between Gut Microbiota and Symptomatic Hand Osteoarthritis: Data From the Xiangya Osteoarthritis Study. Arthritis and Rheumatology, 73(9), 1656-1662. https://doi.org/10.1002/art.41729

Objective: Systemic inflammatory factors have been implicated in symptomatic hand osteoarthritis (OA). Gut microbiome dysbiosis promotes systemic inflammation. The aim of this study was to examine the association between the gut microbiome and the pr... Read More about Association Between Gut Microbiota and Symptomatic Hand Osteoarthritis: Data From the Xiangya Osteoarthritis Study.

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Zhang, W., Doherty, M., Taal, M. W., Aithal, G. P., & Abhishek, A. (2021). What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?. Rheumatology, 60(12), 5785-5794. https://doi.org/10.1093/rheumatology/keab254

Objectives: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.

β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study (2021)
Journal Article
Nakafero, G., Grainge, M. J., Valdes, A. M., Townsend, N., D. Mallen, C., Zhang, W., Doherty, M., Mamas, M., & Abhishek, A. (2021). β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study. Rheumatology, 60(12), 5686-5696. https://doi.org/10.1093/rheumatology/keab234

Objectives: To examine the association between β-blocker prescription and first primary-care consultation for knee OA, hip OA, knee pain and hip pain. Methods: Data source: Clinical Practice Research Datalink. Participants aged ≥40 years in receipt o... Read More about β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study.

Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting (2021)
Journal Article
Swain, S., Coupland, C., Mallen, C., Kuo, C. F., Sarmanova, A., Bierma-Zeinstra, S. M., Englund, M., Prieto-Alhambra, D., Doherty, M., & Zhang, W. (2021). Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting. Rheumatology, 60(9), 4327-4339. https://doi.org/10.1093/rheumatology/keab067

OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK.

METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched n... Read More about Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting.

Efficacy and safety of multiple intra-articular corticosteroid injections for osteoarthritis—a systematic review and meta-analysis of randomized controlled trials and observational studies (2021)
Journal Article
Ayub, S., Kaur, J., Espahbodi, S., Hall, M., Doherty, M., & Zhang, W. (2021). Efficacy and safety of multiple intra-articular corticosteroid injections for osteoarthritis—a systematic review and meta-analysis of randomized controlled trials and observational studies. Rheumatology, 60(4), 1629–1639. https://doi.org/10.1093/rheumatology/keaa808

Objectives
To investigate the efficacy and safety of multiple intra-articular corticosteroid (IACS) injections for the treatment of OA.

Methods
We conducted electronic searches of several databases for randomized controlled trials (RCTs) and obs... Read More about Efficacy and safety of multiple intra-articular corticosteroid injections for osteoarthritis—a systematic review and meta-analysis of randomized controlled trials and observational studies.

Effects of bariatric surgery on serum uric acid in people with obesity with or without hyperuricaemia and gout: a retrospective analysis (2021)
Journal Article
Lu, J., Bai, Z., Chen, Y., Li, Y., Tang, M., Wang, N., Zhu, X., Dai, H., & Zhang, W. (2021). Effects of bariatric surgery on serum uric acid in people with obesity with or without hyperuricaemia and gout: a retrospective analysis. Rheumatology, 60(8), 3628-3634. https://doi.org/10.1093/rheumatology/keaa822

Objectives: Weight reduction may reduce serum uric acid (SUA). This study aimed to examine the changes of SUA before and after bariatric surgery in patients with obesity with or without hyperuricaemia and gout. Methods: This is a retrospective analys... Read More about Effects of bariatric surgery on serum uric acid in people with obesity with or without hyperuricaemia and gout: a retrospective analysis.

Constitutional morphological features and risk of hip osteoarthritis: a case–control study using standard radiographs (2020)
Journal Article
Abdulrahim, H., Jiao, Q., Swain, S., Sehat, K., Sarmanova, A., Muir, K., Zhang, W., & Doherty, M. (2021). Constitutional morphological features and risk of hip osteoarthritis: a case–control study using standard radiographs. Annals of the Rheumatic Diseases, 80(4), 494-501. https://doi.org/10.1136/annrheumdis-2020-218739

© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. Objectives: To evaluate the risk of association with hip osteoarthritis (OA) of 14 morphological features measured on standard antero-posteri... Read More about Constitutional morphological features and risk of hip osteoarthritis: a case–control study using standard radiographs.

Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials (2020)
Journal Article
Persson, M. S., Stocks, J., Sarmanova, A., Fernandes, G., Walsh, D. A., Doherty, M., & Zhang, W. (2021). Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials. Rheumatology, 60(5), 2231-2237. https://doi.org/10.1093/rheumatology/keaa561

OBJECTIVES: To determine individual responses to ibuprofen gel or capsaicin cream for painful, radiographic knee OA using a series of n-of-1 trials. METHODS: Twenty-two participants were allocated 5% ibuprofen gel (A) and 0.025% capsaicin cream (B) i... Read More about Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials.

