Effects of bariatric surgery on serum uric acid in people with obesity with or without hyperuricaemia and gout: a retrospective analysis

Lu, Jine; Bai, Zhiyao; Chen, Yunqing; Li, Yingxu; Tang, Min; Wang, Ning; Zhu, Xingcheng; Dai, Hongbin; Zhang, Weiya

Abstract

Objectives: Weight reduction may reduce serum uric acid (SUA). This study aimed to examine the changes of SUA before and after bariatric surgery in patients with obesity with or without hyperuricaemia and gout. Methods: This is a retrospective analysis of 147 routinely collected data on hospital patients with obesity who underwent bariatric surgery. The body weight and SUA were measured at baseline and after surgery at 1-7 days, 1, 3, 6 and 12 months. Results: The mean (95% CI) weight reduction of 147 patients was 30.7 (28.7, 32.7) kg 1 year after surgery (P < 0.001). SUA decreased rapidly from 419.0 (400.1, 437.8) μmol/l at baseline to 308.4 (289.6, 327.2) μmol/l at 1-7 days, flared up to 444.8 (423.9, 465.6) μmol/l at 1 month, then decreased again to 383.8 (361.5, 406.1) μmol/l at 3 months, 348.9 (326.3, 371.5) μmol/l at 6 months and 327.9 (305.3, 350.5) μmol/l at 12 months (P < 0.001). Similar trends but more rapid reductions were observed in 55 hyperuricaemia patients and 25 gout patients. All 25 gout patients had an elevated SUA above the therapeutic target (≥360μmmol/l) at baseline, but in 10 patients it was reduced below this target at 12 months. The mean reduction (95% CI) of SUA in all patients and gout patients was 84.3 (63.1-105.4) and 163.6 (103.9, 223.3) μmmol/l, respectively. Conclusion: Bariatric surgery significantly reduces body weight and SUA for obese patients with hyperuricaemia and gout. Gout may be considered as an indicator for this surgical treatment in people with severe obesity.

• Journal Article Type: Article
• Acceptance Date: Nov 4, 2020
• Online Publication Date: Jan 4, 2021
• Publication Date: Aug 1, 2021
• Deposit Date: Jan 4, 2024
• Journal: Rheumatology
• Print ISSN: 1462-0324
• Electronic ISSN: 1462-0332
• Publisher: Oxford University Press (OUP)
• Peer Reviewed: Peer Reviewed
• Volume: 60
• Issue: 8
• Pages: 3628-3634
• DOI: https://doi.org/10.1093/rheumatology/keaa822
• Keywords: obesity, hyperuricemia, gout, bariatric surgery, SUA
• Public URL: https://nottingham-repository.worktribe.com/output/25394483
• Publisher URL: https://academic.oup.com/rheumatology/article/60/8/3628/6062103