Level of physical activity among middle-aged and older Chinese people: evidence from the China health and retirement longitudinal study (2020)
Journal Article
Li, X., Zhang, W., Zhang, W., Tao, K., Ni, W., Wang, K., Li, Z., Liu, Q., & Lin, J. (2020). Level of physical activity among middle-aged and older Chinese people: evidence from the China health and retirement longitudinal study. BMC Public Health, 20(1), Article 1682. https://doi.org/10.1186/s12889-020-09671-9

Background: With data from different regions accumulated, physical inactivity (PI) was found to be pandemic worldwide. Using China Health and Retirement Longitudinal Study (CHARLS), a nationwide longitudinal survey data, we aimed to delineate the pre... Read More about Level of physical activity among middle-aged and older Chinese people: evidence from the China health and retirement longitudinal study.

Initial analgesic prescriptions for osteoarthritis in the United Kingdom, 2000-2016 (2020)
Journal Article
Zeng, C., Zhang, W., Doherty, M., Persson, M. S., Mallen, C., Swain, S., Li, X., Wei, J., Lei, G., & Zhang, Y. (2021). Initial analgesic prescriptions for osteoarthritis in the United Kingdom, 2000-2016. Rheumatology, 60(1), 147-159. https://doi.org/10.1093/rheumatology/keaa244

Objectives: To examine trends in the initial prescription of commonly-prescribed analgesics and patient- as well as practice-level factors related to their selection in incident OA. Methods: Patients consulting with incident clinical OA between 2000-... Read More about Initial analgesic prescriptions for osteoarthritis in the United Kingdom, 2000-2016.

Corrigendum to: Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study (2020)
Journal Article
Sarmanova, A., Doherty, M., Kuo, C., Wei, J., Abhishek, A., Mallen, C., Zeng, C., Wang, Y., Lei, G., & Zhang, W. (2020). Corrigendum to: Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study. Rheumatology, 59(10), 3120-3120. https://doi.org/10.1093/rheumatology/keaa223

Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies (2020)
Journal Article
Swain, S., Sarmanova, A., Coupland, C., Doherty, M., & Zhang, W. (2020). Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies. Arthritis Care and Research, 72(7), 991-1000. https://doi.org/10.1002/acr.24008

Objectives

Osteoarthritis (OA) is a common chronic condition in older people but its association with other chronic conditions is largely unknown. This study aimed to systematically review the literature on comorbidities in people with OA compared... Read More about Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies.

Pain distant from the index site and sensitization in people with knee pain and low back pain (2020)
Presentation / Conference Contribution
Akin-Akinyosoye, K., Georgopoulos, V., Frowd, N., Swaithes, L., Stocks, J., Fernandes, G. S., Valdes, A., McWilliams, D., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. (2020, April). Pain distant from the index site and sensitization in people with knee pain and low back pain. Presented at OARSI 2020 World Congress, Vienna, Austria

Mediators of the predictive relationship between a self-report measure of central mechanisms and future knee pain outcomes in the knee pain in the community (KPIC) cohort (2020)
Presentation / Conference Contribution
Matthews, R., Akin-Akinyosoye, K., Frowd, N., Swaithes, L., Stocks, J., Sarmanova, A., Fernandes, G. S., Valdes, A., McWilliams, D. F., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. A. (2020, April). Mediators of the predictive relationship between a self-report measure of central mechanisms and future knee pain outcomes in the knee pain in the community (KPIC) cohort. Presented at OARSI 2020 World Congress, Vienna, Austria

Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis (2020)
Journal Article
Jin, X., Antony, B., Wang, X., Persson, M. S., McAlindon, T., Arden, N. K., Arden, N. K., Srivastava, S., Srivastava, R., Van Middelkoop, M., Bierma-Zeinstra, S. M., Bierma-Zeinstra, S. M., Zhang, W., Cicuttini, F., & Ding, C. (2020). Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis. BMJ Open, 10(4), Article e035302. https://doi.org/10.1136/bmjopen-2019-035302

Introduction: Observational data suggest that vitamin D deficiency is associated with the onset and progression of knee osteoarthritis (OA). However, randomised controlled trials (RCTs) to date investigating the efficacy of vitamin D supplementation... Read More about Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis.

Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials (2020)
Journal Article
Persson, M. S., Stocks, J., Varadi, G., Hashempur, M. H., van Middelkoop, M., Bierma-Zeinstra, S., Walsh, D. A., Doherty, M., & Zhang, W. (2020). Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials. Rheumatology, 59(9), 2207-2216. https://doi.org/10.1093/rheumatology/keaa113

© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology.

OBJECTIVES: To identify predictors of the specific (difference between treatment and placebo) and overall (change from baseline in treat... Read More about Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials.

Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD) (2020)
Journal Article
Swain, S., Sarmanova, A., Mallen, C., Kuo, C. F., Coupland, C., Doherty, M., & Zhang, W. (2020). Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD). Osteoarthritis and Cartilage, 28(6), 792-801. https://doi.org/10.1016/j.joca.2020.03.004

© 2020 The Authors Objective: This study aimed to explore the incidence and prevalence of OA in the UK in 2017 and their trends from 1997 to 2017 using a large nationally representative primary care database. Design: The UK Clinical Practice Research... Read More about Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD).

All Outputs (155)